Tumor Necrosis Factor Gene Variation Predicts Hippocampus Volume in Healthy Individuals
Background Cytokines such as tumor necrosis factor (TNF) α have been implicated in neurodegeneration relevant to various neuropsychiatric disorders. Little is known about the genetic predisposition to neurodegenerative properties of cytokine genes on brain function and on hippocampus (HC) function i...
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| Veröffentlicht in: | Biological psychiatry (1969) 2012-10, Vol.72 (8), p.655-662 |
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| creator | Baune, Bernhard T Konrad, Carsten Grotegerd, Dominik Suslow, Thomas Ohrmann, Patricia Bauer, Jochen Arolt, Volker Heindel, Walter Domschke, Katharina Schöning, Sonja Rauch, Astrid Veronika Sehlmeyer, Christina Kugel, Harald Dannlowski, Udo |
| description | Background Cytokines such as tumor necrosis factor (TNF) α have been implicated in neurodegeneration relevant to various neuropsychiatric disorders. Little is known about the genetic predisposition to neurodegenerative properties of cytokine genes on brain function and on hippocampus (HC) function in particular. In this study we investigate the neurodegenerative role of TNF polymorphisms on brain morphology in healthy individuals. Methods Voxel-based morphometry was used in a large sample of healthy individuals ( n = 303) to analyze the associations between genetic variants of TNF (rs1800629; rs361525) and brain morphology (gray matter concentration). Results In a region of interest analysis of the HC, for rs1800629, we observed a strong genotype effect on bilateral HC gray matter concentration. Carriers of one or two A-alleles had significantly smaller volumes compared with GG-homozygotes. For rs361525, a similar effect was observed at almost the same location, with the A-allele resulting in smaller HC volumes compared with GG homozygotes. Conclusions The findings suggest a neurodegenerative role of the A-alleles of the TNF single nucleotide polymorphisms rs1800629 (-308G/A) and rs361525 (-238G/A) on hippocampal volumes in healthy individuals. Future imaging studies on the role of these single nucleotide polymorphisms in psychiatric populations of diseases with neurodegenerative components are warranted. |
| doi_str_mv | 10.1016/j.biopsych.2012.04.002 |
| format | Article |
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Little is known about the genetic predisposition to neurodegenerative properties of cytokine genes on brain function and on hippocampus (HC) function in particular. In this study we investigate the neurodegenerative role of TNF polymorphisms on brain morphology in healthy individuals. Methods Voxel-based morphometry was used in a large sample of healthy individuals ( n = 303) to analyze the associations between genetic variants of TNF (rs1800629; rs361525) and brain morphology (gray matter concentration). Results In a region of interest analysis of the HC, for rs1800629, we observed a strong genotype effect on bilateral HC gray matter concentration. Carriers of one or two A-alleles had significantly smaller volumes compared with GG-homozygotes. For rs361525, a similar effect was observed at almost the same location, with the A-allele resulting in smaller HC volumes compared with GG homozygotes. Conclusions The findings suggest a neurodegenerative role of the A-alleles of the TNF single nucleotide polymorphisms rs1800629 (-308G/A) and rs361525 (-238G/A) on hippocampal volumes in healthy individuals. Future imaging studies on the role of these single nucleotide polymorphisms in psychiatric populations of diseases with neurodegenerative components are warranted.</description><identifier>ISSN: 0006-3223</identifier><identifier>EISSN: 1873-2402</identifier><identifier>DOI: 10.1016/j.biopsych.2012.04.002</identifier><identifier>PMID: 22554453</identifier><identifier>CODEN: BIPCBF</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Adolescent ; Adult ; Aged ; Biological and medical sciences ; Female ; Genetic Predisposition to Disease ; Genotype ; Hippocampus ; Hippocampus - anatomy & histology ; Humans ; Image Processing, Computer-Assisted ; imaging genetics ; Magnetic Resonance Imaging ; Male ; Medical sciences ; Middle Aged ; MRI ; neurodegeneration ; Polymorphism, Single Nucleotide - genetics ; Psychiatry ; Psychology. Psychoanalysis. Psychiatry ; Psychopathology. Psychiatry ; TNF ; Tumor Necrosis Factor-alpha - genetics ; voxel-based morphometry ; Young Adult</subject><ispartof>Biological psychiatry (1969), 2012-10, Vol.72 (8), p.655-662</ispartof><rights>Society of Biological Psychiatry</rights><rights>2012 Society of Biological Psychiatry</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2012 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c519t-e19729c9f9996d48ddf1bb39fc1d45e75e1ba15876221b0bb1ffa0906e6016233</citedby><cites>FETCH-LOGICAL-c519t-e19729c9f9996d48ddf1bb39fc1d45e75e1ba15876221b0bb1ffa0906e6016233</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0006322312003101$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=26403787$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22554453$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Baune, Bernhard T</creatorcontrib><creatorcontrib>Konrad, Carsten</creatorcontrib><creatorcontrib>Grotegerd, Dominik</creatorcontrib><creatorcontrib>Suslow, Thomas</creatorcontrib><creatorcontrib>Ohrmann, Patricia</creatorcontrib><creatorcontrib>Bauer, Jochen</creatorcontrib><creatorcontrib>Arolt, Volker</creatorcontrib><creatorcontrib>Heindel, Walter</creatorcontrib><creatorcontrib>Domschke, Katharina</creatorcontrib><creatorcontrib>Schöning, Sonja</creatorcontrib><creatorcontrib>Rauch, Astrid Veronika</creatorcontrib><creatorcontrib>Sehlmeyer, Christina</creatorcontrib><creatorcontrib>Kugel, Harald</creatorcontrib><creatorcontrib>Dannlowski, Udo</creatorcontrib><title>Tumor Necrosis Factor Gene Variation Predicts Hippocampus Volume in Healthy Individuals</title><title>Biological psychiatry (1969)</title><addtitle>Biol Psychiatry</addtitle><description>Background Cytokines such as tumor necrosis factor (TNF) α have been implicated in neurodegeneration relevant to various neuropsychiatric disorders. Little is known about the genetic predisposition to neurodegenerative properties of cytokine genes on brain function and on hippocampus (HC) function in particular. In this study we investigate the neurodegenerative role of TNF polymorphisms on brain morphology in healthy individuals. Methods Voxel-based morphometry was used in a large sample of healthy individuals ( n = 303) to analyze the associations between genetic variants of TNF (rs1800629; rs361525) and brain morphology (gray matter concentration). Results In a region of interest analysis of the HC, for rs1800629, we observed a strong genotype effect on bilateral HC gray matter concentration. Carriers of one or two A-alleles had significantly smaller volumes compared with GG-homozygotes. For rs361525, a similar effect was observed at almost the same location, with the A-allele resulting in smaller HC volumes compared with GG homozygotes. Conclusions The findings suggest a neurodegenerative role of the A-alleles of the TNF single nucleotide polymorphisms rs1800629 (-308G/A) and rs361525 (-238G/A) on hippocampal volumes in healthy individuals. Future imaging studies on the role of these single nucleotide polymorphisms in psychiatric populations of diseases with neurodegenerative components are warranted.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Female</subject><subject>Genetic Predisposition to Disease</subject><subject>Genotype</subject><subject>Hippocampus</subject><subject>Hippocampus - anatomy & histology</subject><subject>Humans</subject><subject>Image Processing, Computer-Assisted</subject><subject>imaging genetics</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>MRI</subject><subject>neurodegeneration</subject><subject>Polymorphism, Single Nucleotide - genetics</subject><subject>Psychiatry</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopathology. Psychiatry</subject><subject>TNF</subject><subject>Tumor Necrosis Factor-alpha - genetics</subject><subject>voxel-based morphometry</subject><subject>Young Adult</subject><issn>0006-3223</issn><issn>1873-2402</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkktr3DAQgEVpSbbb_IWgS6EXu3rY8upSWkKSDYS20DyOQpbGRFtbciU7sP--MrtpoZeehoFvHvo0CJ1TUlJCxcdd2bowpr15KhmhrCRVSQh7hVZ00_CCVYS9RitCiCg4Y_wUvU1pl9OGMXqCThmr66qq-Qo93s1DiPgrmBiSS_hKmynn1-ABP-jo9OSCx98jWGemhLduHIPRwzgn_BD6eQDsPN6C7qenPb7x1j07O-s-vUNvuhzg7BjX6P7q8u5iW9x-u765-HJbmJrKqQAqGyaN7KSUwlYbazvatlx2htqqhqYG2mpabxqRF29J29Ku00QSASJbYJyv0YdD3zGGXzOkSQ0uGeh77SHMSVHSVI0QVLKMigO6PDVF6NQY3aDjPkNqkap26kWqWqQqUqksNReeH2fM7QD2T9mLxQy8PwI6Gd13UXvj0l9OVIQ3-V_W6POBg2zk2UFUyTjwJsuNYCZlg_v_Lp_-aWF6512e-hP2kHZhjj77VlSlXKN-LCewXABlhPDcmP8GgzCtXA</recordid><startdate>20121015</startdate><enddate>20121015</enddate><creator>Baune, Bernhard T</creator><creator>Konrad, Carsten</creator><creator>Grotegerd, Dominik</creator><creator>Suslow, Thomas</creator><creator>Ohrmann, Patricia</creator><creator>Bauer, Jochen</creator><creator>Arolt, Volker</creator><creator>Heindel, Walter</creator><creator>Domschke, Katharina</creator><creator>Schöning, Sonja</creator><creator>Rauch, Astrid Veronika</creator><creator>Sehlmeyer, Christina</creator><creator>Kugel, Harald</creator><creator>Dannlowski, Udo</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20121015</creationdate><title>Tumor Necrosis Factor Gene Variation Predicts Hippocampus Volume in Healthy Individuals</title><author>Baune, Bernhard T ; Konrad, Carsten ; Grotegerd, Dominik ; Suslow, Thomas ; Ohrmann, Patricia ; Bauer, Jochen ; Arolt, Volker ; Heindel, Walter ; Domschke, Katharina ; Schöning, Sonja ; Rauch, Astrid Veronika ; Sehlmeyer, Christina ; Kugel, Harald ; Dannlowski, Udo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c519t-e19729c9f9996d48ddf1bb39fc1d45e75e1ba15876221b0bb1ffa0906e6016233</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Female</topic><topic>Genetic Predisposition to Disease</topic><topic>Genotype</topic><topic>Hippocampus</topic><topic>Hippocampus - anatomy & histology</topic><topic>Humans</topic><topic>Image Processing, Computer-Assisted</topic><topic>imaging genetics</topic><topic>Magnetic Resonance Imaging</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>MRI</topic><topic>neurodegeneration</topic><topic>Polymorphism, Single Nucleotide - genetics</topic><topic>Psychiatry</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopathology. Psychiatry</topic><topic>TNF</topic><topic>Tumor Necrosis Factor-alpha - genetics</topic><topic>voxel-based morphometry</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Baune, Bernhard T</creatorcontrib><creatorcontrib>Konrad, Carsten</creatorcontrib><creatorcontrib>Grotegerd, Dominik</creatorcontrib><creatorcontrib>Suslow, Thomas</creatorcontrib><creatorcontrib>Ohrmann, Patricia</creatorcontrib><creatorcontrib>Bauer, Jochen</creatorcontrib><creatorcontrib>Arolt, Volker</creatorcontrib><creatorcontrib>Heindel, Walter</creatorcontrib><creatorcontrib>Domschke, Katharina</creatorcontrib><creatorcontrib>Schöning, Sonja</creatorcontrib><creatorcontrib>Rauch, Astrid Veronika</creatorcontrib><creatorcontrib>Sehlmeyer, Christina</creatorcontrib><creatorcontrib>Kugel, Harald</creatorcontrib><creatorcontrib>Dannlowski, Udo</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Biological psychiatry (1969)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Baune, Bernhard T</au><au>Konrad, Carsten</au><au>Grotegerd, Dominik</au><au>Suslow, Thomas</au><au>Ohrmann, Patricia</au><au>Bauer, Jochen</au><au>Arolt, Volker</au><au>Heindel, Walter</au><au>Domschke, Katharina</au><au>Schöning, Sonja</au><au>Rauch, Astrid Veronika</au><au>Sehlmeyer, Christina</au><au>Kugel, Harald</au><au>Dannlowski, Udo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Tumor Necrosis Factor Gene Variation Predicts Hippocampus Volume in Healthy Individuals</atitle><jtitle>Biological psychiatry (1969)</jtitle><addtitle>Biol Psychiatry</addtitle><date>2012-10-15</date><risdate>2012</risdate><volume>72</volume><issue>8</issue><spage>655</spage><epage>662</epage><pages>655-662</pages><issn>0006-3223</issn><eissn>1873-2402</eissn><coden>BIPCBF</coden><abstract>Background Cytokines such as tumor necrosis factor (TNF) α have been implicated in neurodegeneration relevant to various neuropsychiatric disorders. Little is known about the genetic predisposition to neurodegenerative properties of cytokine genes on brain function and on hippocampus (HC) function in particular. In this study we investigate the neurodegenerative role of TNF polymorphisms on brain morphology in healthy individuals. Methods Voxel-based morphometry was used in a large sample of healthy individuals ( n = 303) to analyze the associations between genetic variants of TNF (rs1800629; rs361525) and brain morphology (gray matter concentration). Results In a region of interest analysis of the HC, for rs1800629, we observed a strong genotype effect on bilateral HC gray matter concentration. Carriers of one or two A-alleles had significantly smaller volumes compared with GG-homozygotes. For rs361525, a similar effect was observed at almost the same location, with the A-allele resulting in smaller HC volumes compared with GG homozygotes. Conclusions The findings suggest a neurodegenerative role of the A-alleles of the TNF single nucleotide polymorphisms rs1800629 (-308G/A) and rs361525 (-238G/A) on hippocampal volumes in healthy individuals. Future imaging studies on the role of these single nucleotide polymorphisms in psychiatric populations of diseases with neurodegenerative components are warranted.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>22554453</pmid><doi>10.1016/j.biopsych.2012.04.002</doi><tpages>8</tpages></addata></record> |
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| subjects | Adolescent Adult Aged Biological and medical sciences Female Genetic Predisposition to Disease Genotype Hippocampus Hippocampus - anatomy & histology Humans Image Processing, Computer-Assisted imaging genetics Magnetic Resonance Imaging Male Medical sciences Middle Aged MRI neurodegeneration Polymorphism, Single Nucleotide - genetics Psychiatry Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry TNF Tumor Necrosis Factor-alpha - genetics voxel-based morphometry Young Adult |
| title | Tumor Necrosis Factor Gene Variation Predicts Hippocampus Volume in Healthy Individuals |
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