Search for partners of a new mammalian selenium-containing protein V (SelV) and expression of its mRNA during ontogenesis and spermatogenesis
Selenium is a biologically active trace element. Being a part of several proteins, it is associated with the activity of many organs, tissues, and systems of the organism. To date, there are 25 mammalian selenoproteins, one of which is SelV (Selenoprotein V). Since this protein has a thioredoxin-lik...
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| Veröffentlicht in: | Molecular biology (New York) 2012-04, Vol.46 (2), p.250-257 |
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| creator | Varlamova, E. G. Novoselov, V. I. |
| description | Selenium is a biologically active trace element. Being a part of several proteins, it is associated with the activity of many organs, tissues, and systems of the organism. To date, there are 25 mammalian selenoproteins, one of which is SelV (Selenoprotein V). Since this protein has a thioredoxin-like folding and a conserved motif CXXU (where C is cystein and U is selenocystein) in its catalytic center, it belongs to the redox proteins family participating in redox reactions. In this paper the redox protein SelV was shown to be able to interact with O-linked N-acetylglucosamine transferase (OGT) and proteins belonging to the ASB family (Asb-17 and Asb-9). The specificity of SelV interactions with OGT and Asb-9, but not with Asb-17, is confirmed by the co-immunoprecipitation method. In addition, expression of SelV mRNA in the later stages of spermatogenesis, as well as in puberty, and the reproductive periods of rats, is shown. |
| doi_str_mv | 10.1134/S0026893312010244 |
| format | Article |
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G. ; Novoselov, V. I.</creator><creatorcontrib>Varlamova, E. G. ; Novoselov, V. I.</creatorcontrib><description>Selenium is a biologically active trace element. Being a part of several proteins, it is associated with the activity of many organs, tissues, and systems of the organism. To date, there are 25 mammalian selenoproteins, one of which is SelV (Selenoprotein V). Since this protein has a thioredoxin-like folding and a conserved motif CXXU (where C is cystein and U is selenocystein) in its catalytic center, it belongs to the redox proteins family participating in redox reactions. In this paper the redox protein SelV was shown to be able to interact with O-linked N-acetylglucosamine transferase (OGT) and proteins belonging to the ASB family (Asb-17 and Asb-9). The specificity of SelV interactions with OGT and Asb-9, but not with Asb-17, is confirmed by the co-immunoprecipitation method. 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| subjects | Biochemistry Biomedical and Life Sciences Conserved sequence Gene expression Human Genetics Life Sciences Molecular biology Molecular Biology of the Cell mRNA N-Acetylglucosamine protein families Protein folding Proteins Puberty Ribonucleic acid RNA Selenium selenoproteins Spermatogenesis Trace elements |
| title | Search for partners of a new mammalian selenium-containing protein V (SelV) and expression of its mRNA during ontogenesis and spermatogenesis |
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