Biomarkers of deep venous thrombosis
Deep venous thrombosis (DVT), which is associated with pulmonary embolism, is a fatal disease because of its high morbidity and mortality in outpatients and inpatients, especially in hospitalized patients. At the same time, lack of subjective clinical symptoms and objective clinical signs makes the...
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| Veröffentlicht in: | Journal of thrombosis and thrombolysis 2012-10, Vol.34 (3), p.335-346 |
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| container_title | Journal of thrombosis and thrombolysis |
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| creator | Hou, Huacheng Ge, Zhijuan Ying, Pu Dai, Jin Shi, Dongquan Xu, Zhihong Chen, Dongyang Jiang, Qing |
| description | Deep venous thrombosis (DVT), which is associated with pulmonary embolism, is a fatal disease because of its high morbidity and mortality in outpatients and inpatients, especially in hospitalized patients. At the same time, lack of subjective clinical symptoms and objective clinical signs makes the diagnosis complicated. Historically, the primarily imaging modalities, including duplex ultrasound, helical CT scans, and venography, establish the diagnosis of DVT. Currently, both imaging modalities and serology are utilized. These plasma molecules are regarded as the biomarkers of DVT including D-dimer, P-selectin, Factor VIII, thrombin generation, inflammatory cytokines, microparticles, fibrin monomer, leukocyte count and so on. This brief review is used to analyze the contribution of the biomarkers to diagnosis and guidance of therapy for DVT. |
| doi_str_mv | 10.1007/s11239-012-0721-y |
| format | Article |
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At the same time, lack of subjective clinical symptoms and objective clinical signs makes the diagnosis complicated. Historically, the primarily imaging modalities, including duplex ultrasound, helical CT scans, and venography, establish the diagnosis of DVT. Currently, both imaging modalities and serology are utilized. These plasma molecules are regarded as the biomarkers of DVT including D-dimer, P-selectin, Factor VIII, thrombin generation, inflammatory cytokines, microparticles, fibrin monomer, leukocyte count and so on. 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Ge, Zhijuan ; Ying, Pu ; Dai, Jin ; Shi, Dongquan ; Xu, Zhihong ; Chen, Dongyang ; Jiang, Qing</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c372t-d9f62b466db20ab6dbda2bb1ea98b810304ecb9023b3bcfb9337da05895a742d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Animals</topic><topic>Biomarkers - blood</topic><topic>Cardiology</topic><topic>Cell-Derived Microparticles - metabolism</topic><topic>Cytokines - blood</topic><topic>Factor VIII - metabolism</topic><topic>Fibrin Fibrinogen Degradation Products - metabolism</topic><topic>Hematology</topic><topic>Humans</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>P-Selectin - blood</topic><topic>Phlebography</topic><topic>Thrombin - metabolism</topic><topic>Tomography, Spiral Computed</topic><topic>Ultrasonography</topic><topic>Venous Thrombosis - blood</topic><topic>Venous Thrombosis - diagnosis</topic><topic>Venous Thrombosis - diagnostic imaging</topic><topic>Venous Thrombosis - therapy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hou, Huacheng</creatorcontrib><creatorcontrib>Ge, Zhijuan</creatorcontrib><creatorcontrib>Ying, Pu</creatorcontrib><creatorcontrib>Dai, Jin</creatorcontrib><creatorcontrib>Shi, Dongquan</creatorcontrib><creatorcontrib>Xu, Zhihong</creatorcontrib><creatorcontrib>Chen, Dongyang</creatorcontrib><creatorcontrib>Jiang, Qing</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Neurosciences Abstracts</collection><collection>ProQuest - Health & Medical Complete保健、医学与药学数据库</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of thrombosis and thrombolysis</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hou, Huacheng</au><au>Ge, Zhijuan</au><au>Ying, Pu</au><au>Dai, Jin</au><au>Shi, Dongquan</au><au>Xu, Zhihong</au><au>Chen, Dongyang</au><au>Jiang, Qing</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Biomarkers of deep venous thrombosis</atitle><jtitle>Journal of thrombosis and thrombolysis</jtitle><stitle>J Thromb Thrombolysis</stitle><addtitle>J Thromb Thrombolysis</addtitle><date>2012-10-01</date><risdate>2012</risdate><volume>34</volume><issue>3</issue><spage>335</spage><epage>346</epage><pages>335-346</pages><issn>0929-5305</issn><eissn>1573-742X</eissn><abstract>Deep venous thrombosis (DVT), which is associated with pulmonary embolism, is a fatal disease because of its high morbidity and mortality in outpatients and inpatients, especially in hospitalized patients. At the same time, lack of subjective clinical symptoms and objective clinical signs makes the diagnosis complicated. Historically, the primarily imaging modalities, including duplex ultrasound, helical CT scans, and venography, establish the diagnosis of DVT. Currently, both imaging modalities and serology are utilized. These plasma molecules are regarded as the biomarkers of DVT including D-dimer, P-selectin, Factor VIII, thrombin generation, inflammatory cytokines, microparticles, fibrin monomer, leukocyte count and so on. This brief review is used to analyze the contribution of the biomarkers to diagnosis and guidance of therapy for DVT.</abstract><cop>Boston</cop><pub>Springer US</pub><pmid>22528325</pmid><doi>10.1007/s11239-012-0721-y</doi><tpages>12</tpages></addata></record> |
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| subjects | Animals Biomarkers - blood Cardiology Cell-Derived Microparticles - metabolism Cytokines - blood Factor VIII - metabolism Fibrin Fibrinogen Degradation Products - metabolism Hematology Humans Medicine Medicine & Public Health P-Selectin - blood Phlebography Thrombin - metabolism Tomography, Spiral Computed Ultrasonography Venous Thrombosis - blood Venous Thrombosis - diagnosis Venous Thrombosis - diagnostic imaging Venous Thrombosis - therapy |
| title | Biomarkers of deep venous thrombosis |
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