Association of LIPA Gene Polymorphisms With Obesity‐Related Metabolic Complications Among Severely Obese Patients

The lipase A, lysosomal acid, cholesterol esterase enzyme (LIPA) is involved in the hydrolysis of triglycerides (TGs) and cholesteryl esters (CEs) delivered to lysosomes. LIPA deficiency in human causes two distinct phenotypes characterized by intracellular storage of CE and derangements in the cont...

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Veröffentlicht in:	Obesity (Silver Spring, Md.) Md.), 2012-10, Vol.20 (10), p.2075-2082
Hauptverfasser:	Guénard, Frédéric, Houde, Alain, Bouchard, Luigi, Tchernof, André, Deshaies, Yves, Biron, Simon, Lescelleur, Odette, Biertho, Laurent, Marceau, Simon, Pérusse, Louis, Vohl, Marie‐Claude
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Cardiovascular Diseases - blood Cardiovascular Diseases - epidemiology Cardiovascular Diseases - genetics Cohort Studies Female Humans Male Metabolic Syndrome - blood Metabolic Syndrome - epidemiology Metabolic Syndrome - genetics Obesity, Morbid - blood Obesity, Morbid - epidemiology Obesity, Morbid - genetics Polymorphism, Genetic Polymorphism, Single Nucleotide Quebec - epidemiology Sequence Analysis, DNA Sterol Esterase - blood Sterol Esterase - genetics Triglycerides - blood Wolman Disease Wolman Disease - epidemiology Wolman Disease - genetics
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