Genetics of type 2 diabetes mellitus and other specific types of diabetes; its role in treatment modalities

Highlights ► Type 2 diabetes is a polygenic disorder involving at least 40 genes. ► It results from complex interaction between multiple genes and environmental factors. ► Polymorphism in certain genes is associated with susceptibility for diabetes. ► Mutational screening for candidate genes could s...

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Veröffentlicht in:	Diabetes & metabolic syndrome clinical research & reviews 2012, Vol.6 (1), p.54-58
Hauptverfasser:	Kota, Sunil K, Meher, Lalit K, Jammula, Sruti, Kota, Siva K, Modi, Kirtikumar D
Format:	Artikel
Sprache:	eng
Schlagworte:	ATP-Binding Cassette Transporters - genetics Diabetes Mellitus, Type 2 - drug therapy Diabetes Mellitus, Type 2 - genetics Diabetes Mellitus, Type 2 - physiopathology Endocrinology & Metabolism Gene-Environment Interaction Genetic Predisposition to Disease Genetics Humans Hypoglycemic Agents - therapeutic use Insulin Insulin Resistance - genetics Metformin - therapeutic use MODY Multifactorial Inheritance - genetics Mutation Peroxisome proliferator-activated receptor-γ gene Pharmacogenetics Polymorphism, Genetic Potassium Channels, Inwardly Rectifying - genetics PPAR gamma - genetics Receptors, Drug - genetics Sulfonylurea Compounds - therapeutic use Sulfonylurea Receptors Transcription Factor 7-Like 2 Protein - genetics Treatment Outcome Type 2 diabetes mellitus
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Zusammenfassung:	Highlights ► Type 2 diabetes is a polygenic disorder involving at least 40 genes. ► It results from complex interaction between multiple genes and environmental factors. ► Polymorphism in certain genes is associated with susceptibility for diabetes. ► Mutational screening for candidate genes could serve as a preventive measure.
ISSN:	1871-4021 1878-0334
DOI:	10.1016/j.dsx.2012.05.014