Isocitrate dehydrogenase 1 and 2 mutations in cholangiocarcinoma

Summary Somatic mutations in isocitrate dehydrogenase 1 and 2 genes are common in gliomas and help stratify patients with brain cancer into histologic and molecular subtypes. However, these mutations are considered rare in other solid tumors. The aims of this study were to determine the frequency of...

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Veröffentlicht in:	Human pathology 2012-10, Vol.43 (10), p.1552-1558
Hauptverfasser:	Kipp, Benjamin R., PhD, Voss, Jesse S., BS, CT, MB(ASCP), Kerr, Sarah E., MD, Barr Fritcher, Emily G., BA, CT, MB(ASCP), Graham, Rondell P., MBBS, Zhang, Lizhi, MD, Highsmith, W. Edward, PhD, Zhang, Jun, MD, Roberts, Lewis R., MB, ChB, PhD, Gores, Gregory J., MD, Halling, Kevin C., MD, PhD
Format:	Artikel
Sprache:	eng
Schlagworte:	2-hydroxyglutarate Base Sequence Bile duct Bile Duct Neoplasms - genetics Bile Duct Neoplasms - pathology Bile Ducts, Intrahepatic - pathology Biliary tract Biological and medical sciences Cancer Cholangiocarcinoma Cholangiocarcinoma - genetics Cholangiocarcinoma - pathology Female Gastroenterology. Liver. Pancreas. Abdomen Genes Humans Investigative techniques, diagnostic techniques (general aspects) Isocitrate dehydrogenase Isocitrate Dehydrogenase - genetics Liver. Biliary tract. Portal circulation. Exocrine pancreas Male Medical sciences Middle Aged Mutation Pathology Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Reverse Transcriptase Polymerase Chain Reaction Studies Tumors
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