Agreement between colposcopic impression and histological diagnosis among human papillomavirus type 16-positive women: a clinical trial using dynamic spectral imaging colposcopy
Please cite this paper as: Zaal A, Louwers J, Berkhof J, Kocken M, ter Harmsel W, Graziosi G, Spruijt J, Balas C, Papagiannakis E, Snijders P, Meijer C, van Kemenade F, Verheijen R. Agreement between colposcopic impression and histological diagnosis among human papillomavirus type 16‐positive women:...
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| Veröffentlicht in: | BJOG : an international journal of obstetrics and gynaecology 2012-04, Vol.119 (5), p.537-544 |
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| container_title | BJOG : an international journal of obstetrics and gynaecology |
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| creator | Zaal, A Louwers, JA Berkhof, J Kocken, M ter Harmsel, WA Graziosi, GCM Spruijt, JWM Balas, C Papagiannakis, E Snijders, PJF Meijer, CJLM van Kemenade, FJ Verheijen, RHM |
| description | Please cite this paper as: Zaal A, Louwers J, Berkhof J, Kocken M, ter Harmsel W, Graziosi G, Spruijt J, Balas C, Papagiannakis E, Snijders P, Meijer C, van Kemenade F, Verheijen R. Agreement between colposcopic impression and histological diagnosis among human papillomavirus type 16‐positive women: a clinical trial using dynamic spectral imaging colposcopy. BJOG 2012;119:537–544.
Objective To investigate the agreement between conventional colposcopic impression, dynamic spectral imaging (DSI) colposcopy and histology, for human papillomavirus type 16‐positive (HPV16+) and non‐16 high‐risk (hr) HPV+ women.
Design Prospective, comparative, multicentre clinical trial.
Setting Three colposcopy clinics in the Netherlands.
Population Women (n = 177) aged 18 years or over with an intact cervix, referred for colposcopy.
Methods The colposcopist graded the lesion by using the DSI colposcope as a regular video colposcope. Subsequently the DSI impression was displayed and biopsies were taken from all abnormal areas as well as from a random (normal) site. A cervical smear was taken for HPV typing.
Main outcome measures Histologically confirmed high‐grade cervical intraepithelial neoplasia or cancer (CIN2+), positive for HPV16 or for any other hrHPV type.
Results The DSI colposcope identified more CIN2+ cervical lesions among HPV16+ women than in non‐16 hrHPV+ women (P = 0.032 regardless of final histology and P = 0.009 among women with CIN2+). Consequently, the sensitivity of the DSI colposcope for detecting CIN2+ lesions was higher in HPV16+ women than in non‐16 hrHPV+ women (97% versus 74%, P = 0.009). No such differences were seen for the colposcopist impression. In addition, mainly smaller cervical lesions are missed by the colposcopist.
Conclusions The sensitivity of DSI colposcopy for CIN2+ is higher in HPV16+ than in non‐16 hrHPV+ women. Furthermore, regardless of HPV16 status, the sensitivity of DSI for CIN2+ is higher than that of the colposcopist, probably because colposcopists tend to miss smaller cervical lesions. |
| doi_str_mv | 10.1111/j.1471-0528.2012.03280.x |
| format | Article |
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Objective To investigate the agreement between conventional colposcopic impression, dynamic spectral imaging (DSI) colposcopy and histology, for human papillomavirus type 16‐positive (HPV16+) and non‐16 high‐risk (hr) HPV+ women.
Design Prospective, comparative, multicentre clinical trial.
Setting Three colposcopy clinics in the Netherlands.
Population Women (n = 177) aged 18 years or over with an intact cervix, referred for colposcopy.
Methods The colposcopist graded the lesion by using the DSI colposcope as a regular video colposcope. Subsequently the DSI impression was displayed and biopsies were taken from all abnormal areas as well as from a random (normal) site. A cervical smear was taken for HPV typing.
Main outcome measures Histologically confirmed high‐grade cervical intraepithelial neoplasia or cancer (CIN2+), positive for HPV16 or for any other hrHPV type.
Results The DSI colposcope identified more CIN2+ cervical lesions among HPV16+ women than in non‐16 hrHPV+ women (P = 0.032 regardless of final histology and P = 0.009 among women with CIN2+). Consequently, the sensitivity of the DSI colposcope for detecting CIN2+ lesions was higher in HPV16+ women than in non‐16 hrHPV+ women (97% versus 74%, P = 0.009). No such differences were seen for the colposcopist impression. In addition, mainly smaller cervical lesions are missed by the colposcopist.
Conclusions The sensitivity of DSI colposcopy for CIN2+ is higher in HPV16+ than in non‐16 hrHPV+ women. Furthermore, regardless of HPV16 status, the sensitivity of DSI for CIN2+ is higher than that of the colposcopist, probably because colposcopists tend to miss smaller cervical lesions.</description><identifier>ISSN: 1470-0328</identifier><identifier>EISSN: 1471-0528</identifier><identifier>DOI: 10.1111/j.1471-0528.2012.03280.x</identifier><identifier>PMID: 22304443</identifier><identifier>CODEN: BIOGFQ</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Adolescent ; Adult ; Biological and medical sciences ; Biopsy ; Cervical cancer ; Cervical intraepithelial neoplasia ; Cervical Intraepithelial Neoplasia - pathology ; Cervical Intraepithelial Neoplasia - virology ; Clinical trials ; Colposcopes - standards ; Colposcopy ; Colposcopy - instrumentation ; Colposcopy - methods ; Colposcopy - standards ; Computed tomography ; Diagnostic tests ; Female ; Gynecology. Andrology. Obstetrics ; Human papillomavirus ; Human papillomavirus 16 ; Humans ; Medical sciences ; Middle Aged ; Papillomavirus Infections - pathology ; Papillomavirus Infections - virology ; Prospective Studies ; Risk groups ; Sensitivity and Specificity ; spectrometry ; Typing ; Uterine Cervical Neoplasms - pathology ; Uterine Cervical Neoplasms - virology ; Vaginal Smears ; Young Adult</subject><ispartof>BJOG : an international journal of obstetrics and gynaecology, 2012-04, Vol.119 (5), p.537-544</ispartof><rights>2012 The Authors BJOG An International Journal of Obstetrics and Gynaecology © 2012 RCOG</rights><rights>2015 INIST-CNRS</rights><rights>2012 The Authors BJOG An International Journal of Obstetrics and Gynaecology © 2012 RCOG.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4970-a380b71dad09b90ecb82eb3914e791946f1fc54af1d5767dcf14b5c75cc0ba893</citedby><cites>FETCH-LOGICAL-c4970-a380b71dad09b90ecb82eb3914e791946f1fc54af1d5767dcf14b5c75cc0ba893</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1471-0528.2012.03280.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1471-0528.2012.03280.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,777,781,1412,27905,27906,45555,45556</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=25588740$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22304443$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zaal, A</creatorcontrib><creatorcontrib>Louwers, JA</creatorcontrib><creatorcontrib>Berkhof, J</creatorcontrib><creatorcontrib>Kocken, M</creatorcontrib><creatorcontrib>ter Harmsel, WA</creatorcontrib><creatorcontrib>Graziosi, GCM</creatorcontrib><creatorcontrib>Spruijt, JWM</creatorcontrib><creatorcontrib>Balas, C</creatorcontrib><creatorcontrib>Papagiannakis, E</creatorcontrib><creatorcontrib>Snijders, PJF</creatorcontrib><creatorcontrib>Meijer, CJLM</creatorcontrib><creatorcontrib>van Kemenade, FJ</creatorcontrib><creatorcontrib>Verheijen, RHM</creatorcontrib><title>Agreement between colposcopic impression and histological diagnosis among human papillomavirus type 16-positive women: a clinical trial using dynamic spectral imaging colposcopy</title><title>BJOG : an international journal of obstetrics and gynaecology</title><addtitle>BJOG</addtitle><description>Please cite this paper as: Zaal A, Louwers J, Berkhof J, Kocken M, ter Harmsel W, Graziosi G, Spruijt J, Balas C, Papagiannakis E, Snijders P, Meijer C, van Kemenade F, Verheijen R. Agreement between colposcopic impression and histological diagnosis among human papillomavirus type 16‐positive women: a clinical trial using dynamic spectral imaging colposcopy. BJOG 2012;119:537–544.
Objective To investigate the agreement between conventional colposcopic impression, dynamic spectral imaging (DSI) colposcopy and histology, for human papillomavirus type 16‐positive (HPV16+) and non‐16 high‐risk (hr) HPV+ women.
Design Prospective, comparative, multicentre clinical trial.
Setting Three colposcopy clinics in the Netherlands.
Population Women (n = 177) aged 18 years or over with an intact cervix, referred for colposcopy.
Methods The colposcopist graded the lesion by using the DSI colposcope as a regular video colposcope. Subsequently the DSI impression was displayed and biopsies were taken from all abnormal areas as well as from a random (normal) site. A cervical smear was taken for HPV typing.
Main outcome measures Histologically confirmed high‐grade cervical intraepithelial neoplasia or cancer (CIN2+), positive for HPV16 or for any other hrHPV type.
Results The DSI colposcope identified more CIN2+ cervical lesions among HPV16+ women than in non‐16 hrHPV+ women (P = 0.032 regardless of final histology and P = 0.009 among women with CIN2+). Consequently, the sensitivity of the DSI colposcope for detecting CIN2+ lesions was higher in HPV16+ women than in non‐16 hrHPV+ women (97% versus 74%, P = 0.009). No such differences were seen for the colposcopist impression. In addition, mainly smaller cervical lesions are missed by the colposcopist.
Conclusions The sensitivity of DSI colposcopy for CIN2+ is higher in HPV16+ than in non‐16 hrHPV+ women. Furthermore, regardless of HPV16 status, the sensitivity of DSI for CIN2+ is higher than that of the colposcopist, probably because colposcopists tend to miss smaller cervical lesions.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Biopsy</subject><subject>Cervical cancer</subject><subject>Cervical intraepithelial neoplasia</subject><subject>Cervical Intraepithelial Neoplasia - pathology</subject><subject>Cervical Intraepithelial Neoplasia - virology</subject><subject>Clinical trials</subject><subject>Colposcopes - standards</subject><subject>Colposcopy</subject><subject>Colposcopy - instrumentation</subject><subject>Colposcopy - methods</subject><subject>Colposcopy - standards</subject><subject>Computed tomography</subject><subject>Diagnostic tests</subject><subject>Female</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Human papillomavirus</subject><subject>Human papillomavirus 16</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Papillomavirus Infections - pathology</subject><subject>Papillomavirus Infections - virology</subject><subject>Prospective Studies</subject><subject>Risk groups</subject><subject>Sensitivity and Specificity</subject><subject>spectrometry</subject><subject>Typing</subject><subject>Uterine Cervical Neoplasms - pathology</subject><subject>Uterine Cervical Neoplasms - virology</subject><subject>Vaginal Smears</subject><subject>Young Adult</subject><issn>1470-0328</issn><issn>1471-0528</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkttu1DAQhiMEogd4BWQhIXGTYDt2DkhclIoWqqq9AXppOc4k9ZLYwU66m8fqG-LsLovEDcRSbHm-_7c9M1GECE5I-N6tEsJyEmNOi4RiQhOc0gInmyfR8SHwdLvG8RI6ik68X2FMMorT59ERpSlmjKXH0eNZ6wB6MCOqYFwDGKRsN1iv7KAV0v3gwHttDZKmRvfaj7azrVayQ7WWrbFeeyR7a1p0P_XSoEEOuutsLx-0mzwa5wEQyeLgqEf9AGhtw2HvkUSq02brMzod_pPXwaOejezDuX4ANbqwrXvZLoHDpeYX0bNGdh5e7ufT6NvFp6_nn-Pr28sv52fXsWJleLZMC1zlpJY1LqsSg6oKClVaEgZ5SUqWNaRRnMmG1DzP8lo1hFVc5VwpXMmiTE-jtzvfwdmfE_hR9Nor6DppwE5eEFxQhlkW0vhvlOKCZyVeXF__ha7s5Ex4iChpzsNIswAVO0g5672DRgwuJMLNwUksDSBWYqmzWOoslgYQ2wYQmyB9tfefqh7qg_B3xQPwZg9IH7LfOGmU9n84zosiZzhwH3bcWncw__cFxMer22UV9PFOH1oGNge9dD9Elqc5F3c3l6L8TrMbfnUnLtJf2EHewA</recordid><startdate>201204</startdate><enddate>201204</enddate><creator>Zaal, A</creator><creator>Louwers, JA</creator><creator>Berkhof, J</creator><creator>Kocken, M</creator><creator>ter Harmsel, WA</creator><creator>Graziosi, GCM</creator><creator>Spruijt, JWM</creator><creator>Balas, C</creator><creator>Papagiannakis, E</creator><creator>Snijders, PJF</creator><creator>Meijer, CJLM</creator><creator>van Kemenade, FJ</creator><creator>Verheijen, RHM</creator><general>Blackwell Publishing Ltd</general><general>Blackwell</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>ASE</scope><scope>FPQ</scope><scope>K6X</scope><scope>K9.</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>201204</creationdate><title>Agreement between colposcopic impression and histological diagnosis among human papillomavirus type 16-positive women: a clinical trial using dynamic spectral imaging colposcopy</title><author>Zaal, A ; Louwers, JA ; Berkhof, J ; Kocken, M ; ter Harmsel, WA ; Graziosi, GCM ; Spruijt, JWM ; Balas, C ; Papagiannakis, E ; Snijders, PJF ; Meijer, CJLM ; van Kemenade, FJ ; Verheijen, RHM</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4970-a380b71dad09b90ecb82eb3914e791946f1fc54af1d5767dcf14b5c75cc0ba893</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Biopsy</topic><topic>Cervical cancer</topic><topic>Cervical intraepithelial neoplasia</topic><topic>Cervical Intraepithelial Neoplasia - pathology</topic><topic>Cervical Intraepithelial Neoplasia - virology</topic><topic>Clinical trials</topic><topic>Colposcopes - standards</topic><topic>Colposcopy</topic><topic>Colposcopy - instrumentation</topic><topic>Colposcopy - methods</topic><topic>Colposcopy - standards</topic><topic>Computed tomography</topic><topic>Diagnostic tests</topic><topic>Female</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Human papillomavirus</topic><topic>Human papillomavirus 16</topic><topic>Humans</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Papillomavirus Infections - pathology</topic><topic>Papillomavirus Infections - virology</topic><topic>Prospective Studies</topic><topic>Risk groups</topic><topic>Sensitivity and Specificity</topic><topic>spectrometry</topic><topic>Typing</topic><topic>Uterine Cervical Neoplasms - pathology</topic><topic>Uterine Cervical Neoplasms - virology</topic><topic>Vaginal Smears</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zaal, A</creatorcontrib><creatorcontrib>Louwers, JA</creatorcontrib><creatorcontrib>Berkhof, J</creatorcontrib><creatorcontrib>Kocken, M</creatorcontrib><creatorcontrib>ter Harmsel, WA</creatorcontrib><creatorcontrib>Graziosi, GCM</creatorcontrib><creatorcontrib>Spruijt, JWM</creatorcontrib><creatorcontrib>Balas, C</creatorcontrib><creatorcontrib>Papagiannakis, E</creatorcontrib><creatorcontrib>Snijders, PJF</creatorcontrib><creatorcontrib>Meijer, CJLM</creatorcontrib><creatorcontrib>van Kemenade, FJ</creatorcontrib><creatorcontrib>Verheijen, RHM</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>British Nursing Index</collection><collection>British Nursing Index (BNI) (1985 to Present)</collection><collection>British Nursing Index</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>BJOG : an international journal of obstetrics and gynaecology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zaal, A</au><au>Louwers, JA</au><au>Berkhof, J</au><au>Kocken, M</au><au>ter Harmsel, WA</au><au>Graziosi, GCM</au><au>Spruijt, JWM</au><au>Balas, C</au><au>Papagiannakis, E</au><au>Snijders, PJF</au><au>Meijer, CJLM</au><au>van Kemenade, FJ</au><au>Verheijen, RHM</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Agreement between colposcopic impression and histological diagnosis among human papillomavirus type 16-positive women: a clinical trial using dynamic spectral imaging colposcopy</atitle><jtitle>BJOG : an international journal of obstetrics and gynaecology</jtitle><addtitle>BJOG</addtitle><date>2012-04</date><risdate>2012</risdate><volume>119</volume><issue>5</issue><spage>537</spage><epage>544</epage><pages>537-544</pages><issn>1470-0328</issn><eissn>1471-0528</eissn><coden>BIOGFQ</coden><abstract>Please cite this paper as: Zaal A, Louwers J, Berkhof J, Kocken M, ter Harmsel W, Graziosi G, Spruijt J, Balas C, Papagiannakis E, Snijders P, Meijer C, van Kemenade F, Verheijen R. Agreement between colposcopic impression and histological diagnosis among human papillomavirus type 16‐positive women: a clinical trial using dynamic spectral imaging colposcopy. BJOG 2012;119:537–544.
Objective To investigate the agreement between conventional colposcopic impression, dynamic spectral imaging (DSI) colposcopy and histology, for human papillomavirus type 16‐positive (HPV16+) and non‐16 high‐risk (hr) HPV+ women.
Design Prospective, comparative, multicentre clinical trial.
Setting Three colposcopy clinics in the Netherlands.
Population Women (n = 177) aged 18 years or over with an intact cervix, referred for colposcopy.
Methods The colposcopist graded the lesion by using the DSI colposcope as a regular video colposcope. Subsequently the DSI impression was displayed and biopsies were taken from all abnormal areas as well as from a random (normal) site. A cervical smear was taken for HPV typing.
Main outcome measures Histologically confirmed high‐grade cervical intraepithelial neoplasia or cancer (CIN2+), positive for HPV16 or for any other hrHPV type.
Results The DSI colposcope identified more CIN2+ cervical lesions among HPV16+ women than in non‐16 hrHPV+ women (P = 0.032 regardless of final histology and P = 0.009 among women with CIN2+). Consequently, the sensitivity of the DSI colposcope for detecting CIN2+ lesions was higher in HPV16+ women than in non‐16 hrHPV+ women (97% versus 74%, P = 0.009). No such differences were seen for the colposcopist impression. In addition, mainly smaller cervical lesions are missed by the colposcopist.
Conclusions The sensitivity of DSI colposcopy for CIN2+ is higher in HPV16+ than in non‐16 hrHPV+ women. Furthermore, regardless of HPV16 status, the sensitivity of DSI for CIN2+ is higher than that of the colposcopist, probably because colposcopists tend to miss smaller cervical lesions.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>22304443</pmid><doi>10.1111/j.1471-0528.2012.03280.x</doi><tpages>8</tpages></addata></record> |
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| ispartof | BJOG : an international journal of obstetrics and gynaecology, 2012-04, Vol.119 (5), p.537-544 |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Adolescent Adult Biological and medical sciences Biopsy Cervical cancer Cervical intraepithelial neoplasia Cervical Intraepithelial Neoplasia - pathology Cervical Intraepithelial Neoplasia - virology Clinical trials Colposcopes - standards Colposcopy Colposcopy - instrumentation Colposcopy - methods Colposcopy - standards Computed tomography Diagnostic tests Female Gynecology. Andrology. Obstetrics Human papillomavirus Human papillomavirus 16 Humans Medical sciences Middle Aged Papillomavirus Infections - pathology Papillomavirus Infections - virology Prospective Studies Risk groups Sensitivity and Specificity spectrometry Typing Uterine Cervical Neoplasms - pathology Uterine Cervical Neoplasms - virology Vaginal Smears Young Adult |
| title | Agreement between colposcopic impression and histological diagnosis among human papillomavirus type 16-positive women: a clinical trial using dynamic spectral imaging colposcopy |
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