Sexual dysfunction in people with prodromal or first-episode psychosis
Sexual dysfunction is common in psychotic disorder but it is not clear whether it is intrinsic to the development of the illness or secondary to other factors. To compare sexual function in people at ultra-high risk (UHR) of a psychotic disorder, patients with first-episode psychosis predominantly t...
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| Veröffentlicht in: | British journal of psychiatry 2012-08, Vol.201 (2), p.131-136 |
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| container_title | British journal of psychiatry |
| container_volume | 201 |
| creator | Marques, Tiago Reis Smith, Shubulade Bonaccorso, Stefania Gaughran, Fiona Kolliakou, Anna Dazzan, Paola Mondelli, Valeria Taylor, Heather Diforti, Marta McGuire, Philip K Murray, Robin M Howes, Oliver D |
| description | Sexual dysfunction is common in psychotic disorder but it is not clear whether it is intrinsic to the development of the illness or secondary to other factors.
To compare sexual function in people at ultra-high risk (UHR) of a psychotic disorder, patients with first-episode psychosis predominantly taking antipsychotic drugs and healthy volunteers.
Sexual function was assessed in a UHR group (n = 31), a group with first-episode psychosis (n = 37) and a matched control group of healthy volunteers (n = 56) using the Sexual Function Questionnaire.
There was a significant effect of group on sexual function (P |
| doi_str_mv | 10.1192/bjp.bp.111.101220 |
| format | Article |
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To compare sexual function in people at ultra-high risk (UHR) of a psychotic disorder, patients with first-episode psychosis predominantly taking antipsychotic drugs and healthy volunteers.
Sexual function was assessed in a UHR group (n = 31), a group with first-episode psychosis (n = 37) and a matched control group of healthy volunteers (n = 56) using the Sexual Function Questionnaire.
There was a significant effect of group on sexual function (P<0.001). Sexual dysfunction was evident in 50% of the UHR group, 65% of first-episode patients and 21% of controls. Within the UHR group, sexual dysfunction was more marked in those who subsequently developed psychosis than in those who did not. Across all groups the severity of sexual dysfunction was correlated with the severity of psychotic symptoms (P<0.001). Within the first-episode group there was no significant difference in sexual dysfunction between patients taking prolactin-raising v. prolactin-sparing antipsychotics.
Sexual dysfunction is present prior to onset of psychosis, suggesting it is intrinsic to the development of illness unlikely to be related to the prolactin-raising properties of antipsychotic medication.</description><identifier>ISSN: 0007-1250</identifier><identifier>EISSN: 1472-1465</identifier><identifier>DOI: 10.1192/bjp.bp.111.101220</identifier><identifier>PMID: 22700081</identifier><identifier>CODEN: BJPYAJ</identifier><language>eng</language><publisher>England</publisher><subject>Adult ; Antipsychotic Agents - adverse effects ; Antipsychotic drugs ; Case-Control Studies ; Female ; First time ; Humans ; Lectures ; Male ; Property ; Psychoses ; Psychotic Disorders - complications ; Psychotic Disorders - drug therapy ; Relatives ; Risk Factors ; Severity ; Sexual dysfunction ; Sexual Dysfunction, Physiological - psychology ; Sexual Dysfunctions, Psychological - psychology ; Surveys and Questionnaires ; Volunteers</subject><ispartof>British journal of psychiatry, 2012-08, Vol.201 (2), p.131-136</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c377t-193e60d0eefbb675f82853e32899ecdd3c3af90b22ced55e0b1117fe87d910243</citedby><cites>FETCH-LOGICAL-c377t-193e60d0eefbb675f82853e32899ecdd3c3af90b22ced55e0b1117fe87d910243</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27922,27923,30998</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22700081$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Marques, Tiago Reis</creatorcontrib><creatorcontrib>Smith, Shubulade</creatorcontrib><creatorcontrib>Bonaccorso, Stefania</creatorcontrib><creatorcontrib>Gaughran, Fiona</creatorcontrib><creatorcontrib>Kolliakou, Anna</creatorcontrib><creatorcontrib>Dazzan, Paola</creatorcontrib><creatorcontrib>Mondelli, Valeria</creatorcontrib><creatorcontrib>Taylor, Heather</creatorcontrib><creatorcontrib>Diforti, Marta</creatorcontrib><creatorcontrib>McGuire, Philip K</creatorcontrib><creatorcontrib>Murray, Robin M</creatorcontrib><creatorcontrib>Howes, Oliver D</creatorcontrib><title>Sexual dysfunction in people with prodromal or first-episode psychosis</title><title>British journal of psychiatry</title><addtitle>Br J Psychiatry</addtitle><description>Sexual dysfunction is common in psychotic disorder but it is not clear whether it is intrinsic to the development of the illness or secondary to other factors.
To compare sexual function in people at ultra-high risk (UHR) of a psychotic disorder, patients with first-episode psychosis predominantly taking antipsychotic drugs and healthy volunteers.
Sexual function was assessed in a UHR group (n = 31), a group with first-episode psychosis (n = 37) and a matched control group of healthy volunteers (n = 56) using the Sexual Function Questionnaire.
There was a significant effect of group on sexual function (P<0.001). Sexual dysfunction was evident in 50% of the UHR group, 65% of first-episode patients and 21% of controls. Within the UHR group, sexual dysfunction was more marked in those who subsequently developed psychosis than in those who did not. Across all groups the severity of sexual dysfunction was correlated with the severity of psychotic symptoms (P<0.001). Within the first-episode group there was no significant difference in sexual dysfunction between patients taking prolactin-raising v. prolactin-sparing antipsychotics.
Sexual dysfunction is present prior to onset of psychosis, suggesting it is intrinsic to the development of illness unlikely to be related to the prolactin-raising properties of antipsychotic medication.</description><subject>Adult</subject><subject>Antipsychotic Agents - adverse effects</subject><subject>Antipsychotic drugs</subject><subject>Case-Control Studies</subject><subject>Female</subject><subject>First time</subject><subject>Humans</subject><subject>Lectures</subject><subject>Male</subject><subject>Property</subject><subject>Psychoses</subject><subject>Psychotic Disorders - complications</subject><subject>Psychotic Disorders - drug therapy</subject><subject>Relatives</subject><subject>Risk Factors</subject><subject>Severity</subject><subject>Sexual dysfunction</subject><subject>Sexual Dysfunction, Physiological - psychology</subject><subject>Sexual Dysfunctions, Psychological - psychology</subject><subject>Surveys and Questionnaires</subject><subject>Volunteers</subject><issn>0007-1250</issn><issn>1472-1465</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>7QJ</sourceid><recordid>eNo9ULFOwzAUtBCIlsIHsKCMLCl-dhInI0IUkCoxAHMU28-qq6Q2diLo32PUwvTupLvTuyPkGugSoGF3cuuX0icMS6DAGD0hcygEy6GoylMyp5SKHFhJZ-Qixm2ivGDinMwYE4nUMCerN_yeuj7T-2imnRqt22V2l3l0vsfsy46bzAengxuSyIXM2BDHHL2NTmPm415tXLTxkpyZro94dbwL8rF6fH94ztevTy8P9-tccSHGHBqOFdUU0UhZidLUrC45clY3DSqtueKdaahkTKEuS6QydRMGa6EboKzgC3J7yE1PfU4Yx3awUWHfdzt0U2whlaqbqgSepHCQquBiDGhaH-zQhX0Stb_ztWm-VvqEoT3Mlzw3x_hJDqj_HX978R82c2zI</recordid><startdate>201208</startdate><enddate>201208</enddate><creator>Marques, Tiago Reis</creator><creator>Smith, Shubulade</creator><creator>Bonaccorso, Stefania</creator><creator>Gaughran, Fiona</creator><creator>Kolliakou, Anna</creator><creator>Dazzan, Paola</creator><creator>Mondelli, Valeria</creator><creator>Taylor, Heather</creator><creator>Diforti, Marta</creator><creator>McGuire, Philip K</creator><creator>Murray, Robin M</creator><creator>Howes, Oliver D</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QJ</scope></search><sort><creationdate>201208</creationdate><title>Sexual dysfunction in people with prodromal or first-episode psychosis</title><author>Marques, Tiago Reis ; Smith, Shubulade ; Bonaccorso, Stefania ; Gaughran, Fiona ; Kolliakou, Anna ; Dazzan, Paola ; Mondelli, Valeria ; Taylor, Heather ; Diforti, Marta ; McGuire, Philip K ; Murray, Robin M ; Howes, Oliver D</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c377t-193e60d0eefbb675f82853e32899ecdd3c3af90b22ced55e0b1117fe87d910243</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Adult</topic><topic>Antipsychotic Agents - adverse effects</topic><topic>Antipsychotic drugs</topic><topic>Case-Control Studies</topic><topic>Female</topic><topic>First time</topic><topic>Humans</topic><topic>Lectures</topic><topic>Male</topic><topic>Property</topic><topic>Psychoses</topic><topic>Psychotic Disorders - complications</topic><topic>Psychotic Disorders - drug therapy</topic><topic>Relatives</topic><topic>Risk Factors</topic><topic>Severity</topic><topic>Sexual dysfunction</topic><topic>Sexual Dysfunction, Physiological - psychology</topic><topic>Sexual Dysfunctions, Psychological - psychology</topic><topic>Surveys and Questionnaires</topic><topic>Volunteers</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Marques, Tiago Reis</creatorcontrib><creatorcontrib>Smith, Shubulade</creatorcontrib><creatorcontrib>Bonaccorso, Stefania</creatorcontrib><creatorcontrib>Gaughran, Fiona</creatorcontrib><creatorcontrib>Kolliakou, Anna</creatorcontrib><creatorcontrib>Dazzan, Paola</creatorcontrib><creatorcontrib>Mondelli, Valeria</creatorcontrib><creatorcontrib>Taylor, Heather</creatorcontrib><creatorcontrib>Diforti, Marta</creatorcontrib><creatorcontrib>McGuire, Philip K</creatorcontrib><creatorcontrib>Murray, Robin M</creatorcontrib><creatorcontrib>Howes, Oliver D</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Applied Social Sciences Index & Abstracts (ASSIA)</collection><jtitle>British journal of psychiatry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Marques, Tiago Reis</au><au>Smith, Shubulade</au><au>Bonaccorso, Stefania</au><au>Gaughran, Fiona</au><au>Kolliakou, Anna</au><au>Dazzan, Paola</au><au>Mondelli, Valeria</au><au>Taylor, Heather</au><au>Diforti, Marta</au><au>McGuire, Philip K</au><au>Murray, Robin M</au><au>Howes, Oliver D</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Sexual dysfunction in people with prodromal or first-episode psychosis</atitle><jtitle>British journal of psychiatry</jtitle><addtitle>Br J Psychiatry</addtitle><date>2012-08</date><risdate>2012</risdate><volume>201</volume><issue>2</issue><spage>131</spage><epage>136</epage><pages>131-136</pages><issn>0007-1250</issn><eissn>1472-1465</eissn><coden>BJPYAJ</coden><abstract>Sexual dysfunction is common in psychotic disorder but it is not clear whether it is intrinsic to the development of the illness or secondary to other factors.
To compare sexual function in people at ultra-high risk (UHR) of a psychotic disorder, patients with first-episode psychosis predominantly taking antipsychotic drugs and healthy volunteers.
Sexual function was assessed in a UHR group (n = 31), a group with first-episode psychosis (n = 37) and a matched control group of healthy volunteers (n = 56) using the Sexual Function Questionnaire.
There was a significant effect of group on sexual function (P<0.001). Sexual dysfunction was evident in 50% of the UHR group, 65% of first-episode patients and 21% of controls. Within the UHR group, sexual dysfunction was more marked in those who subsequently developed psychosis than in those who did not. Across all groups the severity of sexual dysfunction was correlated with the severity of psychotic symptoms (P<0.001). Within the first-episode group there was no significant difference in sexual dysfunction between patients taking prolactin-raising v. prolactin-sparing antipsychotics.
Sexual dysfunction is present prior to onset of psychosis, suggesting it is intrinsic to the development of illness unlikely to be related to the prolactin-raising properties of antipsychotic medication.</abstract><cop>England</cop><pmid>22700081</pmid><doi>10.1192/bjp.bp.111.101220</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| source | Applied Social Sciences Index & Abstracts (ASSIA); MEDLINE; Cambridge Journals - Connect here FIRST to enable access; Alma/SFX Local Collection; EZB Electronic Journals Library |
| subjects | Adult Antipsychotic Agents - adverse effects Antipsychotic drugs Case-Control Studies Female First time Humans Lectures Male Property Psychoses Psychotic Disorders - complications Psychotic Disorders - drug therapy Relatives Risk Factors Severity Sexual dysfunction Sexual Dysfunction, Physiological - psychology Sexual Dysfunctions, Psychological - psychology Surveys and Questionnaires Volunteers |
| title | Sexual dysfunction in people with prodromal or first-episode psychosis |
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