A docetaxel-carboxymethylcellulose nanoparticle outperforms the approved taxane nanoformulation, Abraxane, in mouse tumor models with significant control of metastases

Cellax is a PEGylated carboxymethylcellulose conjugate of docetaxel (DTX) which condenses into a 120-nm nanoparticle, and was compared against the approved clinical taxane nanoformulation (Abraxane®) in mouse models. Cellax increased the systemic exposure of taxanes by 37× compared to Abraxane, and...

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Veröffentlicht in:	Journal of controlled release 2012-09, Vol.162 (3), p.575-581
Hauptverfasser:	Ernsting, Mark J., Murakami, Mami, Undzys, Elijus, Aman, Ahmed, Press, Barry, Li, Shyh-Dar
Format:	Artikel
Sprache:	eng
Schlagworte:	Abraxane Albumin-Bound Paclitaxel Albumins - administration & dosage Albumins - pharmacokinetics animal models Animals Antineoplastic Agents - administration & dosage Antineoplastic Agents - pharmacokinetics Biological and medical sciences breast neoplasms Carboxymethylcellulose Carboxymethylcellulose Sodium - administration & dosage Carboxymethylcellulose Sodium - pharmacokinetics Cell Line, Tumor Delayed-Action Preparations - administration & dosage Delayed-Action Preparations - pharmacokinetics Docetaxel Drug delivery drugs Female General pharmacology Humans inhibitory concentration 50 kidneys liver Male Medical sciences melanoma metastasis Mice Mice, Inbred BALB C Mice, Inbred C57BL Mice, SCID nanomedicine Nanoparticles Nanoparticles - administration & dosage Neoplasms - drug therapy Neoplasms - pathology Paclitaxel Paclitaxel - administration & dosage Paclitaxel - pharmacokinetics Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments spleen taxanes Taxoids - administration & dosage Taxoids - pharmacokinetics tissues Tumor Burden - drug effects Xenograft Model Antitumor Assays
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