Osteogenic effect of fluvastatin combined with biodegradable gelatin-hydrogel
The aim was to investigate the local osteogenic effect of fluvastatin incorporated into a biodegradable gelatin-hydrogel (GH) scaffold. The GH scaffolds were prepared through crosslinking by ultraviolet irradiation followed by freeze-drying. Two circular defects were surgically created on fifteen-we...
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| Veröffentlicht in: | Dental Materials Journal 2012, Vol.31(3), pp.489-493 |
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| container_end_page | 493 |
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| container_issue | 3 |
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| container_title | Dental Materials Journal |
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| creator | TANABE, Koji NOMOTO, Hideki OKUMORI, Naoto MIURA, Tadashi YOSHINARI, Masao |
| description | The aim was to investigate the local osteogenic effect of fluvastatin incorporated into a biodegradable gelatin-hydrogel (GH) scaffold. The GH scaffolds were prepared through crosslinking by ultraviolet irradiation followed by freeze-drying. Two circular defects were surgically created on fifteen-week-old male rats calvaria. All defects of each rat were randomly filled with two of three treatments, specifically: fluvastatin incorporated into a GH disk (Flu-GH), distilled water incorporated into a GH disk, and no treatment. New bone formation was quantitatively analyzed after 7, 14, and 28 days using a micro-computed tomography (micro-CT) system, and histologically observed. Evaluation by micro-CT revealed a significant difference in new bone formation among the three kinds of defect. A highly osteogenic effect was observed in the Flu-GH group. The results showed that the fluvastatin incorporated into a biodegradable GH scaffold promoted osteogenesis in rat calvarial bone, indicating its potential for bone regeneration. |
| doi_str_mv | 10.4012/dmj.2012-008 |
| format | Article |
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The GH scaffolds were prepared through crosslinking by ultraviolet irradiation followed by freeze-drying. Two circular defects were surgically created on fifteen-week-old male rats calvaria. All defects of each rat were randomly filled with two of three treatments, specifically: fluvastatin incorporated into a GH disk (Flu-GH), distilled water incorporated into a GH disk, and no treatment. New bone formation was quantitatively analyzed after 7, 14, and 28 days using a micro-computed tomography (micro-CT) system, and histologically observed. Evaluation by micro-CT revealed a significant difference in new bone formation among the three kinds of defect. A highly osteogenic effect was observed in the Flu-GH group. The results showed that the fluvastatin incorporated into a biodegradable GH scaffold promoted osteogenesis in rat calvarial bone, indicating its potential for bone regeneration.</description><identifier>ISSN: 0287-4547</identifier><identifier>EISSN: 1881-1361</identifier><identifier>DOI: 10.4012/dmj.2012-008</identifier><identifier>PMID: 22673476</identifier><language>eng</language><publisher>Japan: The Japanese Society for Dental Materials and Devices</publisher><subject>Absorbable Implants ; Animals ; Bone Regeneration - drug effects ; Dentistry ; Fatty Acids, Monounsaturated - pharmacology ; Fluvastatin ; Hydrogels ; Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology ; Indoles - pharmacology ; Male ; Osteogenesis - drug effects ; Osteogenic ; Random Allocation ; Rats ; Rats, Sprague-Dawley ; Scaffold ; Skull - surgery ; Tissue Scaffolds ; Water ; X-Ray Microtomography</subject><ispartof>Dental Materials Journal, 2012, Vol.31(3), pp.489-493</ispartof><rights>2012 The Japanese Society for Dental Materials and Devices</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c485t-50c5cd653ec1f3fa5f906cea6b8c982d691bd15be19ccd9fae2685eba04800843</citedby><cites>FETCH-LOGICAL-c485t-50c5cd653ec1f3fa5f906cea6b8c982d691bd15be19ccd9fae2685eba04800843</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,1884,4025,27925,27926,27927</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22673476$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>TANABE, Koji</creatorcontrib><creatorcontrib>NOMOTO, Hideki</creatorcontrib><creatorcontrib>OKUMORI, Naoto</creatorcontrib><creatorcontrib>MIURA, Tadashi</creatorcontrib><creatorcontrib>YOSHINARI, Masao</creatorcontrib><title>Osteogenic effect of fluvastatin combined with biodegradable gelatin-hydrogel</title><title>Dental Materials Journal</title><addtitle>Dent. Mater. J.</addtitle><description>The aim was to investigate the local osteogenic effect of fluvastatin incorporated into a biodegradable gelatin-hydrogel (GH) scaffold. The GH scaffolds were prepared through crosslinking by ultraviolet irradiation followed by freeze-drying. Two circular defects were surgically created on fifteen-week-old male rats calvaria. All defects of each rat were randomly filled with two of three treatments, specifically: fluvastatin incorporated into a GH disk (Flu-GH), distilled water incorporated into a GH disk, and no treatment. New bone formation was quantitatively analyzed after 7, 14, and 28 days using a micro-computed tomography (micro-CT) system, and histologically observed. Evaluation by micro-CT revealed a significant difference in new bone formation among the three kinds of defect. A highly osteogenic effect was observed in the Flu-GH group. The results showed that the fluvastatin incorporated into a biodegradable GH scaffold promoted osteogenesis in rat calvarial bone, indicating its potential for bone regeneration.</description><subject>Absorbable Implants</subject><subject>Animals</subject><subject>Bone Regeneration - drug effects</subject><subject>Dentistry</subject><subject>Fatty Acids, Monounsaturated - pharmacology</subject><subject>Fluvastatin</subject><subject>Hydrogels</subject><subject>Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology</subject><subject>Indoles - pharmacology</subject><subject>Male</subject><subject>Osteogenesis - drug effects</subject><subject>Osteogenic</subject><subject>Random Allocation</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Scaffold</subject><subject>Skull - surgery</subject><subject>Tissue Scaffolds</subject><subject>Water</subject><subject>X-Ray Microtomography</subject><issn>0287-4547</issn><issn>1881-1361</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkLtOwzAUQC0EoqWwMaOMDKT4FccZoeIlFXWB2XLs6zZVHsVOQf17XPqYWWxLPjq69yB0TfCYY0LvbbMc0_hIMZYnaEikJClhgpyiIaYyT3nG8wG6CGGJMS-ElOdoQKnIGc_FEL3PQg_dHNrKJOAcmD7pXOLq9bcOve6rNjFdU1Yt2OSn6hdJWXUW5l5bXdaQzKHeMuliY32U1JfozOk6wNX-HqHP56ePyWs6nb28TR6mqeEy69MMm8xYkTEwxDGnM1dgYUCLUppCUisKUlqSlUAKY2zhNFAhMyg15jJuydkI3e68K999rSH0qqmCgbrWLXTroAiWlOKc5fIfKKWSi9gmonc71PguBA9OrXzVaL-JkNq2VrG12rZWcYqI3-zN67IBe4QPcSPwuAOWMeUcjoD2fWVq-LMxotj2OFiPn2ahvYKW_QLjKpI5</recordid><startdate>2012</startdate><enddate>2012</enddate><creator>TANABE, Koji</creator><creator>NOMOTO, Hideki</creator><creator>OKUMORI, Naoto</creator><creator>MIURA, Tadashi</creator><creator>YOSHINARI, Masao</creator><general>The Japanese Society for Dental Materials and Devices</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7QO</scope><scope>7QP</scope><scope>7T7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope></search><sort><creationdate>2012</creationdate><title>Osteogenic effect of fluvastatin combined with biodegradable gelatin-hydrogel</title><author>TANABE, Koji ; NOMOTO, Hideki ; OKUMORI, Naoto ; MIURA, Tadashi ; YOSHINARI, Masao</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c485t-50c5cd653ec1f3fa5f906cea6b8c982d691bd15be19ccd9fae2685eba04800843</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Absorbable Implants</topic><topic>Animals</topic><topic>Bone Regeneration - drug effects</topic><topic>Dentistry</topic><topic>Fatty Acids, Monounsaturated - pharmacology</topic><topic>Fluvastatin</topic><topic>Hydrogels</topic><topic>Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology</topic><topic>Indoles - pharmacology</topic><topic>Male</topic><topic>Osteogenesis - drug effects</topic><topic>Osteogenic</topic><topic>Random Allocation</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Scaffold</topic><topic>Skull - surgery</topic><topic>Tissue Scaffolds</topic><topic>Water</topic><topic>X-Ray Microtomography</topic><toplevel>online_resources</toplevel><creatorcontrib>TANABE, Koji</creatorcontrib><creatorcontrib>NOMOTO, Hideki</creatorcontrib><creatorcontrib>OKUMORI, Naoto</creatorcontrib><creatorcontrib>MIURA, Tadashi</creatorcontrib><creatorcontrib>YOSHINARI, Masao</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Biotechnology Research Abstracts</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Dental Materials Journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>TANABE, Koji</au><au>NOMOTO, Hideki</au><au>OKUMORI, Naoto</au><au>MIURA, Tadashi</au><au>YOSHINARI, Masao</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Osteogenic effect of fluvastatin combined with biodegradable gelatin-hydrogel</atitle><jtitle>Dental Materials Journal</jtitle><addtitle>Dent. Mater. J.</addtitle><date>2012</date><risdate>2012</risdate><volume>31</volume><issue>3</issue><spage>489</spage><epage>493</epage><pages>489-493</pages><issn>0287-4547</issn><eissn>1881-1361</eissn><abstract>The aim was to investigate the local osteogenic effect of fluvastatin incorporated into a biodegradable gelatin-hydrogel (GH) scaffold. The GH scaffolds were prepared through crosslinking by ultraviolet irradiation followed by freeze-drying. Two circular defects were surgically created on fifteen-week-old male rats calvaria. All defects of each rat were randomly filled with two of three treatments, specifically: fluvastatin incorporated into a GH disk (Flu-GH), distilled water incorporated into a GH disk, and no treatment. New bone formation was quantitatively analyzed after 7, 14, and 28 days using a micro-computed tomography (micro-CT) system, and histologically observed. Evaluation by micro-CT revealed a significant difference in new bone formation among the three kinds of defect. A highly osteogenic effect was observed in the Flu-GH group. The results showed that the fluvastatin incorporated into a biodegradable GH scaffold promoted osteogenesis in rat calvarial bone, indicating its potential for bone regeneration.</abstract><cop>Japan</cop><pub>The Japanese Society for Dental Materials and Devices</pub><pmid>22673476</pmid><doi>10.4012/dmj.2012-008</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| source | J-STAGE Free; MEDLINE; EZB-FREE-00999 freely available EZB journals |
| subjects | Absorbable Implants Animals Bone Regeneration - drug effects Dentistry Fatty Acids, Monounsaturated - pharmacology Fluvastatin Hydrogels Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology Indoles - pharmacology Male Osteogenesis - drug effects Osteogenic Random Allocation Rats Rats, Sprague-Dawley Scaffold Skull - surgery Tissue Scaffolds Water X-Ray Microtomography |
| title | Osteogenic effect of fluvastatin combined with biodegradable gelatin-hydrogel |
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