Paracetamol and simvastatin: a potential interaction resulting in hepatotoxicity

The safety profile of paracetamol and simvastatin is sufficiently well known, although no interactions between these two medicinal products have been described in the scientific literature so far. A 66-year-old female patient who experienced myocardial infarction and underwent coronary artery bypass...

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Veröffentlicht in:	Medicina (Kaunas, Lithuania) Lithuania), 2012-01, Vol.48 (7), p.379-381
Hauptverfasser:	Gumbrevičius, Gintautas, Sveikata, Audrius, Sveikatienė, Renata, Stankevičius, Edgaras
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetaminophen - administration & dosage Acetaminophen - adverse effects Aged Analgesics, Non-Narcotic - administration & dosage Analgesics, Non-Narcotic - adverse effects Coronary Artery Bypass Cytochrome P-450 CYP3A - metabolism Drug Interactions Female Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors - administration & dosage Hydroxymethylglutaryl-CoA Reductase Inhibitors - adverse effects Jaundice - chemically induced Liver - drug effects Liver - enzymology Myocardial Infarction - prevention & control Myocardial Infarction - surgery Nausea - chemically induced Simvastatin - administration & dosage Simvastatin - adverse effects Vomiting - chemically induced
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