OX40 signaling favors the induction of T(H)9 cells and airway inflammation

The mechanisms that regulate the T(H)9 subset of helper T cells and diseases mediated by T(H)9 cells remain poorly defined. Here we found that the costimulatory receptor OX40 was a powerful inducer of T(H)9 cells in vitro and T(H)9 cell-dependent airway inflammation in vivo. In polarizing conditions...

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Veröffentlicht in:	Nature immunology 2012-10, Vol.13 (10), p.981-990
Hauptverfasser:	Xiao, Xiang, Balasubramanian, Savithri, Liu, Wentao, Chu, Xiufeng, Wang, Haibin, Taparowsky, Elizabeth J, Fu, Yang-Xin, Choi, Yongwon, Walsh, Matthew C, Li, Xian Chang
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals CD4 Antigens - biosynthesis Humans Inflammation - immunology Inflammation - metabolism Interleukin-9 - biosynthesis Interleukin-9 - metabolism Mice NF-kappa B - metabolism NF-kappaB-Inducing Kinase OX40 Ligand - immunology OX40 Ligand - metabolism Protein Serine-Threonine Kinases - biosynthesis Protein Serine-Threonine Kinases - metabolism Proto-Oncogene Proteins - immunology Proto-Oncogene Proteins - metabolism Receptors, OX40 - immunology Receptors, OX40 - metabolism Respiratory System - immunology Signal Transduction - immunology T-Lymphocytes, Helper-Inducer - immunology T-Lymphocytes, Helper-Inducer - metabolism TNF Receptor-Associated Factor 6 - biosynthesis TNF Receptor-Associated Factor 6 - metabolism Trans-Activators - immunology Trans-Activators - metabolism Transforming Growth Factor beta - immunology Transforming Growth Factor beta - metabolism
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