Synthesis of cross-linked carboxyl poly(glycerol methacrylate) and its application for the controlled release of doxorubicin

A series of polymers were synthesized by cross-linking carboxyl poly(glycerol methacrylate) (PGOHMA) using hexamethylene diisocyanate (HDI). The structures and molecular weight were characterized by 1H NMR and gel permeation chromatography (GPC). Nanoparticles were then fabricated for encapsulation...

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Veröffentlicht in:	European journal of pharmaceutical sciences 2012-10, Vol.47 (3), p.556-563
Hauptverfasser:	Gu, Wenxing, Ma, Yanan, Zhu, Chuyu, Chen, Baoquan, Ma, Jianbiao, Gao, Hui
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibiotics, Antineoplastic - administration & dosage Antibiotics, Antineoplastic - chemistry Biological and medical sciences Cell Survival - drug effects Cross-linking Cross-Linking Reagents - chemistry Cyanates - chemistry Delayed-Action Preparations - administration & dosage Delayed-Action Preparations - chemistry DOX release Doxorubicin - administration & dosage Doxorubicin - chemistry Drug Carriers - administration & dosage Drug Carriers - chemistry General pharmacology Isocyanates Medical sciences Methacrylates - chemistry Mice Nanoparticles - administration & dosage Nanoparticles - chemistry NIH 3T3 Cells pH-responsive Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Poly(glycerol methacrylate) Polymers - chemistry
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