Clinicopathological correlation of cutaneous metastatic breast carcinoma using lymphatic and vascular markers: lymphatics are mainly involved in cutaneous metastasis
Summary Precise clinicopathological correlations of the clinical features of metastatic breast carcinoma with lymphatic‐specific markers are rare. We classified 28 patients with metastatic breast carcinoma according to their clinical features. Immunohistochemical staining was performed using D2‐40,...
Gespeichert in:
| Veröffentlicht in: | Clinical and experimental dermatology 2012-10, Vol.37 (7), p.744-748 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 748 |
|---|---|
| container_issue | 7 |
| container_start_page | 744 |
| container_title | Clinical and experimental dermatology |
| container_volume | 37 |
| creator | Yun, S. J. Park, H. Y. Lee, J. S. Park, M. H. Lee, J. B. Won, Y. H. |
| description | Summary
Precise clinicopathological correlations of the clinical features of metastatic breast carcinoma with lymphatic‐specific markers are rare. We classified 28 patients with metastatic breast carcinoma according to their clinical features. Immunohistochemical staining was performed using D2‐40, CD31 and CD34. Of the 28 patients, 8 (28.6%) had inflammatory metastatic carcinoma, 6 (21.4%) had the telangiectatic type, 5 had the nodular type, 3 had the en cuirasse type, 3 had alopecia neoplastica, and 3 had a combination of features. D2‐40 staining revealed dilated lymphatic channels (lymphangiectasia) in the upper dermis of all patients; in addition, 13 patients (46.4%) had intralymphatic tumour‐cell emboli, which were common in those with the inflammatory and telangiectatic types. Intratumoral lymphatic invasion in the main tumour nodule was seen in 12 patients (42.9%). Our results suggest that cutaneous metastatic breast carcinomas have various clinical presentations, and that lymphatic vessels play an important role in all types of cutaneous metastasis. |
| doi_str_mv | 10.1111/j.1365-2230.2011.04306.x |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_proquest_miscellaneous_1074763108</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1074763108</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4166-cc54038ac0107fa46239a2acfe1521d4e0b20459ec67e30134b65e4f00fd60123</originalsourceid><addsrcrecordid>eNplks9uEzEQxi0EoqHwCsgSQuKyy_jP2hskDigtLajAARDcLMfrbR2862DvhuSBeE-8TUgl8MUjf7_5PJoZhDCBkuTzclUSJqqCUgYlBUJK4AxEub2HZkfhPpoBA1mIOatP0KOUVgCEEVk9RCdZp3NJ5Qz9XnjXOxPWergJPlw7oz02IUbr9eBCj0OLzTjo3oYx4c4OOg1ZMHgZbQ6x0dG4PnQaj8n119jvuvXNLaD7Bm90MqPXEXc6_rAxvbrTE9bR5nfX-x12_Sb4jW1y8P9vyaXH6EGrfbJPDvcp-vr2_Mvisrj6dPFu8eaqMJwIURhTcWC1NkBAtpoLyuaaatNaUlHScAtLCryaWyOkZbkbfCkqy1uAthFAKDtFL_a-6xh-jjYNqnPJWO_3Falsy6VgBOqMPvsHXYUx9rk6RSpe1axmcp6ppwdqXHa2Uevocit26u8AMvD8AORWad9G3RuX7jjBc2FcZO71nvvlvN0ddQJqWgi1UtPcJ1tQ00Ko24VQW7U4P5uinF_s810a7PaYn8eihGSyUt8-XijyuT67_P7-g6rZHwb2uxU</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1545838379</pqid></control><display><type>article</type><title>Clinicopathological correlation of cutaneous metastatic breast carcinoma using lymphatic and vascular markers: lymphatics are mainly involved in cutaneous metastasis</title><source>MEDLINE</source><source>Oxford University Press Journals All Titles (1996-Current)</source><source>Alma/SFX Local Collection</source><creator>Yun, S. J. ; Park, H. Y. ; Lee, J. S. ; Park, M. H. ; Lee, J. B. ; Won, Y. H.</creator><creatorcontrib>Yun, S. J. ; Park, H. Y. ; Lee, J. S. ; Park, M. H. ; Lee, J. B. ; Won, Y. H.</creatorcontrib><description>Summary
Precise clinicopathological correlations of the clinical features of metastatic breast carcinoma with lymphatic‐specific markers are rare. We classified 28 patients with metastatic breast carcinoma according to their clinical features. Immunohistochemical staining was performed using D2‐40, CD31 and CD34. Of the 28 patients, 8 (28.6%) had inflammatory metastatic carcinoma, 6 (21.4%) had the telangiectatic type, 5 had the nodular type, 3 had the en cuirasse type, 3 had alopecia neoplastica, and 3 had a combination of features. D2‐40 staining revealed dilated lymphatic channels (lymphangiectasia) in the upper dermis of all patients; in addition, 13 patients (46.4%) had intralymphatic tumour‐cell emboli, which were common in those with the inflammatory and telangiectatic types. Intratumoral lymphatic invasion in the main tumour nodule was seen in 12 patients (42.9%). Our results suggest that cutaneous metastatic breast carcinomas have various clinical presentations, and that lymphatic vessels play an important role in all types of cutaneous metastasis.</description><identifier>ISSN: 0307-6938</identifier><identifier>EISSN: 1365-2230</identifier><identifier>DOI: 10.1111/j.1365-2230.2011.04306.x</identifier><identifier>PMID: 22329727</identifier><identifier>CODEN: CEDEDE</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Adult ; Aged ; Biological and medical sciences ; Biomarkers, Tumor - metabolism ; Breast cancer ; Breast Neoplasms - pathology ; Carcinoma, Ductal, Breast - metabolism ; Carcinoma, Ductal, Breast - pathology ; Carcinoma, Ductal, Breast - secondary ; Dermatology ; Female ; Gynecology. Andrology. Obstetrics ; Humans ; Immunohistochemistry ; Lymphatic Metastasis ; Lymphatic system ; Lymphatic Vessels - pathology ; Mammary gland diseases ; Medical sciences ; Metastasis ; Middle Aged ; Skin Neoplasms - metabolism ; Skin Neoplasms - secondary ; Tumors ; Tumors of the skin and soft tissue. Premalignant lesions</subject><ispartof>Clinical and experimental dermatology, 2012-10, Vol.37 (7), p.744-748</ispartof><rights>The Author(s). CED © 2012 British Association of Dermatologists</rights><rights>2015 INIST-CNRS</rights><rights>The Author(s). CED © 2012 British Association of Dermatologists.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4166-cc54038ac0107fa46239a2acfe1521d4e0b20459ec67e30134b65e4f00fd60123</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=26460146$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22329727$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yun, S. J.</creatorcontrib><creatorcontrib>Park, H. Y.</creatorcontrib><creatorcontrib>Lee, J. S.</creatorcontrib><creatorcontrib>Park, M. H.</creatorcontrib><creatorcontrib>Lee, J. B.</creatorcontrib><creatorcontrib>Won, Y. H.</creatorcontrib><title>Clinicopathological correlation of cutaneous metastatic breast carcinoma using lymphatic and vascular markers: lymphatics are mainly involved in cutaneous metastasis</title><title>Clinical and experimental dermatology</title><addtitle>Clin Exp Dermatol</addtitle><description>Summary
Precise clinicopathological correlations of the clinical features of metastatic breast carcinoma with lymphatic‐specific markers are rare. We classified 28 patients with metastatic breast carcinoma according to their clinical features. Immunohistochemical staining was performed using D2‐40, CD31 and CD34. Of the 28 patients, 8 (28.6%) had inflammatory metastatic carcinoma, 6 (21.4%) had the telangiectatic type, 5 had the nodular type, 3 had the en cuirasse type, 3 had alopecia neoplastica, and 3 had a combination of features. D2‐40 staining revealed dilated lymphatic channels (lymphangiectasia) in the upper dermis of all patients; in addition, 13 patients (46.4%) had intralymphatic tumour‐cell emboli, which were common in those with the inflammatory and telangiectatic types. Intratumoral lymphatic invasion in the main tumour nodule was seen in 12 patients (42.9%). Our results suggest that cutaneous metastatic breast carcinomas have various clinical presentations, and that lymphatic vessels play an important role in all types of cutaneous metastasis.</description><subject>Adult</subject><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Biomarkers, Tumor - metabolism</subject><subject>Breast cancer</subject><subject>Breast Neoplasms - pathology</subject><subject>Carcinoma, Ductal, Breast - metabolism</subject><subject>Carcinoma, Ductal, Breast - pathology</subject><subject>Carcinoma, Ductal, Breast - secondary</subject><subject>Dermatology</subject><subject>Female</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Lymphatic Metastasis</subject><subject>Lymphatic system</subject><subject>Lymphatic Vessels - pathology</subject><subject>Mammary gland diseases</subject><subject>Medical sciences</subject><subject>Metastasis</subject><subject>Middle Aged</subject><subject>Skin Neoplasms - metabolism</subject><subject>Skin Neoplasms - secondary</subject><subject>Tumors</subject><subject>Tumors of the skin and soft tissue. Premalignant lesions</subject><issn>0307-6938</issn><issn>1365-2230</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNplks9uEzEQxi0EoqHwCsgSQuKyy_jP2hskDigtLajAARDcLMfrbR2862DvhuSBeE-8TUgl8MUjf7_5PJoZhDCBkuTzclUSJqqCUgYlBUJK4AxEub2HZkfhPpoBA1mIOatP0KOUVgCEEVk9RCdZp3NJ5Qz9XnjXOxPWergJPlw7oz02IUbr9eBCj0OLzTjo3oYx4c4OOg1ZMHgZbQ6x0dG4PnQaj8n119jvuvXNLaD7Bm90MqPXEXc6_rAxvbrTE9bR5nfX-x12_Sb4jW1y8P9vyaXH6EGrfbJPDvcp-vr2_Mvisrj6dPFu8eaqMJwIURhTcWC1NkBAtpoLyuaaatNaUlHScAtLCryaWyOkZbkbfCkqy1uAthFAKDtFL_a-6xh-jjYNqnPJWO_3Falsy6VgBOqMPvsHXYUx9rk6RSpe1axmcp6ppwdqXHa2Uevocit26u8AMvD8AORWad9G3RuX7jjBc2FcZO71nvvlvN0ddQJqWgi1UtPcJ1tQ00Ko24VQW7U4P5uinF_s810a7PaYn8eihGSyUt8-XijyuT67_P7-g6rZHwb2uxU</recordid><startdate>201210</startdate><enddate>201210</enddate><creator>Yun, S. J.</creator><creator>Park, H. Y.</creator><creator>Lee, J. S.</creator><creator>Park, M. H.</creator><creator>Lee, J. B.</creator><creator>Won, Y. H.</creator><general>Blackwell Publishing Ltd</general><general>Wiley-Blackwell</general><general>Oxford University Press</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7T5</scope><scope>H94</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>201210</creationdate><title>Clinicopathological correlation of cutaneous metastatic breast carcinoma using lymphatic and vascular markers: lymphatics are mainly involved in cutaneous metastasis</title><author>Yun, S. J. ; Park, H. Y. ; Lee, J. S. ; Park, M. H. ; Lee, J. B. ; Won, Y. H.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4166-cc54038ac0107fa46239a2acfe1521d4e0b20459ec67e30134b65e4f00fd60123</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Biomarkers, Tumor - metabolism</topic><topic>Breast cancer</topic><topic>Breast Neoplasms - pathology</topic><topic>Carcinoma, Ductal, Breast - metabolism</topic><topic>Carcinoma, Ductal, Breast - pathology</topic><topic>Carcinoma, Ductal, Breast - secondary</topic><topic>Dermatology</topic><topic>Female</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Lymphatic Metastasis</topic><topic>Lymphatic system</topic><topic>Lymphatic Vessels - pathology</topic><topic>Mammary gland diseases</topic><topic>Medical sciences</topic><topic>Metastasis</topic><topic>Middle Aged</topic><topic>Skin Neoplasms - metabolism</topic><topic>Skin Neoplasms - secondary</topic><topic>Tumors</topic><topic>Tumors of the skin and soft tissue. Premalignant lesions</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yun, S. J.</creatorcontrib><creatorcontrib>Park, H. Y.</creatorcontrib><creatorcontrib>Lee, J. S.</creatorcontrib><creatorcontrib>Park, M. H.</creatorcontrib><creatorcontrib>Lee, J. B.</creatorcontrib><creatorcontrib>Won, Y. H.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical and experimental dermatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yun, S. J.</au><au>Park, H. Y.</au><au>Lee, J. S.</au><au>Park, M. H.</au><au>Lee, J. B.</au><au>Won, Y. H.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Clinicopathological correlation of cutaneous metastatic breast carcinoma using lymphatic and vascular markers: lymphatics are mainly involved in cutaneous metastasis</atitle><jtitle>Clinical and experimental dermatology</jtitle><addtitle>Clin Exp Dermatol</addtitle><date>2012-10</date><risdate>2012</risdate><volume>37</volume><issue>7</issue><spage>744</spage><epage>748</epage><pages>744-748</pages><issn>0307-6938</issn><eissn>1365-2230</eissn><coden>CEDEDE</coden><abstract>Summary
Precise clinicopathological correlations of the clinical features of metastatic breast carcinoma with lymphatic‐specific markers are rare. We classified 28 patients with metastatic breast carcinoma according to their clinical features. Immunohistochemical staining was performed using D2‐40, CD31 and CD34. Of the 28 patients, 8 (28.6%) had inflammatory metastatic carcinoma, 6 (21.4%) had the telangiectatic type, 5 had the nodular type, 3 had the en cuirasse type, 3 had alopecia neoplastica, and 3 had a combination of features. D2‐40 staining revealed dilated lymphatic channels (lymphangiectasia) in the upper dermis of all patients; in addition, 13 patients (46.4%) had intralymphatic tumour‐cell emboli, which were common in those with the inflammatory and telangiectatic types. Intratumoral lymphatic invasion in the main tumour nodule was seen in 12 patients (42.9%). Our results suggest that cutaneous metastatic breast carcinomas have various clinical presentations, and that lymphatic vessels play an important role in all types of cutaneous metastasis.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>22329727</pmid><doi>10.1111/j.1365-2230.2011.04306.x</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0307-6938 |
| ispartof | Clinical and experimental dermatology, 2012-10, Vol.37 (7), p.744-748 |
| issn | 0307-6938 1365-2230 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1074763108 |
| source | MEDLINE; Oxford University Press Journals All Titles (1996-Current); Alma/SFX Local Collection |
| subjects | Adult Aged Biological and medical sciences Biomarkers, Tumor - metabolism Breast cancer Breast Neoplasms - pathology Carcinoma, Ductal, Breast - metabolism Carcinoma, Ductal, Breast - pathology Carcinoma, Ductal, Breast - secondary Dermatology Female Gynecology. Andrology. Obstetrics Humans Immunohistochemistry Lymphatic Metastasis Lymphatic system Lymphatic Vessels - pathology Mammary gland diseases Medical sciences Metastasis Middle Aged Skin Neoplasms - metabolism Skin Neoplasms - secondary Tumors Tumors of the skin and soft tissue. Premalignant lesions |
| title | Clinicopathological correlation of cutaneous metastatic breast carcinoma using lymphatic and vascular markers: lymphatics are mainly involved in cutaneous metastasis |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-07T10%3A00%3A18IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Clinicopathological%20correlation%20of%20cutaneous%20metastatic%20breast%20carcinoma%20using%20lymphatic%20and%20vascular%20markers:%20lymphatics%20are%20mainly%20involved%20in%20cutaneous%20metastasis&rft.jtitle=Clinical%20and%20experimental%20dermatology&rft.au=Yun,%20S.%20J.&rft.date=2012-10&rft.volume=37&rft.issue=7&rft.spage=744&rft.epage=748&rft.pages=744-748&rft.issn=0307-6938&rft.eissn=1365-2230&rft.coden=CEDEDE&rft_id=info:doi/10.1111/j.1365-2230.2011.04306.x&rft_dat=%3Cproquest_pubme%3E1074763108%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1545838379&rft_id=info:pmid/22329727&rfr_iscdi=true |