Identification of CXCL5/ENA-78 as a factor involved in the interaction between cholangiocarcinoma cells and cancer-associated fibroblasts

Knowledge of tumor‐stromal interactions is essential for understanding tumor development. We focused on the interaction between cholangiocarcinoma and cancer‐associated fibroblasts (CAFs) in intrahepatic cholangiocarcinoma and reported their positive interaction in vitro and in vivo. The aim of this...

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Veröffentlicht in:	International journal of cancer 2012-11, Vol.131 (10), p.2234-2241
Hauptverfasser:	Okabe, Hirohisa, Beppu, Toru, Ueda, Mitsuharu, Hayashi, Hiromitsu, Ishiko, Takatoshi, Masuda, Toshiro, Otao, Ryu, Horlad, Hasita, Mima, Kosuke, Miyake, Keisuke, Iwatsuki, Masaaki, Baba, Yoshifumi, Takamori, Hiroshi, Jono, Hirofumi, Shinriki, Satoru, Ando, Yukio, Baba, Hideo
Format:	Artikel
Sprache:	eng
Schlagworte:	Actins - metabolism Adult Aged Aged, 80 and over Antigens, CD - metabolism Bile Duct Neoplasms Bile Ducts, Intrahepatic Biological and medical sciences Cancer Cancer therapies cancer-associated fibroblasts Cell Adhesion Molecules - metabolism Cell Communication Cell Line, Tumor Cell Movement - drug effects Cell Proliferation - drug effects Cells Chemokine CXCL5 - genetics Chemokine CXCL5 - metabolism cholangiocarcinoma Cholangiocarcinoma - metabolism Cholangiocarcinoma - mortality Cholangiocarcinoma - pathology Coculture Techniques Culture Media, Conditioned - pharmacology CXCL5 Enzyme Activation - drug effects Female Fibroblasts - metabolism Gastroenterology. Liver. Pancreas. Abdomen Gene Expression Regulation, Neoplastic GPI-Linked Proteins - metabolism hepatic stellate cell Hepatic Stellate Cells - metabolism Humans IL-1β Interleukin-1beta - pharmacology Liver Neoplasms - metabolism Liver Neoplasms - mortality Liver Neoplasms - pathology Liver. Biliary tract. Portal circulation. Exocrine pancreas Male Medical research Medical sciences Middle Aged Mitogen-Activated Protein Kinase 1 - metabolism Mitogen-Activated Protein Kinase 3 - metabolism Neutrophil Infiltration Prognosis Proteins Proto-Oncogene Proteins c-akt - metabolism Tumors
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