Functional TRPV6 channels are crucial for transepithelial Ca2+ absorption

TRPV6 is considered the primary protein responsible for transcellular Ca2+ absorption. In vitro studies demonstrate that a negatively charged amino acid (D) within the putative pore region of mouse TRPV6 (position 541) is critical for Ca2+ permeation of the channel. To elucidate the role of TRPV6 in...

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Veröffentlicht in:	American journal of physiology: Gastrointestinal and liver physiology 2012-10, Vol.303 (7), p.G879-G885
Hauptverfasser:	Woudenberg-Vrenken, Titia E, Lameris, Anke L, Weißgerber, Petra, Olausson, Jenny, Flockerzi, Veit, Bindels, René J M, Freichel, Marc, Hoenderop, Joost G J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Calbindins Calcium - blood Calcium - pharmacokinetics Calcium Channels - metabolism Calcium-Binding Proteins - metabolism Diet - adverse effects Diet - methods Hypocalcemia - metabolism Intestinal Absorption - physiology Intestinal Mucosa - physiology Kidney - metabolism Mice Mice, Knockout S100 Calcium Binding Protein G - metabolism Transcytosis TRPV Cation Channels - genetics TRPV Cation Channels - metabolism
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