Relationship of transcription factor 7 like 2 gene rs7903146 variation with type 2 diabetes and obesity related parameters
Abstract Aims The allele frequencies of transcription factor 7 like 2 (TCF7L2) gene rs7903146 polymorphism in type 2 diabetes mellitus (T2DM) and non-T2DM controls were determined. Methods TCF7L2 rs7903146 genotypes were determined with qPCR. Results The TCF7L2 gene rs7903146 genotype frequencies fo...
Gespeichert in:
| Veröffentlicht in: | Diabetes & metabolic syndrome clinical research & reviews 2012, Vol.6 (1), p.48-53 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 53 |
|---|---|
| container_issue | 1 |
| container_start_page | 48 |
| container_title | Diabetes & metabolic syndrome clinical research & reviews |
| container_volume | 6 |
| creator | Kahveci, Cigdem Koldemir, Meliha Cagatay, Penbe Bayer, Hikmet Yildiz, Sema Bagriacik, Nazif Duman, Belgin Susleyici |
| description | Abstract Aims The allele frequencies of transcription factor 7 like 2 (TCF7L2) gene rs7903146 polymorphism in type 2 diabetes mellitus (T2DM) and non-T2DM controls were determined. Methods TCF7L2 rs7903146 genotypes were determined with qPCR. Results The TCF7L2 gene rs7903146 genotype frequencies for homozygous wild type (C/C), heterozygous (C/T) and homozygous polymorphic (T/T) for T2DM patients were determined, respectively, as 71.4%, 14.3%, 14.3% and 72.5%, 11.8%, 15.7% for controls. The weight, length and lean body mass were higher in C/T + T/T compared to C/C carriers. Glucose, insulin, insulin resistance and homeostatic model assessment (HOMA) were nonsignificantly higher in rs7903146C/T + T/T in comparison to C/C. TCF7L2 gene rs7903146 genotypes were not found to interact with drugs. The absence of any difference between genotype frequencies among study groups indicates that no association persists with TCF7L2 gene rs7903146 polymorphism and T2DM. Conclusions The effects of rs7903146 variation over some obesity variables suggest that this variation may effect T2DM development via obesity. |
| doi_str_mv | 10.1016/j.dsx.2012.05.002 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1081431606</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S1871402112000641</els_id><sourcerecordid>1081431606</sourcerecordid><originalsourceid>FETCH-LOGICAL-c408t-e12271db8357ef0de6105726c3d47272b78f3e3a5aa395fcbfdadbdf2201f5103</originalsourceid><addsrcrecordid>eNp9kU2P1SAUhhujcT70B7gxLN20ngOl7Y2JiZnoaDKJiR9rQuHgcKe3VOCOXn-9dO7owoUrCDzvS3hOVT1DaBCwe7ltbPrZcEDegGwA-IPqFId-qEGI9uHdHusWOJ5UZyltAaTc8M3j6oQLwJZLeVr9-kSTzj7M6dovLDiWo56TiX5ZD5nTJofIejb5G2KcfaOZWEz9BgS2HbvV0d-l2Q-fr1k-LCtkvR4pU2J6tiyMlHw-sLi-Q5YtOupduY3pSfXI6SnR0_v1vPr67u2Xi_f11cfLDxdvrmrTwpBrQs57tOMgZE8OLHUIsuedEbbtec_HfnCChJZai410ZnRW29E6Xrw4iSDOqxfH3iWG73tKWe18MjRNeqawTwphwFZgB11B8YiaGFKK5NQS_U7HQ4HUqlxtVVGuVuUKpCrKS-b5ff1-3JH9m_jjuACvjgCVT956iioZT7Mh6yOZrGzw_61__U_aTH72Rk83dKC0Dfs4F3sKVSoZ9Xmd-Tpy5ADQtSh-A0BrpnU</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1081431606</pqid></control><display><type>article</type><title>Relationship of transcription factor 7 like 2 gene rs7903146 variation with type 2 diabetes and obesity related parameters</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Kahveci, Cigdem ; Koldemir, Meliha ; Cagatay, Penbe ; Bayer, Hikmet ; Yildiz, Sema ; Bagriacik, Nazif ; Duman, Belgin Susleyici</creator><creatorcontrib>Kahveci, Cigdem ; Koldemir, Meliha ; Cagatay, Penbe ; Bayer, Hikmet ; Yildiz, Sema ; Bagriacik, Nazif ; Duman, Belgin Susleyici</creatorcontrib><description>Abstract Aims The allele frequencies of transcription factor 7 like 2 (TCF7L2) gene rs7903146 polymorphism in type 2 diabetes mellitus (T2DM) and non-T2DM controls were determined. Methods TCF7L2 rs7903146 genotypes were determined with qPCR. Results The TCF7L2 gene rs7903146 genotype frequencies for homozygous wild type (C/C), heterozygous (C/T) and homozygous polymorphic (T/T) for T2DM patients were determined, respectively, as 71.4%, 14.3%, 14.3% and 72.5%, 11.8%, 15.7% for controls. The weight, length and lean body mass were higher in C/T + T/T compared to C/C carriers. Glucose, insulin, insulin resistance and homeostatic model assessment (HOMA) were nonsignificantly higher in rs7903146C/T + T/T in comparison to C/C. TCF7L2 gene rs7903146 genotypes were not found to interact with drugs. The absence of any difference between genotype frequencies among study groups indicates that no association persists with TCF7L2 gene rs7903146 polymorphism and T2DM. Conclusions The effects of rs7903146 variation over some obesity variables suggest that this variation may effect T2DM development via obesity.</description><identifier>ISSN: 1871-4021</identifier><identifier>EISSN: 1878-0334</identifier><identifier>DOI: 10.1016/j.dsx.2012.05.002</identifier><identifier>PMID: 23014255</identifier><language>eng</language><publisher>Netherlands: Elsevier Ltd</publisher><subject>Blood Glucose - metabolism ; Body Weights and Measures ; Comorbidity ; Diabetes Mellitus, Type 2 - diagnosis ; Diabetes Mellitus, Type 2 - epidemiology ; Diabetes Mellitus, Type 2 - genetics ; DNA Mutational Analysis ; Endocrinology & Metabolism ; Fat mass ; Female ; Gene Frequency ; Genetic Predisposition to Disease ; Genotype ; Humans ; Insulin - blood ; Insulin resistance ; Insulin Resistance - genetics ; Male ; Middle Aged ; Obesity ; Obesity - diagnosis ; Obesity - epidemiology ; Obesity - genetics ; Polymorphism, Single Nucleotide ; rs7903146 polymorphism ; Serum lipids ; TCF7L2 ; Transcription Factor 7-Like 2 Protein - genetics</subject><ispartof>Diabetes & metabolic syndrome clinical research & reviews, 2012, Vol.6 (1), p.48-53</ispartof><rights>Diabetes India</rights><rights>2012 Diabetes India</rights><rights>Copyright © 2012 Diabetes India. Published by Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c408t-e12271db8357ef0de6105726c3d47272b78f3e3a5aa395fcbfdadbdf2201f5103</citedby><cites>FETCH-LOGICAL-c408t-e12271db8357ef0de6105726c3d47272b78f3e3a5aa395fcbfdadbdf2201f5103</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.dsx.2012.05.002$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,777,781,3537,4010,27904,27905,27906,45976</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23014255$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kahveci, Cigdem</creatorcontrib><creatorcontrib>Koldemir, Meliha</creatorcontrib><creatorcontrib>Cagatay, Penbe</creatorcontrib><creatorcontrib>Bayer, Hikmet</creatorcontrib><creatorcontrib>Yildiz, Sema</creatorcontrib><creatorcontrib>Bagriacik, Nazif</creatorcontrib><creatorcontrib>Duman, Belgin Susleyici</creatorcontrib><title>Relationship of transcription factor 7 like 2 gene rs7903146 variation with type 2 diabetes and obesity related parameters</title><title>Diabetes & metabolic syndrome clinical research & reviews</title><addtitle>Diabetes Metab Syndr</addtitle><description>Abstract Aims The allele frequencies of transcription factor 7 like 2 (TCF7L2) gene rs7903146 polymorphism in type 2 diabetes mellitus (T2DM) and non-T2DM controls were determined. Methods TCF7L2 rs7903146 genotypes were determined with qPCR. Results The TCF7L2 gene rs7903146 genotype frequencies for homozygous wild type (C/C), heterozygous (C/T) and homozygous polymorphic (T/T) for T2DM patients were determined, respectively, as 71.4%, 14.3%, 14.3% and 72.5%, 11.8%, 15.7% for controls. The weight, length and lean body mass were higher in C/T + T/T compared to C/C carriers. Glucose, insulin, insulin resistance and homeostatic model assessment (HOMA) were nonsignificantly higher in rs7903146C/T + T/T in comparison to C/C. TCF7L2 gene rs7903146 genotypes were not found to interact with drugs. The absence of any difference between genotype frequencies among study groups indicates that no association persists with TCF7L2 gene rs7903146 polymorphism and T2DM. Conclusions The effects of rs7903146 variation over some obesity variables suggest that this variation may effect T2DM development via obesity.</description><subject>Blood Glucose - metabolism</subject><subject>Body Weights and Measures</subject><subject>Comorbidity</subject><subject>Diabetes Mellitus, Type 2 - diagnosis</subject><subject>Diabetes Mellitus, Type 2 - epidemiology</subject><subject>Diabetes Mellitus, Type 2 - genetics</subject><subject>DNA Mutational Analysis</subject><subject>Endocrinology & Metabolism</subject><subject>Fat mass</subject><subject>Female</subject><subject>Gene Frequency</subject><subject>Genetic Predisposition to Disease</subject><subject>Genotype</subject><subject>Humans</subject><subject>Insulin - blood</subject><subject>Insulin resistance</subject><subject>Insulin Resistance - genetics</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Obesity</subject><subject>Obesity - diagnosis</subject><subject>Obesity - epidemiology</subject><subject>Obesity - genetics</subject><subject>Polymorphism, Single Nucleotide</subject><subject>rs7903146 polymorphism</subject><subject>Serum lipids</subject><subject>TCF7L2</subject><subject>Transcription Factor 7-Like 2 Protein - genetics</subject><issn>1871-4021</issn><issn>1878-0334</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kU2P1SAUhhujcT70B7gxLN20ngOl7Y2JiZnoaDKJiR9rQuHgcKe3VOCOXn-9dO7owoUrCDzvS3hOVT1DaBCwe7ltbPrZcEDegGwA-IPqFId-qEGI9uHdHusWOJ5UZyltAaTc8M3j6oQLwJZLeVr9-kSTzj7M6dovLDiWo56TiX5ZD5nTJofIejb5G2KcfaOZWEz9BgS2HbvV0d-l2Q-fr1k-LCtkvR4pU2J6tiyMlHw-sLi-Q5YtOupduY3pSfXI6SnR0_v1vPr67u2Xi_f11cfLDxdvrmrTwpBrQs57tOMgZE8OLHUIsuedEbbtec_HfnCChJZai410ZnRW29E6Xrw4iSDOqxfH3iWG73tKWe18MjRNeqawTwphwFZgB11B8YiaGFKK5NQS_U7HQ4HUqlxtVVGuVuUKpCrKS-b5ff1-3JH9m_jjuACvjgCVT956iioZT7Mh6yOZrGzw_61__U_aTH72Rk83dKC0Dfs4F3sKVSoZ9Xmd-Tpy5ADQtSh-A0BrpnU</recordid><startdate>2012</startdate><enddate>2012</enddate><creator>Kahveci, Cigdem</creator><creator>Koldemir, Meliha</creator><creator>Cagatay, Penbe</creator><creator>Bayer, Hikmet</creator><creator>Yildiz, Sema</creator><creator>Bagriacik, Nazif</creator><creator>Duman, Belgin Susleyici</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>2012</creationdate><title>Relationship of transcription factor 7 like 2 gene rs7903146 variation with type 2 diabetes and obesity related parameters</title><author>Kahveci, Cigdem ; Koldemir, Meliha ; Cagatay, Penbe ; Bayer, Hikmet ; Yildiz, Sema ; Bagriacik, Nazif ; Duman, Belgin Susleyici</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c408t-e12271db8357ef0de6105726c3d47272b78f3e3a5aa395fcbfdadbdf2201f5103</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Blood Glucose - metabolism</topic><topic>Body Weights and Measures</topic><topic>Comorbidity</topic><topic>Diabetes Mellitus, Type 2 - diagnosis</topic><topic>Diabetes Mellitus, Type 2 - epidemiology</topic><topic>Diabetes Mellitus, Type 2 - genetics</topic><topic>DNA Mutational Analysis</topic><topic>Endocrinology & Metabolism</topic><topic>Fat mass</topic><topic>Female</topic><topic>Gene Frequency</topic><topic>Genetic Predisposition to Disease</topic><topic>Genotype</topic><topic>Humans</topic><topic>Insulin - blood</topic><topic>Insulin resistance</topic><topic>Insulin Resistance - genetics</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Obesity</topic><topic>Obesity - diagnosis</topic><topic>Obesity - epidemiology</topic><topic>Obesity - genetics</topic><topic>Polymorphism, Single Nucleotide</topic><topic>rs7903146 polymorphism</topic><topic>Serum lipids</topic><topic>TCF7L2</topic><topic>Transcription Factor 7-Like 2 Protein - genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kahveci, Cigdem</creatorcontrib><creatorcontrib>Koldemir, Meliha</creatorcontrib><creatorcontrib>Cagatay, Penbe</creatorcontrib><creatorcontrib>Bayer, Hikmet</creatorcontrib><creatorcontrib>Yildiz, Sema</creatorcontrib><creatorcontrib>Bagriacik, Nazif</creatorcontrib><creatorcontrib>Duman, Belgin Susleyici</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Diabetes & metabolic syndrome clinical research & reviews</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kahveci, Cigdem</au><au>Koldemir, Meliha</au><au>Cagatay, Penbe</au><au>Bayer, Hikmet</au><au>Yildiz, Sema</au><au>Bagriacik, Nazif</au><au>Duman, Belgin Susleyici</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Relationship of transcription factor 7 like 2 gene rs7903146 variation with type 2 diabetes and obesity related parameters</atitle><jtitle>Diabetes & metabolic syndrome clinical research & reviews</jtitle><addtitle>Diabetes Metab Syndr</addtitle><date>2012</date><risdate>2012</risdate><volume>6</volume><issue>1</issue><spage>48</spage><epage>53</epage><pages>48-53</pages><issn>1871-4021</issn><eissn>1878-0334</eissn><abstract>Abstract Aims The allele frequencies of transcription factor 7 like 2 (TCF7L2) gene rs7903146 polymorphism in type 2 diabetes mellitus (T2DM) and non-T2DM controls were determined. Methods TCF7L2 rs7903146 genotypes were determined with qPCR. Results The TCF7L2 gene rs7903146 genotype frequencies for homozygous wild type (C/C), heterozygous (C/T) and homozygous polymorphic (T/T) for T2DM patients were determined, respectively, as 71.4%, 14.3%, 14.3% and 72.5%, 11.8%, 15.7% for controls. The weight, length and lean body mass were higher in C/T + T/T compared to C/C carriers. Glucose, insulin, insulin resistance and homeostatic model assessment (HOMA) were nonsignificantly higher in rs7903146C/T + T/T in comparison to C/C. TCF7L2 gene rs7903146 genotypes were not found to interact with drugs. The absence of any difference between genotype frequencies among study groups indicates that no association persists with TCF7L2 gene rs7903146 polymorphism and T2DM. Conclusions The effects of rs7903146 variation over some obesity variables suggest that this variation may effect T2DM development via obesity.</abstract><cop>Netherlands</cop><pub>Elsevier Ltd</pub><pmid>23014255</pmid><doi>10.1016/j.dsx.2012.05.002</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1871-4021 |
| ispartof | Diabetes & metabolic syndrome clinical research & reviews, 2012, Vol.6 (1), p.48-53 |
| issn | 1871-4021 1878-0334 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1081431606 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Blood Glucose - metabolism Body Weights and Measures Comorbidity Diabetes Mellitus, Type 2 - diagnosis Diabetes Mellitus, Type 2 - epidemiology Diabetes Mellitus, Type 2 - genetics DNA Mutational Analysis Endocrinology & Metabolism Fat mass Female Gene Frequency Genetic Predisposition to Disease Genotype Humans Insulin - blood Insulin resistance Insulin Resistance - genetics Male Middle Aged Obesity Obesity - diagnosis Obesity - epidemiology Obesity - genetics Polymorphism, Single Nucleotide rs7903146 polymorphism Serum lipids TCF7L2 Transcription Factor 7-Like 2 Protein - genetics |
| title | Relationship of transcription factor 7 like 2 gene rs7903146 variation with type 2 diabetes and obesity related parameters |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-18T09%3A42%3A35IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Relationship%20of%20transcription%20factor%207%20like%202%20gene%20rs7903146%20variation%20with%20type%202%20diabetes%20and%20obesity%20related%20parameters&rft.jtitle=Diabetes%20&%20metabolic%20syndrome%20clinical%20research%20&%20reviews&rft.au=Kahveci,%20Cigdem&rft.date=2012&rft.volume=6&rft.issue=1&rft.spage=48&rft.epage=53&rft.pages=48-53&rft.issn=1871-4021&rft.eissn=1878-0334&rft_id=info:doi/10.1016/j.dsx.2012.05.002&rft_dat=%3Cproquest_cross%3E1081431606%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1081431606&rft_id=info:pmid/23014255&rft_els_id=S1871402112000641&rfr_iscdi=true |