Computed tomography-quantified emphysema distribution is associated with lung function decline
Emphysema distribution is associated with chronic obstructive pulmonary disease. It is, however, unknown whether computed tomography (CT)-quantified emphysema distribution (upper/lower lobe) is associated with lung function decline in heavy (former) smokers. 587 male participants underwent lung CT a...
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| Veröffentlicht in: | The European respiratory journal 2012-10, Vol.40 (4), p.844-850 |
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| creator | MOHAMED HOESEIN, Firdaus A. A RIKXOORT, Eva Van GINNEKEN, Bram Van DE JONG, Pim A PROKOP, Mathias LAMMERS, Jan-Willem J ZANEN, Pieter |
| description | Emphysema distribution is associated with chronic obstructive pulmonary disease. It is, however, unknown whether computed tomography (CT)-quantified emphysema distribution (upper/lower lobe) is associated with lung function decline in heavy (former) smokers. 587 male participants underwent lung CT and pulmonary function testing at baseline and after a median (interquartile range) follow-up of 2.9 (2.8-3.0) yrs. The lungs were automatically segmented based on anatomically defined lung lobes. Severity of emphysema was automatically quantified per anatomical lung lobe and was expressed as the 15th percentile (Hounsfield unit point below which 15% of the low-attenuation voxels are distributed (Perc15)). The CT-quantified emphysema distribution was based on principal component analysis. Linear mixed models were used to assess the association of emphysema distribution with forced expiratory volume in 1 s (FEV(1))/forced vital capacity (FVC), FEV(1) and FVC decline. Mean ± SD age was 60.2 ± 5.4 yrs, mean baseline FEV(1)/FVC was 71.6 ± 9.0% and overall mean Perc15 was -908.5 ± 20.9 HU. Participants with upper lobe-predominant CT-quantified emphysema had a lower FEV(1)/FVC, FEV(1) and FVC after follow-up compared with participants with lower lobe-predominant CT-quantified emphysema (p=0.001), independent of the total extent of CT-quantified emphysema. Heavy (former) smokers with upper lobe-predominant CT-quantified emphysema have a more rapid decrease in lung function than those with lower lobe-predominant CT-quantified emphysema. |
| doi_str_mv | 10.1183/09031936.00186311 |
| format | Article |
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A ; RIKXOORT, Eva Van ; GINNEKEN, Bram Van ; DE JONG, Pim A ; PROKOP, Mathias ; LAMMERS, Jan-Willem J ; ZANEN, Pieter</creator><creatorcontrib>MOHAMED HOESEIN, Firdaus A. A ; RIKXOORT, Eva Van ; GINNEKEN, Bram Van ; DE JONG, Pim A ; PROKOP, Mathias ; LAMMERS, Jan-Willem J ; ZANEN, Pieter</creatorcontrib><description>Emphysema distribution is associated with chronic obstructive pulmonary disease. It is, however, unknown whether computed tomography (CT)-quantified emphysema distribution (upper/lower lobe) is associated with lung function decline in heavy (former) smokers. 587 male participants underwent lung CT and pulmonary function testing at baseline and after a median (interquartile range) follow-up of 2.9 (2.8-3.0) yrs. The lungs were automatically segmented based on anatomically defined lung lobes. Severity of emphysema was automatically quantified per anatomical lung lobe and was expressed as the 15th percentile (Hounsfield unit point below which 15% of the low-attenuation voxels are distributed (Perc15)). The CT-quantified emphysema distribution was based on principal component analysis. Linear mixed models were used to assess the association of emphysema distribution with forced expiratory volume in 1 s (FEV(1))/forced vital capacity (FVC), FEV(1) and FVC decline. Mean ± SD age was 60.2 ± 5.4 yrs, mean baseline FEV(1)/FVC was 71.6 ± 9.0% and overall mean Perc15 was -908.5 ± 20.9 HU. Participants with upper lobe-predominant CT-quantified emphysema had a lower FEV(1)/FVC, FEV(1) and FVC after follow-up compared with participants with lower lobe-predominant CT-quantified emphysema (p=0.001), independent of the total extent of CT-quantified emphysema. Heavy (former) smokers with upper lobe-predominant CT-quantified emphysema have a more rapid decrease in lung function than those with lower lobe-predominant CT-quantified emphysema.</description><identifier>ISSN: 0903-1936</identifier><identifier>EISSN: 1399-3003</identifier><identifier>DOI: 10.1183/09031936.00186311</identifier><identifier>PMID: 22323577</identifier><language>eng</language><publisher>Leeds: Maney</publisher><subject>Aged ; Biological and medical sciences ; Chronic obstructive pulmonary disease, asthma ; Disease Progression ; Humans ; Image Processing, Computer-Assisted ; Longitudinal Studies ; Lung - diagnostic imaging ; Lung - physiopathology ; Male ; Medical sciences ; Middle Aged ; Pneumology ; Pulmonary Disease, Chronic Obstructive - diagnostic imaging ; Pulmonary Disease, Chronic Obstructive - etiology ; Pulmonary Disease, Chronic Obstructive - physiopathology ; Pulmonary Emphysema - diagnostic imaging ; Pulmonary Emphysema - etiology ; Pulmonary Emphysema - physiopathology ; Smoking - adverse effects ; Spirometry ; Tobacco, tobacco smoking ; Tomography, X-Ray Computed ; Toxicology</subject><ispartof>The European respiratory journal, 2012-10, Vol.40 (4), p.844-850</ispartof><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c374t-d51ab0459ee4f7255fe27de4130b97f165c65318da2191b5b4e01ea97b7e31d63</citedby><cites>FETCH-LOGICAL-c374t-d51ab0459ee4f7255fe27de4130b97f165c65318da2191b5b4e01ea97b7e31d63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=26375666$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22323577$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>MOHAMED HOESEIN, Firdaus A. A</creatorcontrib><creatorcontrib>RIKXOORT, Eva Van</creatorcontrib><creatorcontrib>GINNEKEN, Bram Van</creatorcontrib><creatorcontrib>DE JONG, Pim A</creatorcontrib><creatorcontrib>PROKOP, Mathias</creatorcontrib><creatorcontrib>LAMMERS, Jan-Willem J</creatorcontrib><creatorcontrib>ZANEN, Pieter</creatorcontrib><title>Computed tomography-quantified emphysema distribution is associated with lung function decline</title><title>The European respiratory journal</title><addtitle>Eur Respir J</addtitle><description>Emphysema distribution is associated with chronic obstructive pulmonary disease. It is, however, unknown whether computed tomography (CT)-quantified emphysema distribution (upper/lower lobe) is associated with lung function decline in heavy (former) smokers. 587 male participants underwent lung CT and pulmonary function testing at baseline and after a median (interquartile range) follow-up of 2.9 (2.8-3.0) yrs. The lungs were automatically segmented based on anatomically defined lung lobes. Severity of emphysema was automatically quantified per anatomical lung lobe and was expressed as the 15th percentile (Hounsfield unit point below which 15% of the low-attenuation voxels are distributed (Perc15)). The CT-quantified emphysema distribution was based on principal component analysis. Linear mixed models were used to assess the association of emphysema distribution with forced expiratory volume in 1 s (FEV(1))/forced vital capacity (FVC), FEV(1) and FVC decline. Mean ± SD age was 60.2 ± 5.4 yrs, mean baseline FEV(1)/FVC was 71.6 ± 9.0% and overall mean Perc15 was -908.5 ± 20.9 HU. Participants with upper lobe-predominant CT-quantified emphysema had a lower FEV(1)/FVC, FEV(1) and FVC after follow-up compared with participants with lower lobe-predominant CT-quantified emphysema (p=0.001), independent of the total extent of CT-quantified emphysema. Heavy (former) smokers with upper lobe-predominant CT-quantified emphysema have a more rapid decrease in lung function than those with lower lobe-predominant CT-quantified emphysema.</description><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Chronic obstructive pulmonary disease, asthma</subject><subject>Disease Progression</subject><subject>Humans</subject><subject>Image Processing, Computer-Assisted</subject><subject>Longitudinal Studies</subject><subject>Lung - diagnostic imaging</subject><subject>Lung - physiopathology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Pneumology</subject><subject>Pulmonary Disease, Chronic Obstructive - diagnostic imaging</subject><subject>Pulmonary Disease, Chronic Obstructive - etiology</subject><subject>Pulmonary Disease, Chronic Obstructive - physiopathology</subject><subject>Pulmonary Emphysema - diagnostic imaging</subject><subject>Pulmonary Emphysema - etiology</subject><subject>Pulmonary Emphysema - physiopathology</subject><subject>Smoking - adverse effects</subject><subject>Spirometry</subject><subject>Tobacco, tobacco smoking</subject><subject>Tomography, X-Ray Computed</subject><subject>Toxicology</subject><issn>0903-1936</issn><issn>1399-3003</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpF0D1PwzAQBmALgWgp_AAWlAWJJcWXi-1kRBVfUiUWWIkc59Ia5aONY6H-exLawnTS3fPe8DJ2DXwOkOA9TzlCinLOOSQSAU7YFDBNQ-QcT9l0vIcjmLAL574GJWOEczaJIoxQKDVln4u23vieiqBv63bV6c16F269bnpb2mFL9bBwVOugsK7vbO572zaBdYF2rjVWj9Fv26-DyjeroPSN-QUFmco2dMnOSl05ujrMGft4enxfvITLt-fXxcMyNKjiPiwE6JzHIiWKSxUJUVKkCooBeZ6qEqQwUiAkhY4ghVzkMXEgnapcEUIhccbu9n83Xbv15Pqsts5QVemGWu8y4AkkChXgQGFPTdc611GZbTpb6243oGysNTvWmh1rHTI3h_c-r6n4Sxx7HMDtAWhndFV2ujHW_TuJSkgp8QejwYCP</recordid><startdate>20121001</startdate><enddate>20121001</enddate><creator>MOHAMED HOESEIN, Firdaus A. 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A ; RIKXOORT, Eva Van ; GINNEKEN, Bram Van ; DE JONG, Pim A ; PROKOP, Mathias ; LAMMERS, Jan-Willem J ; ZANEN, Pieter</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c374t-d51ab0459ee4f7255fe27de4130b97f165c65318da2191b5b4e01ea97b7e31d63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Chronic obstructive pulmonary disease, asthma</topic><topic>Disease Progression</topic><topic>Humans</topic><topic>Image Processing, Computer-Assisted</topic><topic>Longitudinal Studies</topic><topic>Lung - diagnostic imaging</topic><topic>Lung - physiopathology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Pneumology</topic><topic>Pulmonary Disease, Chronic Obstructive - diagnostic imaging</topic><topic>Pulmonary Disease, Chronic Obstructive - etiology</topic><topic>Pulmonary Disease, Chronic Obstructive - physiopathology</topic><topic>Pulmonary Emphysema - diagnostic imaging</topic><topic>Pulmonary Emphysema - etiology</topic><topic>Pulmonary Emphysema - physiopathology</topic><topic>Smoking - adverse effects</topic><topic>Spirometry</topic><topic>Tobacco, tobacco smoking</topic><topic>Tomography, X-Ray Computed</topic><topic>Toxicology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>MOHAMED HOESEIN, Firdaus A. A</creatorcontrib><creatorcontrib>RIKXOORT, Eva Van</creatorcontrib><creatorcontrib>GINNEKEN, Bram Van</creatorcontrib><creatorcontrib>DE JONG, Pim A</creatorcontrib><creatorcontrib>PROKOP, Mathias</creatorcontrib><creatorcontrib>LAMMERS, Jan-Willem J</creatorcontrib><creatorcontrib>ZANEN, Pieter</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The European respiratory journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>MOHAMED HOESEIN, Firdaus A. A</au><au>RIKXOORT, Eva Van</au><au>GINNEKEN, Bram Van</au><au>DE JONG, Pim A</au><au>PROKOP, Mathias</au><au>LAMMERS, Jan-Willem J</au><au>ZANEN, Pieter</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Computed tomography-quantified emphysema distribution is associated with lung function decline</atitle><jtitle>The European respiratory journal</jtitle><addtitle>Eur Respir J</addtitle><date>2012-10-01</date><risdate>2012</risdate><volume>40</volume><issue>4</issue><spage>844</spage><epage>850</epage><pages>844-850</pages><issn>0903-1936</issn><eissn>1399-3003</eissn><abstract>Emphysema distribution is associated with chronic obstructive pulmonary disease. It is, however, unknown whether computed tomography (CT)-quantified emphysema distribution (upper/lower lobe) is associated with lung function decline in heavy (former) smokers. 587 male participants underwent lung CT and pulmonary function testing at baseline and after a median (interquartile range) follow-up of 2.9 (2.8-3.0) yrs. The lungs were automatically segmented based on anatomically defined lung lobes. Severity of emphysema was automatically quantified per anatomical lung lobe and was expressed as the 15th percentile (Hounsfield unit point below which 15% of the low-attenuation voxels are distributed (Perc15)). The CT-quantified emphysema distribution was based on principal component analysis. Linear mixed models were used to assess the association of emphysema distribution with forced expiratory volume in 1 s (FEV(1))/forced vital capacity (FVC), FEV(1) and FVC decline. Mean ± SD age was 60.2 ± 5.4 yrs, mean baseline FEV(1)/FVC was 71.6 ± 9.0% and overall mean Perc15 was -908.5 ± 20.9 HU. Participants with upper lobe-predominant CT-quantified emphysema had a lower FEV(1)/FVC, FEV(1) and FVC after follow-up compared with participants with lower lobe-predominant CT-quantified emphysema (p=0.001), independent of the total extent of CT-quantified emphysema. Heavy (former) smokers with upper lobe-predominant CT-quantified emphysema have a more rapid decrease in lung function than those with lower lobe-predominant CT-quantified emphysema.</abstract><cop>Leeds</cop><pub>Maney</pub><pmid>22323577</pmid><doi>10.1183/09031936.00186311</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | The European respiratory journal, 2012-10, Vol.40 (4), p.844-850 |
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| subjects | Aged Biological and medical sciences Chronic obstructive pulmonary disease, asthma Disease Progression Humans Image Processing, Computer-Assisted Longitudinal Studies Lung - diagnostic imaging Lung - physiopathology Male Medical sciences Middle Aged Pneumology Pulmonary Disease, Chronic Obstructive - diagnostic imaging Pulmonary Disease, Chronic Obstructive - etiology Pulmonary Disease, Chronic Obstructive - physiopathology Pulmonary Emphysema - diagnostic imaging Pulmonary Emphysema - etiology Pulmonary Emphysema - physiopathology Smoking - adverse effects Spirometry Tobacco, tobacco smoking Tomography, X-Ray Computed Toxicology |
| title | Computed tomography-quantified emphysema distribution is associated with lung function decline |
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