Proteome profiling of tolbutamide-treated rat primary hepatocytes using nano LC-MS/MS and label-free protein quantitation

Tolbutamide is used as a first line oral antihyperglycemic drug for type 2 diabetes. One side effect of this drug, hepatotoxicity, is well recognized; however, the precise mechanisms underlying tolbutamide‐induced hepatotoxicity remain unclear. In this respect, proteomics techniques were used to gai...

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Veröffentlicht in:	Electrophoresis 2012-09, Vol.33 (18), p.2806-2817
Hauptverfasser:	Cho, Young-Eun, Kim, Sang-Hyun, Baek, Moon-Chang
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Blotting, Western Cell Survival - drug effects Chromatography, Liquid - methods Cytochrome P-450 Enzyme System - analysis Cytochrome P-450 Enzyme System - genetics Cytochrome P-450 Enzyme System - metabolism Electrophoresis, Polyacrylamide Gel Hepatocytes - chemistry Hepatocytes - drug effects Hepatocytes - metabolism Hepatotoxicity Linear Models Male Nano UPLC-MS/MS Oxidoreductases - analysis Oxidoreductases - metabolism Protein Interaction Maps - drug effects Proteins - analysis Proteins - chemistry Proteome - analysis Proteome - drug effects Rats Rats, Sprague-Dawley Reproducibility of Results Tandem Mass Spectrometry - methods Tolbutamide Tolbutamide - toxicity Toxicoproteomics
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