Size and phospholipid coating of lipid droplets in the diet of young mice modify body fat accumulation in adulthood
Background: In addition to contemporary lifestyle factors that contribute to the increased obesity prevalence worldwide, early nutrition is associated with sustained effects on later life obesity. We hypothesized that physical properties of dietary lipids contribute to this nutritional programming....
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| Veröffentlicht in: | Pediatric research 2012-10, Vol.72 (4), p.362-369 |
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| container_title | Pediatric research |
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| creator | Oosting, Annemarie Kegler, Diane Wopereis, Harm J. Teller, Inga C. van de Heijning, Bert J.M. Verkade, Henkjan J. van der Beek, Eline M. |
| description | Background:
In addition to contemporary lifestyle factors that contribute to the increased obesity prevalence worldwide, early nutrition is associated with sustained effects on later life obesity. We hypothesized that physical properties of dietary lipids contribute to this nutritional programming. We developed a concept infant formula (IMF) with large, phospholipid-coated lipid droplets (Nuturis; Danone Research, Paris, France) and investigated its programming effect on metabolic phenotype later in life.
Methods:
Male C57Bl/6j mice were fed a control formula (Control IMF) or Nuturis (Concept IMF) diet between postnatal day (PN)16 and PN42. All mice were subsequently fed a Western-style diet (WSD) until PN126. Body composition was monitored repeatedly by dual-energy X-ray absorptiometry between PN42 and PN126.
Results:
Concept IMF slightly increased lean body mass as compared with Control IMF at PN42 but did not affect fat mass. Upon 84 d of WSD feeding, the Concept IMF group showed reduced fat accumulation as compared with Control IMF. In addition, fasting plasma leptin, resistin, glucose, and lipids were significantly lower in the Concept IMF group.
Conclusion:
Large phospholipid-coated lipid droplets in young mice reduced fat accumulation and improved metabolic profile in adulthood. These data emphasize that physical properties of early dietary lipids contribute to metabolic programming. |
| doi_str_mv | 10.1038/pr.2012.101 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1082408843</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1082408843</sourcerecordid><originalsourceid>FETCH-LOGICAL-c393t-15206c27801d4b182e6e17621d52c777d43559a011e3b2e279935150343e49ec3</originalsourceid><addsrcrecordid>eNpt0E1P3DAQBmCrKioL9NR75QsSEg2MvxL7iFC_JKQeCufIa09YoyQOdnJYfj1e7RYuPVjWeB7PSC8hXxhcMRD6ekpXHBgvBftAVkwJqEDK5iNZAQhWCWP0MTnJ-QmASaXlJ3LMuVYgwaxI_htekNrR02kTczl9mIKnLto5jI80dnT_4FOcepwzDSOdN0h9wHnX3calsCE4pEP0odvSdfRb2tmZWueWYenLoDjuvlm_9PMmRn9GjjrbZ_x8uE_Jw4_v97e_qrs_P3_f3txVThgxV0xxqB1vNDAv10xzrJE1NWdecdc0jZdCKWOBMRRrjrwxRiimQEiB0qATp-RiP3dK8XnBPLdDyA773o4Yl9wy0FyC1lIUermnLsWcE3btlMJg07agdpdyqdtdyqVgRX89DF7WA_o3-y_WAs4PwGZn-y7Z0YX87mop68bw4r7tXS6t8RFT-xSXNJZQ_rv3FXwBkmA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1082408843</pqid></control><display><type>article</type><title>Size and phospholipid coating of lipid droplets in the diet of young mice modify body fat accumulation in adulthood</title><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Alma/SFX Local Collection</source><creator>Oosting, Annemarie ; Kegler, Diane ; Wopereis, Harm J. ; Teller, Inga C. ; van de Heijning, Bert J.M. ; Verkade, Henkjan J. ; van der Beek, Eline M.</creator><creatorcontrib>Oosting, Annemarie ; Kegler, Diane ; Wopereis, Harm J. ; Teller, Inga C. ; van de Heijning, Bert J.M. ; Verkade, Henkjan J. ; van der Beek, Eline M.</creatorcontrib><description>Background:
In addition to contemporary lifestyle factors that contribute to the increased obesity prevalence worldwide, early nutrition is associated with sustained effects on later life obesity. We hypothesized that physical properties of dietary lipids contribute to this nutritional programming. We developed a concept infant formula (IMF) with large, phospholipid-coated lipid droplets (Nuturis; Danone Research, Paris, France) and investigated its programming effect on metabolic phenotype later in life.
Methods:
Male C57Bl/6j mice were fed a control formula (Control IMF) or Nuturis (Concept IMF) diet between postnatal day (PN)16 and PN42. All mice were subsequently fed a Western-style diet (WSD) until PN126. Body composition was monitored repeatedly by dual-energy X-ray absorptiometry between PN42 and PN126.
Results:
Concept IMF slightly increased lean body mass as compared with Control IMF at PN42 but did not affect fat mass. Upon 84 d of WSD feeding, the Concept IMF group showed reduced fat accumulation as compared with Control IMF. In addition, fasting plasma leptin, resistin, glucose, and lipids were significantly lower in the Concept IMF group.
Conclusion:
Large phospholipid-coated lipid droplets in young mice reduced fat accumulation and improved metabolic profile in adulthood. These data emphasize that physical properties of early dietary lipids contribute to metabolic programming.</description><identifier>ISSN: 0031-3998</identifier><identifier>EISSN: 1530-0447</identifier><identifier>DOI: 10.1038/pr.2012.101</identifier><identifier>PMID: 22850409</identifier><identifier>CODEN: PEREBL</identifier><language>eng</language><publisher>New York: Nature Publishing Group US</publisher><subject>692/308/575 ; 692/699/2743/393 ; 692/700/1720 ; Absorptiometry, Photon ; Adiposity ; Aging - metabolism ; Animal Nutritional Physiological Phenomena ; Animals ; Biological and medical sciences ; Biomarkers - blood ; Blood Glucose - metabolism ; Dietary Fats - blood ; Dietary Fats - metabolism ; Eating ; Fasting - blood ; General aspects ; Humans ; Infant ; Infant Formula - metabolism ; Leptin - blood ; Male ; Medical sciences ; Medicine ; Medicine & Public Health ; Metabolic diseases ; Mice ; Mice, Inbred C57BL ; Nutritional Status ; Particle Size ; Pediatric Surgery ; Pediatrics ; Phospholipids - blood ; Phospholipids - metabolism ; Resistin - blood ; translational-investigation ; Weight Gain</subject><ispartof>Pediatric research, 2012-10, Vol.72 (4), p.362-369</ispartof><rights>International Pediatric Research Foundation, Inc. 2012</rights><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c393t-15206c27801d4b182e6e17621d52c777d43559a011e3b2e279935150343e49ec3</citedby><cites>FETCH-LOGICAL-c393t-15206c27801d4b182e6e17621d52c777d43559a011e3b2e279935150343e49ec3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=26446792$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22850409$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Oosting, Annemarie</creatorcontrib><creatorcontrib>Kegler, Diane</creatorcontrib><creatorcontrib>Wopereis, Harm J.</creatorcontrib><creatorcontrib>Teller, Inga C.</creatorcontrib><creatorcontrib>van de Heijning, Bert J.M.</creatorcontrib><creatorcontrib>Verkade, Henkjan J.</creatorcontrib><creatorcontrib>van der Beek, Eline M.</creatorcontrib><title>Size and phospholipid coating of lipid droplets in the diet of young mice modify body fat accumulation in adulthood</title><title>Pediatric research</title><addtitle>Pediatr Res</addtitle><addtitle>Pediatr Res</addtitle><description>Background:
In addition to contemporary lifestyle factors that contribute to the increased obesity prevalence worldwide, early nutrition is associated with sustained effects on later life obesity. We hypothesized that physical properties of dietary lipids contribute to this nutritional programming. We developed a concept infant formula (IMF) with large, phospholipid-coated lipid droplets (Nuturis; Danone Research, Paris, France) and investigated its programming effect on metabolic phenotype later in life.
Methods:
Male C57Bl/6j mice were fed a control formula (Control IMF) or Nuturis (Concept IMF) diet between postnatal day (PN)16 and PN42. All mice were subsequently fed a Western-style diet (WSD) until PN126. Body composition was monitored repeatedly by dual-energy X-ray absorptiometry between PN42 and PN126.
Results:
Concept IMF slightly increased lean body mass as compared with Control IMF at PN42 but did not affect fat mass. Upon 84 d of WSD feeding, the Concept IMF group showed reduced fat accumulation as compared with Control IMF. In addition, fasting plasma leptin, resistin, glucose, and lipids were significantly lower in the Concept IMF group.
Conclusion:
Large phospholipid-coated lipid droplets in young mice reduced fat accumulation and improved metabolic profile in adulthood. These data emphasize that physical properties of early dietary lipids contribute to metabolic programming.</description><subject>692/308/575</subject><subject>692/699/2743/393</subject><subject>692/700/1720</subject><subject>Absorptiometry, Photon</subject><subject>Adiposity</subject><subject>Aging - metabolism</subject><subject>Animal Nutritional Physiological Phenomena</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Biomarkers - blood</subject><subject>Blood Glucose - metabolism</subject><subject>Dietary Fats - blood</subject><subject>Dietary Fats - metabolism</subject><subject>Eating</subject><subject>Fasting - blood</subject><subject>General aspects</subject><subject>Humans</subject><subject>Infant</subject><subject>Infant Formula - metabolism</subject><subject>Leptin - blood</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Metabolic diseases</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Nutritional Status</subject><subject>Particle Size</subject><subject>Pediatric Surgery</subject><subject>Pediatrics</subject><subject>Phospholipids - blood</subject><subject>Phospholipids - metabolism</subject><subject>Resistin - blood</subject><subject>translational-investigation</subject><subject>Weight Gain</subject><issn>0031-3998</issn><issn>1530-0447</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpt0E1P3DAQBmCrKioL9NR75QsSEg2MvxL7iFC_JKQeCufIa09YoyQOdnJYfj1e7RYuPVjWeB7PSC8hXxhcMRD6ekpXHBgvBftAVkwJqEDK5iNZAQhWCWP0MTnJ-QmASaXlJ3LMuVYgwaxI_htekNrR02kTczl9mIKnLto5jI80dnT_4FOcepwzDSOdN0h9wHnX3calsCE4pEP0odvSdfRb2tmZWueWYenLoDjuvlm_9PMmRn9GjjrbZ_x8uE_Jw4_v97e_qrs_P3_f3txVThgxV0xxqB1vNDAv10xzrJE1NWdecdc0jZdCKWOBMRRrjrwxRiimQEiB0qATp-RiP3dK8XnBPLdDyA773o4Yl9wy0FyC1lIUermnLsWcE3btlMJg07agdpdyqdtdyqVgRX89DF7WA_o3-y_WAs4PwGZn-y7Z0YX87mop68bw4r7tXS6t8RFT-xSXNJZQ_rv3FXwBkmA</recordid><startdate>20121001</startdate><enddate>20121001</enddate><creator>Oosting, Annemarie</creator><creator>Kegler, Diane</creator><creator>Wopereis, Harm J.</creator><creator>Teller, Inga C.</creator><creator>van de Heijning, Bert J.M.</creator><creator>Verkade, Henkjan J.</creator><creator>van der Beek, Eline M.</creator><general>Nature Publishing Group US</general><general>Lippincott Williams & Wilkins</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20121001</creationdate><title>Size and phospholipid coating of lipid droplets in the diet of young mice modify body fat accumulation in adulthood</title><author>Oosting, Annemarie ; Kegler, Diane ; Wopereis, Harm J. ; Teller, Inga C. ; van de Heijning, Bert J.M. ; Verkade, Henkjan J. ; van der Beek, Eline M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c393t-15206c27801d4b182e6e17621d52c777d43559a011e3b2e279935150343e49ec3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>692/308/575</topic><topic>692/699/2743/393</topic><topic>692/700/1720</topic><topic>Absorptiometry, Photon</topic><topic>Adiposity</topic><topic>Aging - metabolism</topic><topic>Animal Nutritional Physiological Phenomena</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Biomarkers - blood</topic><topic>Blood Glucose - metabolism</topic><topic>Dietary Fats - blood</topic><topic>Dietary Fats - metabolism</topic><topic>Eating</topic><topic>Fasting - blood</topic><topic>General aspects</topic><topic>Humans</topic><topic>Infant</topic><topic>Infant Formula - metabolism</topic><topic>Leptin - blood</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Metabolic diseases</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>Nutritional Status</topic><topic>Particle Size</topic><topic>Pediatric Surgery</topic><topic>Pediatrics</topic><topic>Phospholipids - blood</topic><topic>Phospholipids - metabolism</topic><topic>Resistin - blood</topic><topic>translational-investigation</topic><topic>Weight Gain</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Oosting, Annemarie</creatorcontrib><creatorcontrib>Kegler, Diane</creatorcontrib><creatorcontrib>Wopereis, Harm J.</creatorcontrib><creatorcontrib>Teller, Inga C.</creatorcontrib><creatorcontrib>van de Heijning, Bert J.M.</creatorcontrib><creatorcontrib>Verkade, Henkjan J.</creatorcontrib><creatorcontrib>van der Beek, Eline M.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Pediatric research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Oosting, Annemarie</au><au>Kegler, Diane</au><au>Wopereis, Harm J.</au><au>Teller, Inga C.</au><au>van de Heijning, Bert J.M.</au><au>Verkade, Henkjan J.</au><au>van der Beek, Eline M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Size and phospholipid coating of lipid droplets in the diet of young mice modify body fat accumulation in adulthood</atitle><jtitle>Pediatric research</jtitle><stitle>Pediatr Res</stitle><addtitle>Pediatr Res</addtitle><date>2012-10-01</date><risdate>2012</risdate><volume>72</volume><issue>4</issue><spage>362</spage><epage>369</epage><pages>362-369</pages><issn>0031-3998</issn><eissn>1530-0447</eissn><coden>PEREBL</coden><abstract>Background:
In addition to contemporary lifestyle factors that contribute to the increased obesity prevalence worldwide, early nutrition is associated with sustained effects on later life obesity. We hypothesized that physical properties of dietary lipids contribute to this nutritional programming. We developed a concept infant formula (IMF) with large, phospholipid-coated lipid droplets (Nuturis; Danone Research, Paris, France) and investigated its programming effect on metabolic phenotype later in life.
Methods:
Male C57Bl/6j mice were fed a control formula (Control IMF) or Nuturis (Concept IMF) diet between postnatal day (PN)16 and PN42. All mice were subsequently fed a Western-style diet (WSD) until PN126. Body composition was monitored repeatedly by dual-energy X-ray absorptiometry between PN42 and PN126.
Results:
Concept IMF slightly increased lean body mass as compared with Control IMF at PN42 but did not affect fat mass. Upon 84 d of WSD feeding, the Concept IMF group showed reduced fat accumulation as compared with Control IMF. In addition, fasting plasma leptin, resistin, glucose, and lipids were significantly lower in the Concept IMF group.
Conclusion:
Large phospholipid-coated lipid droplets in young mice reduced fat accumulation and improved metabolic profile in adulthood. These data emphasize that physical properties of early dietary lipids contribute to metabolic programming.</abstract><cop>New York</cop><pub>Nature Publishing Group US</pub><pmid>22850409</pmid><doi>10.1038/pr.2012.101</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Pediatric research, 2012-10, Vol.72 (4), p.362-369 |
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| subjects | 692/308/575 692/699/2743/393 692/700/1720 Absorptiometry, Photon Adiposity Aging - metabolism Animal Nutritional Physiological Phenomena Animals Biological and medical sciences Biomarkers - blood Blood Glucose - metabolism Dietary Fats - blood Dietary Fats - metabolism Eating Fasting - blood General aspects Humans Infant Infant Formula - metabolism Leptin - blood Male Medical sciences Medicine Medicine & Public Health Metabolic diseases Mice Mice, Inbred C57BL Nutritional Status Particle Size Pediatric Surgery Pediatrics Phospholipids - blood Phospholipids - metabolism Resistin - blood translational-investigation Weight Gain |
| title | Size and phospholipid coating of lipid droplets in the diet of young mice modify body fat accumulation in adulthood |
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