Effect of Added Calcium, Phosphorus, and Infant Formula on Calcium and Phosphorus Dialyzability in Preterm Donor Human Milk
ABSTRACT Objectives: We studied the effect of preparing donor human milk (DHM) with commonly used nutritional additives on the dialyzability of calcium and phosphate. We hypothesized that the additives to DHM would decrease the dialyzability of calcium and phosphate when prepared according to hospit...
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| Veröffentlicht in: | Journal of pediatric gastroenterology and nutrition 2012-10, Vol.55 (4), p.390-397 |
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| container_title | Journal of pediatric gastroenterology and nutrition |
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| creator | Fogleman, April D. Cohen, Ronald S. Sakamoto, Pauline Allen, Jonathan C. |
| description | ABSTRACT
Objectives:
We studied the effect of preparing donor human milk (DHM) with commonly used nutritional additives on the dialyzability of calcium and phosphate. We hypothesized that the additives to DHM would decrease the dialyzability of calcium and phosphate when prepared according to hospital protocols.
Methods:
An in vitro system simulating premature infant digestion was developed to measure dialyzability of calcium and phosphate in DHM. Dialyzable calcium and phosphate were measured after in vitro digestion in DHM before and after preparation of DHM with the following additives according to hospital protocols: calcium glubionate, sodium potassium phosphate, calcium glubionate and sodium potassium phosphate added together, Similac human milk fortifier, Similac NeoSure, or Enfamil Enfacare.
Results:
The percentage of dialyzable calcium in DHM with added calcium and calcium and phosphate together was greater than the percentage of dialyzable calcium in DHM with added powdered infant formulas (P < 0.0001). Dialyzable calcium was greater in DHM with added calcium and with added calcium and phosphate than in all other treatment groups (P < 0.0001). Dialyzable calcium in DHM without additives was not different from dialyzable calcium in DHM with added phosphate or with added powdered infant formulas. Dialyzable phosphate did not differ between the treatment groups.
Conclusions:
The addition of calcium alone or calcium and phosphate together increased calcium dialyzability in DHM significantly, whereas the addition of powdered human milk fortifier or formulas did not. The addition of calcium or calcium with phosphate together to DHM may provide the most dialyzable calcium. |
| doi_str_mv | 10.1097/MPG.0b013e318254ec07 |
| format | Article |
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Objectives:
We studied the effect of preparing donor human milk (DHM) with commonly used nutritional additives on the dialyzability of calcium and phosphate. We hypothesized that the additives to DHM would decrease the dialyzability of calcium and phosphate when prepared according to hospital protocols.
Methods:
An in vitro system simulating premature infant digestion was developed to measure dialyzability of calcium and phosphate in DHM. Dialyzable calcium and phosphate were measured after in vitro digestion in DHM before and after preparation of DHM with the following additives according to hospital protocols: calcium glubionate, sodium potassium phosphate, calcium glubionate and sodium potassium phosphate added together, Similac human milk fortifier, Similac NeoSure, or Enfamil Enfacare.
Results:
The percentage of dialyzable calcium in DHM with added calcium and calcium and phosphate together was greater than the percentage of dialyzable calcium in DHM with added powdered infant formulas (P < 0.0001). Dialyzable calcium was greater in DHM with added calcium and with added calcium and phosphate than in all other treatment groups (P < 0.0001). Dialyzable calcium in DHM without additives was not different from dialyzable calcium in DHM with added phosphate or with added powdered infant formulas. Dialyzable phosphate did not differ between the treatment groups.
Conclusions:
The addition of calcium alone or calcium and phosphate together increased calcium dialyzability in DHM significantly, whereas the addition of powdered human milk fortifier or formulas did not. The addition of calcium or calcium with phosphate together to DHM may provide the most dialyzable calcium.</description><identifier>ISSN: 0277-2116</identifier><identifier>EISSN: 1536-4801</identifier><identifier>DOI: 10.1097/MPG.0b013e318254ec07</identifier><identifier>PMID: 22437472</identifier><identifier>CODEN: JPGND6</identifier><language>eng</language><publisher>Hagerstown, MD: Copyright by ESPGHAN and NASPGHAN</publisher><subject>Biological and medical sciences ; calcium ; Calcium, Dietary - metabolism ; dialyzability ; Diseases of mother, fetus and pregnancy ; donor human milk ; Feeding. Feeding behavior ; Food, Fortified ; fortification ; Fundamental and applied biological sciences. Psychology ; Gynecology. Andrology. Obstetrics ; Humans ; Infant Formula ; Infant, Newborn ; Infant, Premature ; Medical sciences ; Milk, Human ; phosphate ; Phosphates - metabolism ; Phosphorus, Dietary - metabolism ; Pregnancy. Fetus. Placenta ; Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><ispartof>Journal of pediatric gastroenterology and nutrition, 2012-10, Vol.55 (4), p.390-397</ispartof><rights>2012 by European Society for European Society for Pediatric Gastroenterology, Hepatology, and Nutrition and North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition</rights><rights>Copyright 2012 by ESPGHAN and NASPGHAN</rights><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4867-8f35ede8df779d3e40490ff81ec9e5d69377f2903a04043c37c5eeb3feb3d6c63</citedby><cites>FETCH-LOGICAL-c4867-8f35ede8df779d3e40490ff81ec9e5d69377f2903a04043c37c5eeb3feb3d6c63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1097%2FMPG.0b013e318254ec07$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1097%2FMPG.0b013e318254ec07$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=26419070$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22437472$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fogleman, April D.</creatorcontrib><creatorcontrib>Cohen, Ronald S.</creatorcontrib><creatorcontrib>Sakamoto, Pauline</creatorcontrib><creatorcontrib>Allen, Jonathan C.</creatorcontrib><title>Effect of Added Calcium, Phosphorus, and Infant Formula on Calcium and Phosphorus Dialyzability in Preterm Donor Human Milk</title><title>Journal of pediatric gastroenterology and nutrition</title><addtitle>J Pediatr Gastroenterol Nutr</addtitle><description>ABSTRACT
Objectives:
We studied the effect of preparing donor human milk (DHM) with commonly used nutritional additives on the dialyzability of calcium and phosphate. We hypothesized that the additives to DHM would decrease the dialyzability of calcium and phosphate when prepared according to hospital protocols.
Methods:
An in vitro system simulating premature infant digestion was developed to measure dialyzability of calcium and phosphate in DHM. Dialyzable calcium and phosphate were measured after in vitro digestion in DHM before and after preparation of DHM with the following additives according to hospital protocols: calcium glubionate, sodium potassium phosphate, calcium glubionate and sodium potassium phosphate added together, Similac human milk fortifier, Similac NeoSure, or Enfamil Enfacare.
Results:
The percentage of dialyzable calcium in DHM with added calcium and calcium and phosphate together was greater than the percentage of dialyzable calcium in DHM with added powdered infant formulas (P < 0.0001). Dialyzable calcium was greater in DHM with added calcium and with added calcium and phosphate than in all other treatment groups (P < 0.0001). Dialyzable calcium in DHM without additives was not different from dialyzable calcium in DHM with added phosphate or with added powdered infant formulas. Dialyzable phosphate did not differ between the treatment groups.
Conclusions:
The addition of calcium alone or calcium and phosphate together increased calcium dialyzability in DHM significantly, whereas the addition of powdered human milk fortifier or formulas did not. The addition of calcium or calcium with phosphate together to DHM may provide the most dialyzable calcium.</description><subject>Biological and medical sciences</subject><subject>calcium</subject><subject>Calcium, Dietary - metabolism</subject><subject>dialyzability</subject><subject>Diseases of mother, fetus and pregnancy</subject><subject>donor human milk</subject><subject>Feeding. Feeding behavior</subject><subject>Food, Fortified</subject><subject>fortification</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>Infant Formula</subject><subject>Infant, Newborn</subject><subject>Infant, Premature</subject><subject>Medical sciences</subject><subject>Milk, Human</subject><subject>phosphate</subject><subject>Phosphates - metabolism</subject><subject>Phosphorus, Dietary - metabolism</subject><subject>Pregnancy. Fetus. Placenta</subject><subject>Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><issn>0277-2116</issn><issn>1536-4801</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkMFu1DAQhi0EokvhDRDyBYlDU8axEzsHDmXbbYta2AOcI6891po68dZOVC28PCm7pRIXOFhzmO8f__oIec3gmEEj318vz49hBYwjZ6qsBBqQT8iMVbwuhAL2lMyglLIoGasPyIucvwOAFBU8JwdlKbgUspyRn2fOoRlodPTEWrR0roPxY3dEl-uYN-uYxnxEdW_pZe90P9BFTN0YNI39A_p7-0jTU6_D9ode-eCHLfU9XSYcMHX0NPYx0Yux0z299uHmJXnmdMj4aj8PybfF2df5RXH15fxyfnJVGKFqWSjHK7SorJOysRwFiAacUwxNg5WtGy6lKxvgGqYVN1yaCnHF3fRsbWp-SN7t7m5SvB0xD23ns8EQdI9xzC0DBUrxWt6jYoeaFHNO6NpN8p1O2wlq77W3k_b2b-1T7M3-h3HVof0TevA8AW_3gM5GB5d0b3x-5GrBGpAwcWrH3cUwOcs3YbzD1K5Rh2H9rw4f9lEfcPtfvdtPy8_84wLqqSb_BUpFsIE</recordid><startdate>201210</startdate><enddate>201210</enddate><creator>Fogleman, April D.</creator><creator>Cohen, Ronald S.</creator><creator>Sakamoto, Pauline</creator><creator>Allen, Jonathan C.</creator><general>Copyright by ESPGHAN and NASPGHAN</general><general>Lippincott Williams & Wilkins</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201210</creationdate><title>Effect of Added Calcium, Phosphorus, and Infant Formula on Calcium and Phosphorus Dialyzability in Preterm Donor Human Milk</title><author>Fogleman, April D. ; Cohen, Ronald S. ; Sakamoto, Pauline ; Allen, Jonathan C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4867-8f35ede8df779d3e40490ff81ec9e5d69377f2903a04043c37c5eeb3feb3d6c63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Biological and medical sciences</topic><topic>calcium</topic><topic>Calcium, Dietary - metabolism</topic><topic>dialyzability</topic><topic>Diseases of mother, fetus and pregnancy</topic><topic>donor human milk</topic><topic>Feeding. Feeding behavior</topic><topic>Food, Fortified</topic><topic>fortification</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Humans</topic><topic>Infant Formula</topic><topic>Infant, Newborn</topic><topic>Infant, Premature</topic><topic>Medical sciences</topic><topic>Milk, Human</topic><topic>phosphate</topic><topic>Phosphates - metabolism</topic><topic>Phosphorus, Dietary - metabolism</topic><topic>Pregnancy. Fetus. Placenta</topic><topic>Vertebrates: anatomy and physiology, studies on body, several organs or systems</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fogleman, April D.</creatorcontrib><creatorcontrib>Cohen, Ronald S.</creatorcontrib><creatorcontrib>Sakamoto, Pauline</creatorcontrib><creatorcontrib>Allen, Jonathan C.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of pediatric gastroenterology and nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fogleman, April D.</au><au>Cohen, Ronald S.</au><au>Sakamoto, Pauline</au><au>Allen, Jonathan C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of Added Calcium, Phosphorus, and Infant Formula on Calcium and Phosphorus Dialyzability in Preterm Donor Human Milk</atitle><jtitle>Journal of pediatric gastroenterology and nutrition</jtitle><addtitle>J Pediatr Gastroenterol Nutr</addtitle><date>2012-10</date><risdate>2012</risdate><volume>55</volume><issue>4</issue><spage>390</spage><epage>397</epage><pages>390-397</pages><issn>0277-2116</issn><eissn>1536-4801</eissn><coden>JPGND6</coden><abstract>ABSTRACT
Objectives:
We studied the effect of preparing donor human milk (DHM) with commonly used nutritional additives on the dialyzability of calcium and phosphate. We hypothesized that the additives to DHM would decrease the dialyzability of calcium and phosphate when prepared according to hospital protocols.
Methods:
An in vitro system simulating premature infant digestion was developed to measure dialyzability of calcium and phosphate in DHM. Dialyzable calcium and phosphate were measured after in vitro digestion in DHM before and after preparation of DHM with the following additives according to hospital protocols: calcium glubionate, sodium potassium phosphate, calcium glubionate and sodium potassium phosphate added together, Similac human milk fortifier, Similac NeoSure, or Enfamil Enfacare.
Results:
The percentage of dialyzable calcium in DHM with added calcium and calcium and phosphate together was greater than the percentage of dialyzable calcium in DHM with added powdered infant formulas (P < 0.0001). Dialyzable calcium was greater in DHM with added calcium and with added calcium and phosphate than in all other treatment groups (P < 0.0001). Dialyzable calcium in DHM without additives was not different from dialyzable calcium in DHM with added phosphate or with added powdered infant formulas. Dialyzable phosphate did not differ between the treatment groups.
Conclusions:
The addition of calcium alone or calcium and phosphate together increased calcium dialyzability in DHM significantly, whereas the addition of powdered human milk fortifier or formulas did not. The addition of calcium or calcium with phosphate together to DHM may provide the most dialyzable calcium.</abstract><cop>Hagerstown, MD</cop><pub>Copyright by ESPGHAN and NASPGHAN</pub><pmid>22437472</pmid><doi>10.1097/MPG.0b013e318254ec07</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0277-2116 |
| ispartof | Journal of pediatric gastroenterology and nutrition, 2012-10, Vol.55 (4), p.390-397 |
| issn | 0277-2116 1536-4801 |
| language | eng |
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| source | MEDLINE; Journals@Ovid Complete; Access via Wiley Online Library |
| subjects | Biological and medical sciences calcium Calcium, Dietary - metabolism dialyzability Diseases of mother, fetus and pregnancy donor human milk Feeding. Feeding behavior Food, Fortified fortification Fundamental and applied biological sciences. Psychology Gynecology. Andrology. Obstetrics Humans Infant Formula Infant, Newborn Infant, Premature Medical sciences Milk, Human phosphate Phosphates - metabolism Phosphorus, Dietary - metabolism Pregnancy. Fetus. Placenta Vertebrates: anatomy and physiology, studies on body, several organs or systems |
| title | Effect of Added Calcium, Phosphorus, and Infant Formula on Calcium and Phosphorus Dialyzability in Preterm Donor Human Milk |
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