Effect of Bifidobacterium administration on very-low-birthweight infants
Background: The aim of this study was to evaluate the efficacy and safety of early administration of Bifidobacterium bifidum OLB6378 (B. bifidum) on accelerating enteral feeding and bacterial colonization in very‐low‐birthweight (VLBW) infants. Methods: We conducted a single‐center prospective pil...
Gespeichert in:
| Veröffentlicht in: | Pediatrics international 2012-10, Vol.54 (5), p.651-656 |
|---|---|
| Hauptverfasser: | , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 656 |
|---|---|
| container_issue | 5 |
| container_start_page | 651 |
| container_title | Pediatrics international |
| container_volume | 54 |
| creator | Yamasaki, Chika Totsu, Satsuki Uchiyama, Atushi Nakanishi, Hidehiko Masumoto, Kenichi Washio, Yosuke Shuri, Kyoko Ishida, Shuji Imai, Ken Kusuda, Satoshi |
| description | Background: The aim of this study was to evaluate the efficacy and safety of early administration of Bifidobacterium bifidum OLB6378 (B. bifidum) on accelerating enteral feeding and bacterial colonization in very‐low‐birthweight (VLBW) infants.
Methods: We conducted a single‐center prospective pilot study. Thirty‐six VLBW infants were randomly divided into two groups: group E, wherein B. bifidum was supplemented within 48 h of birth, and group L, wherein it was supplemented more than 48 h after birth.
Results: Group E and group L reached a total feeding volume of 100 mL/(kg/day) after 10 [7–13] days and 11 [10–15] days, respectively (median [quartile]). The daily bodyweight gain in group E was significantly higher (21.4 ± 3.2 g/day vs 18.3 ± 4.0 g/day, P < 0.02; 11.1 ± 1.5 g/kg/day vs 10.4 ± 1.2 g/kg/day, P < 0.04). No significant differences were found in the fecal Bifidobacterium level between the groups quantitated with a real‐time polymerase chain reaction assay at 1 and 4 weeks of age. However, the highest colonization rate of Bifidobacterium was observed when the supplementation started between 24 and 48 h after birth. The incidence of morbidities between the groups was similar.
Conclusion: The early administration of B. bifidum to VLBW infants seems effective in promoting growth during the stay in the neonatal intensive care unit without increasing the incidence of morbidity. Furthermore, the preferable timing of starting the probiotic supplementation for VLBW infants is at latest less than 48 h after birth. |
| doi_str_mv | 10.1111/j.1442-200X.2012.03649.x |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1080616234</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2769699281</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4599-98d9ed6ff12bb6f4507e44fd0a59de958a23da2785fb7755b7e917fdbf0117913</originalsourceid><addsrcrecordid>eNqNkc1PHCEYh4mpqR_tv9BM0ksvMwLD56GHVtePRO0eNBovhBmgsp0PCzPd3f9exrV78CQh4U14fi_wAECGYIHSOFoUiBCcYwjvCwwRLmDJiCxWO2B_u_Eh1SUWuYCM74GDGBcQQsEF-Qj2MKaQl4Ltg_OZc7Yest5lP73zpq90PdjgxzbTpvWdj0PQg--7LM1_Nqzzpl_mlQ_D49L6349D5junuyF-ArtON9F-fl0Pwe3p7Ob4PL_8dXZx_OMyrwmVMpfCSGuYcwhXFXMk3cMS4gzUVBorqdC4NBpzQV3FOaUVtxJxZyoHEeISlYfg26bvU-j_jjYOqvWxtk2jO9uPUSGYHowYLklCv75BF_0YunS7RDGJpWQUJ0psqDr0MQbr1FPwrQ7rBKnJtlqoSaqapKrJtnqxrVYp-uX1gLFqrdkG_-tNwPcNsPSNXb-7sZrPTqYq5fNNPn2DXW3zOvxRjJecqrvrMyXm96dX87sHdVI-A6l-nRs</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1069299652</pqid></control><display><type>article</type><title>Effect of Bifidobacterium administration on very-low-birthweight infants</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Yamasaki, Chika ; Totsu, Satsuki ; Uchiyama, Atushi ; Nakanishi, Hidehiko ; Masumoto, Kenichi ; Washio, Yosuke ; Shuri, Kyoko ; Ishida, Shuji ; Imai, Ken ; Kusuda, Satoshi</creator><creatorcontrib>Yamasaki, Chika ; Totsu, Satsuki ; Uchiyama, Atushi ; Nakanishi, Hidehiko ; Masumoto, Kenichi ; Washio, Yosuke ; Shuri, Kyoko ; Ishida, Shuji ; Imai, Ken ; Kusuda, Satoshi</creatorcontrib><description>Background: The aim of this study was to evaluate the efficacy and safety of early administration of Bifidobacterium bifidum OLB6378 (B. bifidum) on accelerating enteral feeding and bacterial colonization in very‐low‐birthweight (VLBW) infants.
Methods: We conducted a single‐center prospective pilot study. Thirty‐six VLBW infants were randomly divided into two groups: group E, wherein B. bifidum was supplemented within 48 h of birth, and group L, wherein it was supplemented more than 48 h after birth.
Results: Group E and group L reached a total feeding volume of 100 mL/(kg/day) after 10 [7–13] days and 11 [10–15] days, respectively (median [quartile]). The daily bodyweight gain in group E was significantly higher (21.4 ± 3.2 g/day vs 18.3 ± 4.0 g/day, P < 0.02; 11.1 ± 1.5 g/kg/day vs 10.4 ± 1.2 g/kg/day, P < 0.04). No significant differences were found in the fecal Bifidobacterium level between the groups quantitated with a real‐time polymerase chain reaction assay at 1 and 4 weeks of age. However, the highest colonization rate of Bifidobacterium was observed when the supplementation started between 24 and 48 h after birth. The incidence of morbidities between the groups was similar.
Conclusion: The early administration of B. bifidum to VLBW infants seems effective in promoting growth during the stay in the neonatal intensive care unit without increasing the incidence of morbidity. Furthermore, the preferable timing of starting the probiotic supplementation for VLBW infants is at latest less than 48 h after birth.</description><identifier>ISSN: 1328-8067</identifier><identifier>EISSN: 1442-200X</identifier><identifier>DOI: 10.1111/j.1442-200X.2012.03649.x</identifier><identifier>PMID: 22507386</identifier><language>eng</language><publisher>Melbourne, Australia: Blackwell Publishing Asia</publisher><subject>Babies ; Bacteria ; Bifidobacterium ; Bifidobacterium bifidum ; Birth weight ; Child Development ; colonization ; Dietary Supplements ; Drug therapy ; enteral feeding ; Enteral Nutrition ; Female ; Humans ; Incidence ; Infant, Newborn ; Infant, Very Low Birth Weight - growth & development ; Male ; Metagenome - genetics ; Pilot Projects ; probiotics ; Probiotics - administration & dosage ; Probiotics - adverse effects ; Prospective Studies ; Real-Time Polymerase Chain Reaction</subject><ispartof>Pediatrics international, 2012-10, Vol.54 (5), p.651-656</ispartof><rights>2012 The Authors. Pediatrics International © 2012 Japan Pediatric Society</rights><rights>2012 The Authors. Pediatrics International © 2012 Japan Pediatric Society.</rights><rights>Pediatrics International © 2012 Japan Pediatric Society</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4599-98d9ed6ff12bb6f4507e44fd0a59de958a23da2785fb7755b7e917fdbf0117913</citedby><cites>FETCH-LOGICAL-c4599-98d9ed6ff12bb6f4507e44fd0a59de958a23da2785fb7755b7e917fdbf0117913</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1442-200X.2012.03649.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1442-200X.2012.03649.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22507386$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yamasaki, Chika</creatorcontrib><creatorcontrib>Totsu, Satsuki</creatorcontrib><creatorcontrib>Uchiyama, Atushi</creatorcontrib><creatorcontrib>Nakanishi, Hidehiko</creatorcontrib><creatorcontrib>Masumoto, Kenichi</creatorcontrib><creatorcontrib>Washio, Yosuke</creatorcontrib><creatorcontrib>Shuri, Kyoko</creatorcontrib><creatorcontrib>Ishida, Shuji</creatorcontrib><creatorcontrib>Imai, Ken</creatorcontrib><creatorcontrib>Kusuda, Satoshi</creatorcontrib><title>Effect of Bifidobacterium administration on very-low-birthweight infants</title><title>Pediatrics international</title><addtitle>Pediatr Int</addtitle><description>Background: The aim of this study was to evaluate the efficacy and safety of early administration of Bifidobacterium bifidum OLB6378 (B. bifidum) on accelerating enteral feeding and bacterial colonization in very‐low‐birthweight (VLBW) infants.
Methods: We conducted a single‐center prospective pilot study. Thirty‐six VLBW infants were randomly divided into two groups: group E, wherein B. bifidum was supplemented within 48 h of birth, and group L, wherein it was supplemented more than 48 h after birth.
Results: Group E and group L reached a total feeding volume of 100 mL/(kg/day) after 10 [7–13] days and 11 [10–15] days, respectively (median [quartile]). The daily bodyweight gain in group E was significantly higher (21.4 ± 3.2 g/day vs 18.3 ± 4.0 g/day, P < 0.02; 11.1 ± 1.5 g/kg/day vs 10.4 ± 1.2 g/kg/day, P < 0.04). No significant differences were found in the fecal Bifidobacterium level between the groups quantitated with a real‐time polymerase chain reaction assay at 1 and 4 weeks of age. However, the highest colonization rate of Bifidobacterium was observed when the supplementation started between 24 and 48 h after birth. The incidence of morbidities between the groups was similar.
Conclusion: The early administration of B. bifidum to VLBW infants seems effective in promoting growth during the stay in the neonatal intensive care unit without increasing the incidence of morbidity. Furthermore, the preferable timing of starting the probiotic supplementation for VLBW infants is at latest less than 48 h after birth.</description><subject>Babies</subject><subject>Bacteria</subject><subject>Bifidobacterium</subject><subject>Bifidobacterium bifidum</subject><subject>Birth weight</subject><subject>Child Development</subject><subject>colonization</subject><subject>Dietary Supplements</subject><subject>Drug therapy</subject><subject>enteral feeding</subject><subject>Enteral Nutrition</subject><subject>Female</subject><subject>Humans</subject><subject>Incidence</subject><subject>Infant, Newborn</subject><subject>Infant, Very Low Birth Weight - growth & development</subject><subject>Male</subject><subject>Metagenome - genetics</subject><subject>Pilot Projects</subject><subject>probiotics</subject><subject>Probiotics - administration & dosage</subject><subject>Probiotics - adverse effects</subject><subject>Prospective Studies</subject><subject>Real-Time Polymerase Chain Reaction</subject><issn>1328-8067</issn><issn>1442-200X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkc1PHCEYh4mpqR_tv9BM0ksvMwLD56GHVtePRO0eNBovhBmgsp0PCzPd3f9exrV78CQh4U14fi_wAECGYIHSOFoUiBCcYwjvCwwRLmDJiCxWO2B_u_Eh1SUWuYCM74GDGBcQQsEF-Qj2MKaQl4Ltg_OZc7Yest5lP73zpq90PdjgxzbTpvWdj0PQg--7LM1_Nqzzpl_mlQ_D49L6349D5junuyF-ArtON9F-fl0Pwe3p7Ob4PL_8dXZx_OMyrwmVMpfCSGuYcwhXFXMk3cMS4gzUVBorqdC4NBpzQV3FOaUVtxJxZyoHEeISlYfg26bvU-j_jjYOqvWxtk2jO9uPUSGYHowYLklCv75BF_0YunS7RDGJpWQUJ0psqDr0MQbr1FPwrQ7rBKnJtlqoSaqapKrJtnqxrVYp-uX1gLFqrdkG_-tNwPcNsPSNXb-7sZrPTqYq5fNNPn2DXW3zOvxRjJecqrvrMyXm96dX87sHdVI-A6l-nRs</recordid><startdate>201210</startdate><enddate>201210</enddate><creator>Yamasaki, Chika</creator><creator>Totsu, Satsuki</creator><creator>Uchiyama, Atushi</creator><creator>Nakanishi, Hidehiko</creator><creator>Masumoto, Kenichi</creator><creator>Washio, Yosuke</creator><creator>Shuri, Kyoko</creator><creator>Ishida, Shuji</creator><creator>Imai, Ken</creator><creator>Kusuda, Satoshi</creator><general>Blackwell Publishing Asia</general><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7U9</scope><scope>H94</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>201210</creationdate><title>Effect of Bifidobacterium administration on very-low-birthweight infants</title><author>Yamasaki, Chika ; Totsu, Satsuki ; Uchiyama, Atushi ; Nakanishi, Hidehiko ; Masumoto, Kenichi ; Washio, Yosuke ; Shuri, Kyoko ; Ishida, Shuji ; Imai, Ken ; Kusuda, Satoshi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4599-98d9ed6ff12bb6f4507e44fd0a59de958a23da2785fb7755b7e917fdbf0117913</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Babies</topic><topic>Bacteria</topic><topic>Bifidobacterium</topic><topic>Bifidobacterium bifidum</topic><topic>Birth weight</topic><topic>Child Development</topic><topic>colonization</topic><topic>Dietary Supplements</topic><topic>Drug therapy</topic><topic>enteral feeding</topic><topic>Enteral Nutrition</topic><topic>Female</topic><topic>Humans</topic><topic>Incidence</topic><topic>Infant, Newborn</topic><topic>Infant, Very Low Birth Weight - growth & development</topic><topic>Male</topic><topic>Metagenome - genetics</topic><topic>Pilot Projects</topic><topic>probiotics</topic><topic>Probiotics - administration & dosage</topic><topic>Probiotics - adverse effects</topic><topic>Prospective Studies</topic><topic>Real-Time Polymerase Chain Reaction</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yamasaki, Chika</creatorcontrib><creatorcontrib>Totsu, Satsuki</creatorcontrib><creatorcontrib>Uchiyama, Atushi</creatorcontrib><creatorcontrib>Nakanishi, Hidehiko</creatorcontrib><creatorcontrib>Masumoto, Kenichi</creatorcontrib><creatorcontrib>Washio, Yosuke</creatorcontrib><creatorcontrib>Shuri, Kyoko</creatorcontrib><creatorcontrib>Ishida, Shuji</creatorcontrib><creatorcontrib>Imai, Ken</creatorcontrib><creatorcontrib>Kusuda, Satoshi</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Pediatrics international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yamasaki, Chika</au><au>Totsu, Satsuki</au><au>Uchiyama, Atushi</au><au>Nakanishi, Hidehiko</au><au>Masumoto, Kenichi</au><au>Washio, Yosuke</au><au>Shuri, Kyoko</au><au>Ishida, Shuji</au><au>Imai, Ken</au><au>Kusuda, Satoshi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of Bifidobacterium administration on very-low-birthweight infants</atitle><jtitle>Pediatrics international</jtitle><addtitle>Pediatr Int</addtitle><date>2012-10</date><risdate>2012</risdate><volume>54</volume><issue>5</issue><spage>651</spage><epage>656</epage><pages>651-656</pages><issn>1328-8067</issn><eissn>1442-200X</eissn><abstract>Background: The aim of this study was to evaluate the efficacy and safety of early administration of Bifidobacterium bifidum OLB6378 (B. bifidum) on accelerating enteral feeding and bacterial colonization in very‐low‐birthweight (VLBW) infants.
Methods: We conducted a single‐center prospective pilot study. Thirty‐six VLBW infants were randomly divided into two groups: group E, wherein B. bifidum was supplemented within 48 h of birth, and group L, wherein it was supplemented more than 48 h after birth.
Results: Group E and group L reached a total feeding volume of 100 mL/(kg/day) after 10 [7–13] days and 11 [10–15] days, respectively (median [quartile]). The daily bodyweight gain in group E was significantly higher (21.4 ± 3.2 g/day vs 18.3 ± 4.0 g/day, P < 0.02; 11.1 ± 1.5 g/kg/day vs 10.4 ± 1.2 g/kg/day, P < 0.04). No significant differences were found in the fecal Bifidobacterium level between the groups quantitated with a real‐time polymerase chain reaction assay at 1 and 4 weeks of age. However, the highest colonization rate of Bifidobacterium was observed when the supplementation started between 24 and 48 h after birth. The incidence of morbidities between the groups was similar.
Conclusion: The early administration of B. bifidum to VLBW infants seems effective in promoting growth during the stay in the neonatal intensive care unit without increasing the incidence of morbidity. Furthermore, the preferable timing of starting the probiotic supplementation for VLBW infants is at latest less than 48 h after birth.</abstract><cop>Melbourne, Australia</cop><pub>Blackwell Publishing Asia</pub><pmid>22507386</pmid><doi>10.1111/j.1442-200X.2012.03649.x</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1328-8067 |
| ispartof | Pediatrics international, 2012-10, Vol.54 (5), p.651-656 |
| issn | 1328-8067 1442-200X |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1080616234 |
| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Babies Bacteria Bifidobacterium Bifidobacterium bifidum Birth weight Child Development colonization Dietary Supplements Drug therapy enteral feeding Enteral Nutrition Female Humans Incidence Infant, Newborn Infant, Very Low Birth Weight - growth & development Male Metagenome - genetics Pilot Projects probiotics Probiotics - administration & dosage Probiotics - adverse effects Prospective Studies Real-Time Polymerase Chain Reaction |
| title | Effect of Bifidobacterium administration on very-low-birthweight infants |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-12T21%3A46%3A52IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Effect%20of%20Bifidobacterium%20administration%20on%20very-low-birthweight%20infants&rft.jtitle=Pediatrics%20international&rft.au=Yamasaki,%20Chika&rft.date=2012-10&rft.volume=54&rft.issue=5&rft.spage=651&rft.epage=656&rft.pages=651-656&rft.issn=1328-8067&rft.eissn=1442-200X&rft_id=info:doi/10.1111/j.1442-200X.2012.03649.x&rft_dat=%3Cproquest_cross%3E2769699281%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1069299652&rft_id=info:pmid/22507386&rfr_iscdi=true |