A toxicological evaluation of inhaled solid lipid nanoparticles used as a potential drug delivery system for the lung

Inhalation is a non-invasive approach for both local and systemic drug delivery. This study aimed to define the therapeutic window for solid lipid nanoparticles (SLNs) as a drug delivery system by inhalation from a toxicological point of view. To estimate the toxic dose of SLNs in vitro, A549 cells...

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Veröffentlicht in:	European journal of pharmaceutics and biopharmaceutics 2010-06, Vol.75 (2), p.107-116
Hauptverfasser:	Nassimi, M., Schleh, C., Lauenstein, H.D., Hussein, R., Hoymann, H.G., Koch, W., Pohlmann, G., Krug, N., Sewald, K., Rittinghausen, S., Braun, A., Müller-Goymann, C.
Format:	Artikel
Sprache:	eng
Schlagworte:	A549 Administration, Inhalation Animals BALB/c mice Biological and medical sciences Bronchoalveolar Lavage Fluid Cell Line, Tumor Cytotoxicity Dose-Response Relationship, Drug Drug delivery Drug Delivery Systems Female General pharmacology Humans Inflammation Inflammation - chemically induced Inflammation - physiopathology Lipids - administration & dosage Lipids - chemistry Lipids - toxicity Lung - drug effects Lung - metabolism Medical sciences Mice Mice, Inbred BALB C Microscopy, Confocal Nanoparticles - toxicity Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Precision-cut lung slices Pro-inflammatory cytokines Solid lipid nanoparticle Time Factors Toxicity Tests
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