Bladder urotoxicity pathophysiology induced by the oxazaphosphorine alkylating agents and its chemoprevention
The use of oxazaphosphorines (cyclophosphamide, ifosfamide) in the treatment of numerous neoplastic disorders is associated with their essential adverse effect in the form of hemorrhagic cystitis, which considerably limits the safety and efficacy of their pharmacotherapy. HC is a complex inflammator...
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| Veröffentlicht in: | Postȩpy higieny i medycyny doświadczalnej 2012-09, Vol.66, p.592-602 |
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| container_title | Postȩpy higieny i medycyny doświadczalnej |
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| creator | Dobrek, Łukasz Thor, Piotr Jan |
| description | The use of oxazaphosphorines (cyclophosphamide, ifosfamide) in the treatment of numerous neoplastic disorders is associated with their essential adverse effect in the form of hemorrhagic cystitis, which considerably limits the safety and efficacy of their pharmacotherapy. HC is a complex inflammatory response, induced by toxic oxazaphosphorines metabolite - acrolein with subsequent immunocompetetive cells activation and release of many proinflammatory agents. However, there are some chemoprotectant agents which help reduce the HC exacerbation. The article briefly discuses the mechanism of action of oxazaphosphorines, the pathophysiology of the hemorrhagic cystitis development and currently accepted chemopreventive agents, applied to the objective of urotoxicity amelioration. Moreover, the rationale for some phytopharmaceuticals administration as novel bladder protective compounds accompanying cyclophosphamide or ifosfamide therapy was also mentioned. |
| doi_str_mv | 10.5604/17322693.1009703 |
| format | Article |
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HC is a complex inflammatory response, induced by toxic oxazaphosphorines metabolite - acrolein with subsequent immunocompetetive cells activation and release of many proinflammatory agents. However, there are some chemoprotectant agents which help reduce the HC exacerbation. The article briefly discuses the mechanism of action of oxazaphosphorines, the pathophysiology of the hemorrhagic cystitis development and currently accepted chemopreventive agents, applied to the objective of urotoxicity amelioration. 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Moreover, the rationale for some phytopharmaceuticals administration as novel bladder protective compounds accompanying cyclophosphamide or ifosfamide therapy was also mentioned. </description><subject>Animals</subject><subject>Antineoplastic Agents, Alkylating - adverse effects</subject><subject>Chemoprevention</subject><subject>Cyclophosphamide - adverse effects</subject><subject>Cyclophosphamide - pharmacology</subject><subject>Cystitis - chemically induced</subject><subject>Cystitis - prevention & control</subject><subject>Cytoprotection</subject><subject>Hemorrhage - chemically induced</subject><subject>Hemorrhage - prevention & control</subject><subject>Humans</subject><subject>Ifosfamide - adverse effects</subject><subject>Protective Agents - therapeutic use</subject><subject>Urinary Bladder - drug effects</subject><issn>1732-2693</issn><issn>1732-2693</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpNUE1LxDAUDKK4su7dk-TopWvSpE171MUvWPCi55Imr9to29Skla2_3iy7Kz54zGOYGR6D0BUlyyQl_JYKFsdpzpaUkFwQdoIudlS0407_3TO08P6DhOF5mmf0HM1iRgiNCb1A7X0jtQaHR2cHuzXKDBPu5VDbvp68sY3dTNh0elSgcTnhoQZst_JH9rX1YZ3pAMvmc2rkYLoNlhvoBo9lp7EJqGpobe_gO7DGdpforJKNh8UB5-j98eFt9RytX59eVnfrSDFOhwhAa0LSKmCZ8BKSJJMx0SA4Z4xqkQvNdZVJlUqekkzr8JxiMVWciYoqYHN0s8_tnf0awQ9Fa7yCppEd2NEXlAgu0iTP4yAle6ly1nsHVdE700o3BVGx67k49lwceg6W60P6WLag_wzHVtkvb2l7pQ</recordid><startdate>20120910</startdate><enddate>20120910</enddate><creator>Dobrek, Łukasz</creator><creator>Thor, Piotr Jan</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20120910</creationdate><title>Bladder urotoxicity pathophysiology induced by the oxazaphosphorine alkylating agents and its chemoprevention</title><author>Dobrek, Łukasz ; Thor, Piotr Jan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c341t-eedd006feedb54be558a20de744331d797d4df8ac6a4608ddcedc321c437f1ce3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Animals</topic><topic>Antineoplastic Agents, Alkylating - adverse effects</topic><topic>Chemoprevention</topic><topic>Cyclophosphamide - adverse effects</topic><topic>Cyclophosphamide - pharmacology</topic><topic>Cystitis - chemically induced</topic><topic>Cystitis - prevention & control</topic><topic>Cytoprotection</topic><topic>Hemorrhage - chemically induced</topic><topic>Hemorrhage - prevention & control</topic><topic>Humans</topic><topic>Ifosfamide - adverse effects</topic><topic>Protective Agents - therapeutic use</topic><topic>Urinary Bladder - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Dobrek, Łukasz</creatorcontrib><creatorcontrib>Thor, Piotr Jan</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Postȩpy higieny i medycyny doświadczalnej</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Dobrek, Łukasz</au><au>Thor, Piotr Jan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Bladder urotoxicity pathophysiology induced by the oxazaphosphorine alkylating agents and its chemoprevention</atitle><jtitle>Postȩpy higieny i medycyny doświadczalnej</jtitle><addtitle>Postepy Hig Med Dosw (Online)</addtitle><date>2012-09-10</date><risdate>2012</risdate><volume>66</volume><spage>592</spage><epage>602</epage><pages>592-602</pages><issn>1732-2693</issn><eissn>1732-2693</eissn><abstract>The use of oxazaphosphorines (cyclophosphamide, ifosfamide) in the treatment of numerous neoplastic disorders is associated with their essential adverse effect in the form of hemorrhagic cystitis, which considerably limits the safety and efficacy of their pharmacotherapy. 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| fulltext | fulltext |
| identifier | ISSN: 1732-2693 |
| ispartof | Postȩpy higieny i medycyny doświadczalnej, 2012-09, Vol.66, p.592-602 |
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| language | eng |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals |
| subjects | Animals Antineoplastic Agents, Alkylating - adverse effects Chemoprevention Cyclophosphamide - adverse effects Cyclophosphamide - pharmacology Cystitis - chemically induced Cystitis - prevention & control Cytoprotection Hemorrhage - chemically induced Hemorrhage - prevention & control Humans Ifosfamide - adverse effects Protective Agents - therapeutic use Urinary Bladder - drug effects |
| title | Bladder urotoxicity pathophysiology induced by the oxazaphosphorine alkylating agents and its chemoprevention |
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