Simultaneous determination of atorvastatin and niacin in human plasma by LC-MS/MS and its application to a human pharmacokinetic study

ABSTRACT A rapid, simple, sensitive and selective LC‐MS/MS method has been developed and validated for quantification of the atorvastatin (AT) and niacin (NA) in 250 μL human plasma. The analytical procedure involves a liquid–liquid extraction method using nevirapine as an internal standard (IS). Th...

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Veröffentlicht in:	Biomedical chromatography 2012-11, Vol.26 (11), p.1436-1443
Hauptverfasser:	Ravi, Vasu Babu, Mullangi, Ramesh, Inamadugu, Jaswanth Kumar, Pilli, Nageswara Rao, Gajula, Ramakrishna, Ponneri, Venkateswarlu
Format:	Artikel
Sprache:	eng
Schlagworte:	atorvastatin Atorvastatin Calcium Chromatography, High Pressure Liquid - methods Drug Stability Heptanoic Acids - blood Heptanoic Acids - chemistry Heptanoic Acids - pharmacokinetics human plasma Humans LC-MS/MS Linear Models Liquid-Liquid Extraction Male method validation Nevirapine - blood niacin Niacin - blood Niacin - chemistry Niacin - pharmacokinetics pharmacokinetics Pyrroles - blood Pyrroles - chemistry Pyrroles - pharmacokinetics Reproducibility of Results Sensitivity and Specificity Tandem Mass Spectrometry - methods
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