Amygdala Response to Preattentive Masked Fear in Children With Conduct Problems: The Role of Callous-Unemotional Traits
ObjectiveIn children with conduct problems, high levels of callous-unemotional traits are associated with amygdala hypoactivity to consciously perceived fear, while low levels of callous-unemotional traits may be associated with amygdala hyperactivity. Behavioral data suggest that fear processing de...
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| Veröffentlicht in: | The American journal of psychiatry 2012-10, Vol.169 (10), p.1109-1116 |
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| container_title | The American journal of psychiatry |
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| creator | Viding, Essi Sebastian, Catherine L. Dadds, Mark R. Lockwood, Patricia L. Cecil, Charlotte A.M. De Brito, Stephane A. McCrory, Eamon J. |
| description | ObjectiveIn children with conduct problems, high levels of callous-unemotional traits are associated with amygdala hypoactivity to consciously perceived fear, while low levels of callous-unemotional traits may be associated with amygdala hyperactivity. Behavioral data suggest that fear processing deficits in children with high callous-unemotional traits may extend to stimuli presented below conscious awareness (preattentively). The authors investigated the neural basis of this effect. Amygdala involvement was predicted on the basis of its role in preattentive affective processing in healthy adults and its dysfunction in previous studies of conduct problems.MethodFunctional MRI was used to measure neural responses to fearful and calm faces presented preattentively (for 17 ms followed by backward masking) in boys with conduct problems and high callous-unemotional traits (N=15), conduct problems and low callous-unemotional traits (N=15), and typically developing comparison boys (N=16). Amygdala response to fearful and calm faces was predicted to differentiate groups, with the greatest response in boys with conduct problems and low callous-unemotional traits and the lowest in boys with conduct problems and high callous-unemotional traits.ResultsIn the right amygdala, a greater amygdala response was seen in boys with conduct problems and low callous-unemotional traits than in those with high callous-unemotional traits. The findings were not explained by symptom levels of conduct disorder, attention-deficit hyperactivity disorder, anxiety, or depression.ConclusionsThese data demonstrate differential amygdala activity to preattentively presented fear in children with conduct problems grouped by callous-unemotional traits, with high levels associated with lower amygdala reactivity. The study’s findings complement increasing evidence suggesting that callous-unemotional traits are an important specifier in the classification of children with conduct problems. |
| doi_str_mv | 10.1176/appi.ajp.2012.12020191 |
| format | Article |
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Behavioral data suggest that fear processing deficits in children with high callous-unemotional traits may extend to stimuli presented below conscious awareness (preattentively). The authors investigated the neural basis of this effect. Amygdala involvement was predicted on the basis of its role in preattentive affective processing in healthy adults and its dysfunction in previous studies of conduct problems.MethodFunctional MRI was used to measure neural responses to fearful and calm faces presented preattentively (for 17 ms followed by backward masking) in boys with conduct problems and high callous-unemotional traits (N=15), conduct problems and low callous-unemotional traits (N=15), and typically developing comparison boys (N=16). Amygdala response to fearful and calm faces was predicted to differentiate groups, with the greatest response in boys with conduct problems and low callous-unemotional traits and the lowest in boys with conduct problems and high callous-unemotional traits.ResultsIn the right amygdala, a greater amygdala response was seen in boys with conduct problems and low callous-unemotional traits than in those with high callous-unemotional traits. The findings were not explained by symptom levels of conduct disorder, attention-deficit hyperactivity disorder, anxiety, or depression.ConclusionsThese data demonstrate differential amygdala activity to preattentively presented fear in children with conduct problems grouped by callous-unemotional traits, with high levels associated with lower amygdala reactivity. The study’s findings complement increasing evidence suggesting that callous-unemotional traits are an important specifier in the classification of children with conduct problems.</description><identifier>ISSN: 0002-953X</identifier><identifier>EISSN: 1535-7228</identifier><identifier>DOI: 10.1176/appi.ajp.2012.12020191</identifier><identifier>PMID: 23032389</identifier><identifier>CODEN: AJPSAO</identifier><language>eng</language><publisher>Arlington, VA: American Psychiatric Association</publisher><subject>Adolescent ; Amygdala - physiopathology ; Attention - physiology ; Behavior disorders ; Biological and medical sciences ; Child ; Child & adolescent psychiatry ; Conduct Disorder - physiopathology ; Conduct Disorder - psychology ; Emotions - physiology ; Empathy ; Facial Expression ; Fear & phobias ; Fear - physiology ; Functional Neuroimaging ; Humans ; Magnetic Resonance Imaging ; Male ; Medical sciences ; Neuropsychology ; Psychology. Psychoanalysis. Psychiatry ; Psychopathology. Psychiatry</subject><ispartof>The American journal of psychiatry, 2012-10, Vol.169 (10), p.1109-1116</ispartof><rights>Copyright © 2012 by the American Psychiatric Association 2012</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2012 by the American Psychiatric Association</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a461t-3cebfc78738ffc9534044d24475622f20e1f103872b8fe6b8a0688517ece04863</citedby><cites>FETCH-LOGICAL-a461t-3cebfc78738ffc9534044d24475622f20e1f103872b8fe6b8a0688517ece04863</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://psychiatryonline.org/doi/epdf/10.1176/appi.ajp.2012.12020191$$EPDF$$P50$$Gappi$$H</linktopdf><linktohtml>$$Uhttps://psychiatryonline.org/doi/full/10.1176/appi.ajp.2012.12020191$$EHTML$$P50$$Gappi$$H</linktohtml><link.rule.ids>314,776,780,2842,21605,21606,21607,27901,27902,77536,77541</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=26471558$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23032389$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Viding, Essi</creatorcontrib><creatorcontrib>Sebastian, Catherine L.</creatorcontrib><creatorcontrib>Dadds, Mark R.</creatorcontrib><creatorcontrib>Lockwood, Patricia L.</creatorcontrib><creatorcontrib>Cecil, Charlotte A.M.</creatorcontrib><creatorcontrib>De Brito, Stephane A.</creatorcontrib><creatorcontrib>McCrory, Eamon J.</creatorcontrib><title>Amygdala Response to Preattentive Masked Fear in Children With Conduct Problems: The Role of Callous-Unemotional Traits</title><title>The American journal of psychiatry</title><addtitle>Am J Psychiatry</addtitle><description>ObjectiveIn children with conduct problems, high levels of callous-unemotional traits are associated with amygdala hypoactivity to consciously perceived fear, while low levels of callous-unemotional traits may be associated with amygdala hyperactivity. Behavioral data suggest that fear processing deficits in children with high callous-unemotional traits may extend to stimuli presented below conscious awareness (preattentively). The authors investigated the neural basis of this effect. Amygdala involvement was predicted on the basis of its role in preattentive affective processing in healthy adults and its dysfunction in previous studies of conduct problems.MethodFunctional MRI was used to measure neural responses to fearful and calm faces presented preattentively (for 17 ms followed by backward masking) in boys with conduct problems and high callous-unemotional traits (N=15), conduct problems and low callous-unemotional traits (N=15), and typically developing comparison boys (N=16). Amygdala response to fearful and calm faces was predicted to differentiate groups, with the greatest response in boys with conduct problems and low callous-unemotional traits and the lowest in boys with conduct problems and high callous-unemotional traits.ResultsIn the right amygdala, a greater amygdala response was seen in boys with conduct problems and low callous-unemotional traits than in those with high callous-unemotional traits. The findings were not explained by symptom levels of conduct disorder, attention-deficit hyperactivity disorder, anxiety, or depression.ConclusionsThese data demonstrate differential amygdala activity to preattentively presented fear in children with conduct problems grouped by callous-unemotional traits, with high levels associated with lower amygdala reactivity. The study’s findings complement increasing evidence suggesting that callous-unemotional traits are an important specifier in the classification of children with conduct problems.</description><subject>Adolescent</subject><subject>Amygdala - physiopathology</subject><subject>Attention - physiology</subject><subject>Behavior disorders</subject><subject>Biological and medical sciences</subject><subject>Child</subject><subject>Child & adolescent psychiatry</subject><subject>Conduct Disorder - physiopathology</subject><subject>Conduct Disorder - psychology</subject><subject>Emotions - physiology</subject><subject>Empathy</subject><subject>Facial Expression</subject><subject>Fear & phobias</subject><subject>Fear - physiology</subject><subject>Functional Neuroimaging</subject><subject>Humans</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Neuropsychology</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopathology. Psychiatry</subject><issn>0002-953X</issn><issn>1535-7228</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kV1rFDEUhoModlv9CyUggjez5msmWe_KYKvQUilb9G7IzJy4WTOTaZJR-u_NutsWvOjVIfC857zhQeiUkiWlsvqop8ku9XZaMkLZkjKS54q-QAta8rKQjKmXaEEIYcWq5D-O0HGM2_wkXLLX6IhxwhlXqwX6czbc_-y10_gG4uTHCDh5_C2ATgnGZH8DvtLxF_T4HHTAdsT1xro-wIi_27TBtR_7uUs54VsHQ_yE1xvAN94B9gbX2jk_x-J2hMEn60ft8Dpom-Ib9MpoF-HtYZ6g2_PP6_pLcXl98bU-uyy0qGgqeAet6aSSXBnT5a8IIkTPhJBlxZhhBKihhCvJWmWgapUmlVIlldABEariJ-jDfu8U_N0MMTWDjR04p0fIzRpKFBM5w3hG3_2Hbv0ccuVMcVqWghMiM1XtqS74GAOYZgp20OE-r2p2apqdmiaraXZqmgc1OXh6WD-3A_SPsQcXGXh_AHTstDNBj52NT1wlZG6hMsf33L9DTx2fP_8XtqCoHQ</recordid><startdate>20121001</startdate><enddate>20121001</enddate><creator>Viding, Essi</creator><creator>Sebastian, Catherine L.</creator><creator>Dadds, Mark R.</creator><creator>Lockwood, Patricia L.</creator><creator>Cecil, Charlotte A.M.</creator><creator>De Brito, Stephane A.</creator><creator>McCrory, Eamon J.</creator><general>American Psychiatric Association</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope></search><sort><creationdate>20121001</creationdate><title>Amygdala Response to Preattentive Masked Fear in Children With Conduct Problems: The Role of Callous-Unemotional Traits</title><author>Viding, Essi ; Sebastian, Catherine L. ; Dadds, Mark R. ; Lockwood, Patricia L. ; Cecil, Charlotte A.M. ; De Brito, Stephane A. ; McCrory, Eamon J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a461t-3cebfc78738ffc9534044d24475622f20e1f103872b8fe6b8a0688517ece04863</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Adolescent</topic><topic>Amygdala - physiopathology</topic><topic>Attention - physiology</topic><topic>Behavior disorders</topic><topic>Biological and medical sciences</topic><topic>Child</topic><topic>Child & adolescent psychiatry</topic><topic>Conduct Disorder - physiopathology</topic><topic>Conduct Disorder - psychology</topic><topic>Emotions - physiology</topic><topic>Empathy</topic><topic>Facial Expression</topic><topic>Fear & phobias</topic><topic>Fear - physiology</topic><topic>Functional Neuroimaging</topic><topic>Humans</topic><topic>Magnetic Resonance Imaging</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Neuropsychology</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopathology. Psychiatry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Viding, Essi</creatorcontrib><creatorcontrib>Sebastian, Catherine L.</creatorcontrib><creatorcontrib>Dadds, Mark R.</creatorcontrib><creatorcontrib>Lockwood, Patricia L.</creatorcontrib><creatorcontrib>Cecil, Charlotte A.M.</creatorcontrib><creatorcontrib>De Brito, Stephane A.</creatorcontrib><creatorcontrib>McCrory, Eamon J.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>The American journal of psychiatry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Viding, Essi</au><au>Sebastian, Catherine L.</au><au>Dadds, Mark R.</au><au>Lockwood, Patricia L.</au><au>Cecil, Charlotte A.M.</au><au>De Brito, Stephane A.</au><au>McCrory, Eamon J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Amygdala Response to Preattentive Masked Fear in Children With Conduct Problems: The Role of Callous-Unemotional Traits</atitle><jtitle>The American journal of psychiatry</jtitle><addtitle>Am J Psychiatry</addtitle><date>2012-10-01</date><risdate>2012</risdate><volume>169</volume><issue>10</issue><spage>1109</spage><epage>1116</epage><pages>1109-1116</pages><issn>0002-953X</issn><eissn>1535-7228</eissn><coden>AJPSAO</coden><abstract>ObjectiveIn children with conduct problems, high levels of callous-unemotional traits are associated with amygdala hypoactivity to consciously perceived fear, while low levels of callous-unemotional traits may be associated with amygdala hyperactivity. Behavioral data suggest that fear processing deficits in children with high callous-unemotional traits may extend to stimuli presented below conscious awareness (preattentively). The authors investigated the neural basis of this effect. Amygdala involvement was predicted on the basis of its role in preattentive affective processing in healthy adults and its dysfunction in previous studies of conduct problems.MethodFunctional MRI was used to measure neural responses to fearful and calm faces presented preattentively (for 17 ms followed by backward masking) in boys with conduct problems and high callous-unemotional traits (N=15), conduct problems and low callous-unemotional traits (N=15), and typically developing comparison boys (N=16). Amygdala response to fearful and calm faces was predicted to differentiate groups, with the greatest response in boys with conduct problems and low callous-unemotional traits and the lowest in boys with conduct problems and high callous-unemotional traits.ResultsIn the right amygdala, a greater amygdala response was seen in boys with conduct problems and low callous-unemotional traits than in those with high callous-unemotional traits. The findings were not explained by symptom levels of conduct disorder, attention-deficit hyperactivity disorder, anxiety, or depression.ConclusionsThese data demonstrate differential amygdala activity to preattentively presented fear in children with conduct problems grouped by callous-unemotional traits, with high levels associated with lower amygdala reactivity. The study’s findings complement increasing evidence suggesting that callous-unemotional traits are an important specifier in the classification of children with conduct problems.</abstract><cop>Arlington, VA</cop><pub>American Psychiatric Association</pub><pmid>23032389</pmid><doi>10.1176/appi.ajp.2012.12020191</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adolescent Amygdala - physiopathology Attention - physiology Behavior disorders Biological and medical sciences Child Child & adolescent psychiatry Conduct Disorder - physiopathology Conduct Disorder - psychology Emotions - physiology Empathy Facial Expression Fear & phobias Fear - physiology Functional Neuroimaging Humans Magnetic Resonance Imaging Male Medical sciences Neuropsychology Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry |
| title | Amygdala Response to Preattentive Masked Fear in Children With Conduct Problems: The Role of Callous-Unemotional Traits |
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