Genetic instability and CpG methylation in the 5'-flanking region of the PAI-1 gene in Chinese patients with gastric cancer

We explored a possible correlation of genetic instability and CpG methylation in the 5'-flanking region of the PAI-1 gene with clinicopathologic features of gastric cancer in Chinese patients and looked for molecular markers for diagnosing gastric tumor development. Microsatellite instability a...

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Veröffentlicht in:	Genetics and molecular research 2012-01, Vol.11 (3), p.2899-2908
Hauptverfasser:	Liu, J, Li, X, Yu, N, Yang, Y-Q, Ye, Z-Y, Li, J-C
Format:	Artikel
Sprache:	eng
Schlagworte:	5' Flanking Region - genetics Alleles Asian Continental Ancestry Group - genetics China CpG Islands - genetics DNA Methylation - genetics Genetic Loci - genetics Genetic Predisposition to Disease Genomic Instability - genetics Humans Loss of Heterozygosity - genetics Microsatellite Instability Plasminogen Activator Inhibitor 1 - genetics Polymerase Chain Reaction Stomach Neoplasms - genetics Stomach Neoplasms - pathology
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