Unconventional protein secretion
It is generally believed that protein secretion or exocytosis is achieved via a conventional ER (endoplasmic reticulum)–Golgi-TGN (trans-Golgi network)–PM (plasma membrane) pathway in the plant endomembrane system. However, such signal peptide (SP)-dependent protein secretion cannot explain the incr...
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| Veröffentlicht in: | Trends in plant science 2012-10, Vol.17 (10), p.606-615 |
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| container_title | Trends in plant science |
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| creator | Ding, Yu Wang, Juan Wang, Junqi Stierhof, York-Dieter Robinson, David G Jiang, Liwen |
| description | It is generally believed that protein secretion or exocytosis is achieved via a conventional ER (endoplasmic reticulum)–Golgi-TGN (trans-Golgi network)–PM (plasma membrane) pathway in the plant endomembrane system. However, such signal peptide (SP)-dependent protein secretion cannot explain the increasing number of SP-lacking proteins which are found outside of the PM in plant cells. The process by which such leaderless secretory proteins (LSPs) gain access to the cell exterior is termed unconventional protein secretion (UPS) and has been well-studied in animal and yeast cells, but largely ignored by the plant community. Here, we review the evidence for UPS in plants especially in regard to the recently discovered EXPO (exocyst-positive-organelle). |
| doi_str_mv | 10.1016/j.tplants.2012.06.004 |
| format | Article |
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However, such signal peptide (SP)-dependent protein secretion cannot explain the increasing number of SP-lacking proteins which are found outside of the PM in plant cells. The process by which such leaderless secretory proteins (LSPs) gain access to the cell exterior is termed unconventional protein secretion (UPS) and has been well-studied in animal and yeast cells, but largely ignored by the plant community. Here, we review the evidence for UPS in plants especially in regard to the recently discovered EXPO (exocyst-positive-organelle).</description><identifier>ISSN: 1360-1385</identifier><identifier>EISSN: 1878-4372</identifier><identifier>DOI: 10.1016/j.tplants.2012.06.004</identifier><identifier>PMID: 22784825</identifier><language>eng</language><publisher>Kidlington: Elsevier Ltd</publisher><subject>Animals ; Biological and medical sciences ; Cell Membrane - metabolism ; cells ; conventional secretion ; endomembrane system ; endoplasmic reticulum ; Endoplasmic Reticulum - metabolism ; exocytosis ; Exosomes - metabolism ; EXPO ; Fundamental and applied biological sciences. Psychology ; Golgi Apparatus - metabolism ; Mammals - metabolism ; Plant Cells - metabolism ; plant communities ; Plant Proteins - metabolism ; Plants - metabolism ; plasma membrane ; protein secretion ; Protein Sorting Signals ; Protein Transport ; proteins ; Secretory Pathway ; signal peptide ; TGN ; unconventional secretion ; Vacuoles - metabolism ; yeasts ; Yeasts - metabolism</subject><ispartof>Trends in plant science, 2012-10, Vol.17 (10), p.606-615</ispartof><rights>2012 Elsevier Ltd</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2012 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c443t-33464ac86960b9cabd3258f3e6b78f0cae88d0cc5868ba0887a1309bd16214ce3</citedby><cites>FETCH-LOGICAL-c443t-33464ac86960b9cabd3258f3e6b78f0cae88d0cc5868ba0887a1309bd16214ce3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S1360138512001306$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=26446706$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22784825$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ding, Yu</creatorcontrib><creatorcontrib>Wang, Juan</creatorcontrib><creatorcontrib>Wang, Junqi</creatorcontrib><creatorcontrib>Stierhof, York-Dieter</creatorcontrib><creatorcontrib>Robinson, David G</creatorcontrib><creatorcontrib>Jiang, Liwen</creatorcontrib><title>Unconventional protein secretion</title><title>Trends in plant science</title><addtitle>Trends Plant Sci</addtitle><description>It is generally believed that protein secretion or exocytosis is achieved via a conventional ER (endoplasmic reticulum)–Golgi-TGN (trans-Golgi network)–PM (plasma membrane) pathway in the plant endomembrane system. However, such signal peptide (SP)-dependent protein secretion cannot explain the increasing number of SP-lacking proteins which are found outside of the PM in plant cells. The process by which such leaderless secretory proteins (LSPs) gain access to the cell exterior is termed unconventional protein secretion (UPS) and has been well-studied in animal and yeast cells, but largely ignored by the plant community. Here, we review the evidence for UPS in plants especially in regard to the recently discovered EXPO (exocyst-positive-organelle).</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Cell Membrane - metabolism</subject><subject>cells</subject><subject>conventional secretion</subject><subject>endomembrane system</subject><subject>endoplasmic reticulum</subject><subject>Endoplasmic Reticulum - metabolism</subject><subject>exocytosis</subject><subject>Exosomes - metabolism</subject><subject>EXPO</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Golgi Apparatus - metabolism</subject><subject>Mammals - metabolism</subject><subject>Plant Cells - metabolism</subject><subject>plant communities</subject><subject>Plant Proteins - metabolism</subject><subject>Plants - metabolism</subject><subject>plasma membrane</subject><subject>protein secretion</subject><subject>Protein Sorting Signals</subject><subject>Protein Transport</subject><subject>proteins</subject><subject>Secretory Pathway</subject><subject>signal peptide</subject><subject>TGN</subject><subject>unconventional secretion</subject><subject>Vacuoles - metabolism</subject><subject>yeasts</subject><subject>Yeasts - metabolism</subject><issn>1360-1385</issn><issn>1878-4372</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1P3DAQhq2KCijlJwB7QeolYfwRZ_aEEKItElIPdM-W40wqr7LJYmeR-PfMahe40ZNH1jMf7yPEmYRSgrRXy3Ja936YcqlAqhJsCWC-iGOJNRZG1-qAa22hkBqrI_Et5yUA1BLtoThSqkaDqjoWs8UQxuGZhimOg-9n6zROFIdZppBo-_ddfO18n-l0_56Ixc-7v7e_i4c_v-5vbx6KYIyeCq2NNT6gnVto5sE3rVYVdppsU2MHwRNiCyFUaLHxgFh7qWHetNIqaQLpE_FjN5cveNpQntwq5kA9Z6Rxk50E5GiSr2a02qEhjTkn6tw6xZVPLwy5rRy3dHs5bivHgXUsh_vO9ys2zYra9643Gwxc7gGfg--75IcQ8wdnjbE1WOYudlznR-f_JWYWj7zJsGG2jZ8TCrSpmbjeEcRSnyMll0OkIVAbE4XJtWP8T5xXFbuWRA</recordid><startdate>20121001</startdate><enddate>20121001</enddate><creator>Ding, Yu</creator><creator>Wang, Juan</creator><creator>Wang, Junqi</creator><creator>Stierhof, York-Dieter</creator><creator>Robinson, David G</creator><creator>Jiang, Liwen</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20121001</creationdate><title>Unconventional protein secretion</title><author>Ding, Yu ; Wang, Juan ; Wang, Junqi ; Stierhof, York-Dieter ; Robinson, David G ; Jiang, Liwen</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c443t-33464ac86960b9cabd3258f3e6b78f0cae88d0cc5868ba0887a1309bd16214ce3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Cell Membrane - metabolism</topic><topic>cells</topic><topic>conventional secretion</topic><topic>endomembrane system</topic><topic>endoplasmic reticulum</topic><topic>Endoplasmic Reticulum - metabolism</topic><topic>exocytosis</topic><topic>Exosomes - metabolism</topic><topic>EXPO</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Golgi Apparatus - metabolism</topic><topic>Mammals - metabolism</topic><topic>Plant Cells - metabolism</topic><topic>plant communities</topic><topic>Plant Proteins - metabolism</topic><topic>Plants - metabolism</topic><topic>plasma membrane</topic><topic>protein secretion</topic><topic>Protein Sorting Signals</topic><topic>Protein Transport</topic><topic>proteins</topic><topic>Secretory Pathway</topic><topic>signal peptide</topic><topic>TGN</topic><topic>unconventional secretion</topic><topic>Vacuoles - metabolism</topic><topic>yeasts</topic><topic>Yeasts - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ding, Yu</creatorcontrib><creatorcontrib>Wang, Juan</creatorcontrib><creatorcontrib>Wang, Junqi</creatorcontrib><creatorcontrib>Stierhof, York-Dieter</creatorcontrib><creatorcontrib>Robinson, David G</creatorcontrib><creatorcontrib>Jiang, Liwen</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Trends in plant science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ding, Yu</au><au>Wang, Juan</au><au>Wang, Junqi</au><au>Stierhof, York-Dieter</au><au>Robinson, David G</au><au>Jiang, Liwen</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Unconventional protein secretion</atitle><jtitle>Trends in plant science</jtitle><addtitle>Trends Plant Sci</addtitle><date>2012-10-01</date><risdate>2012</risdate><volume>17</volume><issue>10</issue><spage>606</spage><epage>615</epage><pages>606-615</pages><issn>1360-1385</issn><eissn>1878-4372</eissn><abstract>It is generally believed that protein secretion or exocytosis is achieved via a conventional ER (endoplasmic reticulum)–Golgi-TGN (trans-Golgi network)–PM (plasma membrane) pathway in the plant endomembrane system. 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| subjects | Animals Biological and medical sciences Cell Membrane - metabolism cells conventional secretion endomembrane system endoplasmic reticulum Endoplasmic Reticulum - metabolism exocytosis Exosomes - metabolism EXPO Fundamental and applied biological sciences. Psychology Golgi Apparatus - metabolism Mammals - metabolism Plant Cells - metabolism plant communities Plant Proteins - metabolism Plants - metabolism plasma membrane protein secretion Protein Sorting Signals Protein Transport proteins Secretory Pathway signal peptide TGN unconventional secretion Vacuoles - metabolism yeasts Yeasts - metabolism |
| title | Unconventional protein secretion |
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