Decaffeinated green tea extract improves hypertension and insulin resistance in a rat model of metabolic syndrome

Abstract Background Oxidative stress and endothelial dysfunction are closely associated with hypertension and insulin resistance (IR) in metabolic syndrome (MetS). It is still controversial whether green tea extract (GTE) may have blood pressure (BP) lowering effect. Decaffeinated GTE might be presu...

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Veröffentlicht in:	Atherosclerosis 2012-10, Vol.224 (2), p.377-383
Hauptverfasser:	Ihm, Sang-Hyun, Jang, Sung-Won, Kim, Ok-Ran, Chang, Kiyuk, Oak, Min-Ho, Lee, Jung-Ok, Lim, Dong-Yoon, Kim, Jae-Hyung
Format:	Artikel
Sprache:	eng
Schlagworte:	animal models Animals Antihypertensive Agents - chemistry Antihypertensive Agents - pharmacology antioxidant activity Antioxidants - chemistry Antioxidants - pharmacology aorta Aorta, Thoracic - drug effects Aorta, Thoracic - metabolism Aorta, Thoracic - physiopathology atherosclerosis Atherosclerosis (general aspects, experimental research) Biological and medical sciences Blood and lymphatic vessels Blood Glucose - drug effects Blood Glucose - metabolism blood pressure Blood Pressure - drug effects Caffeine Caffeine - analysis Camellia sinensis Cardiology. Vascular system Cardiovascular Disease Models, Animal Dose-Response Relationship, Drug Endocrinopathies Endothelial function endothelial nitric oxide synthase endothelium fasting flavanols glucose glucose tolerance tests green tea Green tea extract Hypertension Hypertension - blood Hypertension - drug therapy Hypertension - physiopathology Hypoglycemic Agents - chemistry Hypoglycemic Agents - pharmacology immunoblotting immunohistochemistry insulin Insulin - blood Insulin Resistance Male Medical sciences metabolic syndrome Metabolic Syndrome - blood Metabolic Syndrome - drug therapy Metabolic Syndrome - physiopathology NADP (coenzyme) NADPH Oxidases - metabolism Nitric Oxide Synthase Type III - metabolism Non tumoral diseases. Target tissue resistance. Benign neoplasms oxidative stress Oxidative Stress - drug effects Phosphorylation Plant Extracts - chemistry Plant Extracts - pharmacology Proto-Oncogene Proteins c-akt - metabolism Rats Rats, Inbred OLETF reactive oxygen species Reactive Oxygen Species - metabolism Thyroid. Thyroid axis (diseases) Time Factors Vasodilation - drug effects Vasodilator Agents - pharmacology
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