Androgen-responsive and nonresponsive prostate cancer cells present a distinct glycolytic metabolism profile

Prostate cancer (PCa) progresses from an early stage, confined to prostate, to a more aggressive metastasized cancer related with loss of androgen responsiveness. Although, it has been recognized that PCa cells have unique metabolic features, their glycolytic profile in androgen-dependent and androg...

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Veröffentlicht in:	The international journal of biochemistry & cell biology 2012-11, Vol.44 (11), p.2077-2084
Hauptverfasser:	Vaz, Cátia V., Alves, Marco G., Marques, Ricardo, Moreira, Paula I., Oliveira, Pedro F., Maia, Cláudio J., Socorro, Sílvia
Format:	Artikel
Sprache:	eng
Schlagworte:	alanine Alanine - biosynthesis Androgen Androgens - pharmacology biochemical pathways cell culture Cell Line, Tumor culture media Gene Expression Regulation, Neoplastic - drug effects glucose Glucose - metabolism Glucose Transporter Type 1 - genetics Glucose Transporter Type 1 - metabolism Glucose Transporter Type 3 - genetics Glucose Transporter Type 3 - metabolism glucose transporters glycolysis Glycolysis - drug effects Humans L-Lactate Dehydrogenase - metabolism lactate dehydrogenase Lactic Acid - biosynthesis LnCap Male messenger RNA Metabolome - drug effects Metabolomics Models, Biological Monocarboxylic Acid Transporters - genetics Monocarboxylic Acid Transporters - metabolism Muscle Proteins - genetics Muscle Proteins - metabolism neoplasm cells NMR nuclear magnetic resonance spectroscopy oxidative stress PC3 Phosphofructokinase-1 - genetics Phosphofructokinase-1 - metabolism phosphofructokinases prostatic neoplasms Prostatic Neoplasms - enzymology Prostatic Neoplasms - metabolism Prostatic Neoplasms - pathology protein synthesis quantitative polymerase chain reaction RNA, Messenger - genetics RNA, Messenger - metabolism Western blotting
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