Different PI 3-kinase inhibitors have distinct effects on endothelial permeability and leukocyte transmigration

Endothelial cells play a central role in inflammatory responses, mediating leukocyte and solute traffic from blood vessels into the tissue, and are therefore key targets for anti-inflammatory therapies. Phosphoinositide 3-kinases (PI3Ks) are important signal transducers in inflammation and cancer, h...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	The international journal of biochemistry & cell biology 2012-11, Vol.44 (11), p.1929-1936
Hauptverfasser:	Cain, Robert J., Vanhaesebroeck, Bart, Ridley, Anne J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenine - analogs & derivatives Adenine - pharmacology Androstadienes - pharmacology Antigens, CD - metabolism blood vessels Cadherins - metabolism Capillary Permeability - drug effects Cell Membrane Permeability - drug effects Cell Shape - drug effects Class Ia Phosphatidylinositol 3-Kinase - metabolism Dioxoles - pharmacology endothelial cells Endothelial Cells - cytology Endothelial Cells - drug effects Endothelial Cells - enzymology Endothelium Focal Adhesion Kinase 2 - metabolism Furans - pharmacology Human Umbilical Vein Endothelial Cells - cytology Human Umbilical Vein Endothelial Cells - drug effects Human Umbilical Vein Endothelial Cells - metabolism Humans inflammation leukocytes Leukocytes - cytology Leukocytes - drug effects Leukocytes - metabolism Permeability phosphatidylinositol 3-kinase Phosphatidylinositol 3-Kinases - metabolism Phosphoinositide-3 Kinase Inhibitors Phosphorylation - drug effects PI3K PI3K inhibitors Protein Binding - drug effects Protein Kinase Inhibitors - pharmacology Proto-Oncogene Proteins c-akt - metabolism Pyridines - pharmacology Pyrimidines - pharmacology Quinazolines - pharmacology signal transduction Signal Transduction - drug effects solutes Thiazolidinediones - pharmacology TOR Serine-Threonine Kinases - metabolism Transendothelial and Transepithelial Migration - drug effects Transendothelial migration transmission electron microscopy tumor necrosis factor-alpha Tumor Necrosis Factor-alpha - pharmacology tyrosine Wortmannin
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!