Semi-automated in vivo solid-phase microextraction sampling and the diffusion-based interface calibration model to determine the pharmacokinetics of methoxyfenoterol and fenoterol in rats

[Display omitted] ► In vivo SPME was used for PK studies of fenoterol and methoxyfenoterol in rats. ► New diffusion-based calibration interface model was used for calibration. ► Automated sampling system was used for in vivo studies. ► This is the first time in vivo SPME was successfully used for st...

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Veröffentlicht in:	Analytica chimica acta 2012-09, Vol.742, p.37-44
Hauptverfasser:	Yeung, Joanne Chung Yan, de Lannoy, Inés, Gien, Brad, Vuckovic, Dajana, Yang, Yingbo, Bojko, Barbara, Pawliszyn, Janusz
Format:	Artikel
Sprache:	eng
Schlagworte:	Analytical chemistry Animals Automation Biocompatibility Biomedical materials Blood Blood Specimen Collection Bronchodilator Agents - administration & dosage Bronchodilator Agents - blood Bronchodilator Agents - pharmacokinetics Calibration Chemistry Chromatographic methods and physical methods associated with chromatography Chromatography, Liquid Diffusion Diffusion-based calibration Exact sciences and technology Fenoterol Fenoterol - administration & dosage Fenoterol - analogs & derivatives Fenoterol - blood Fenoterol - pharmacokinetics In vivo solid-phase microextraction In vivo testing In vivo tests Injections, Intravenous Male Methoxyfenoterol Other chromatographic methods Pharmacokinetics studies Rats Rats, Sprague-Dawley Sampling Solid Phase Microextraction - methods Specimen Handling - methods Spectrometric and optical methods Surgical implants Tandem Mass Spectrometry
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