Balance between excitation and inhibition controls the temporal organization of neuronal avalanches

Neuronal avalanches, measured in vitro and in vivo, exhibit a robust critical behavior. Their temporal organization hides the presence of correlations. Here we present experimental measurements of the waiting time distribution between successive avalanches in the rat cortex in vitro. This exhibits a...

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Veröffentlicht in:	Physical review letters 2012-05, Vol.108 (22), p.228703-228703, Article 228703
Hauptverfasser:	Lombardi, F, Herrmann, H J, Perrone-Capano, C, Plenz, D, de Arcangelis, L
Format:	Artikel
Sprache:	eng
Schlagworte:	Action Potentials - physiology Animals Models, Neurological Nerve Net - physiology Neurons - physiology Rats
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container_end_page	228703
container_issue	22
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container_title	Physical review letters
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creator	Lombardi, F Herrmann, H J Perrone-Capano, C Plenz, D de Arcangelis, L
description	Neuronal avalanches, measured in vitro and in vivo, exhibit a robust critical behavior. Their temporal organization hides the presence of correlations. Here we present experimental measurements of the waiting time distribution between successive avalanches in the rat cortex in vitro. This exhibits a nonmonotonic behavior not usually found in other natural processes. Numerical simulations provide evidence that this behavior is a consequence of the alternation between states of high and low activity, named up and down states, leading to a balance between excitation and inhibition controlled by a single parameter. During these periods, both the single neuron state and the network excitability level, keeping memory of past activity, are tuned by homeostatic mechanisms.
doi_str_mv	10.1103/physrevlett.108.228703
format	Article
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subjects	Action Potentials - physiology Animals Models, Neurological Nerve Net - physiology Neurons - physiology Rats
title	Balance between excitation and inhibition controls the temporal organization of neuronal avalanches
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