Cutaneous metastasis as a initial presentation in advanced non-small cell lung cancer and its poor survival prognosis
Aim Cutaneous metastases in primary advanced non-small cell lung cancer (NSCLC) rarely occur in comparison with other site involvement. The incidence of cutaneous metastases and its prognosis is not well known. Data from a 2,130 patients with advanced NSCLC were analyzed, in order to assess the inci...
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| Veröffentlicht in: | Journal of cancer research and clinical oncology 2012-10, Vol.138 (10), p.1613-1617 |
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| container_title | Journal of cancer research and clinical oncology |
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| creator | Song, Zhengbo Lin, Baochai Shao, Lan Zhang, Yiping |
| description | Aim
Cutaneous metastases in primary advanced non-small cell lung cancer (NSCLC) rarely occur in comparison with other site involvement. The incidence of cutaneous metastases and its prognosis is not well known. Data from a 2,130 patients with advanced NSCLC were analyzed, in order to assess the incidence and survival prognosis of cutaneous metastases in primary advanced NSCLC.
Methods
The clinical data of 2,130 patients with advanced NSCLC who were admitted to Zhejiang cancer Hospital from January 1998 to December 2007 were retrospectively analyzed. Data pertaining to their presentation, diagnosis treatment, pathology, follow–up, and clinical course were documented. Clinical characteristics were investigated based on the clinical and pathologic records. All of the cutaneous metastases were confirmed by cytology or biopsy. Survival analysis was made by Kaplan–Meier method. The Cox regression model was performed to analyze the relationship between the influential factors and the overall survival.
Results
Among the 2,130 advanced NSCLC patients as initial diagnosis, 60 (2.8 %) demonstrated abnormally cutaneous metastases. Fifteen patients with only cutaneous metastases, forty-five subjects combined with other site metastasis. There were 56 patients who received chemotherapy, and the first-line disease control rate was 33.9 %, the median free progression survival time was 1.9 months. There were significant differences in overall survival between cutaneous metastases and non-cutaneous metastases arms (3.9 vs. 10.0 months,
P
|
| doi_str_mv | 10.1007/s00432-012-1239-6 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1069208409</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1069208409</sourcerecordid><originalsourceid>FETCH-LOGICAL-c402t-5a596a58964011b830147cc662dc3e4849de41b13162431ebce2e54b7fb623c83</originalsourceid><addsrcrecordid>eNp1kV2L1TAQhoMo7tnVH-CNBETYm2omX20v5eAXLHij1yVNcw5Z2uSYaQ_473dqjx8IwpCQyTPzTvIy9gLEGxCifotCaCUrAbICqdrKPmI7WDOglHnMdgJqqIwEe8WuEe8FnU0tn7IrKU0D0qodW_bL7FLIC_IpzA4pInJHwWOKc3QjP5WAIc1ujjlRkrvh7JIPA085VTi5ceQ-0DIu6cj9elW4SwOPM_JTzoXjUs7x_LNTPqZMAs_Yk4MbMTy_7Dfs24f3X_efqrsvHz_v391VXgs5V8aZ1jrTtFYLgL5RAnTtvbVy8CroRrdD0NCDAiu1gtD7IIPRfX3orVS-UTfsdutLyt-XgHM3RVyH3Z7cgbCtFI0WLaGv_kHv81ISTUeUJgndtjVRsFG-ZMQSDt2pxMmVHwR1qyfd5klHnnSrJ52lmpeXzks_heF3xS8TCHh9ARx6Nx4K_WHEP5zVq6mGOLlxSFfpGMrfI_5P_QHSj6OU</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1041314997</pqid></control><display><type>article</type><title>Cutaneous metastasis as a initial presentation in advanced non-small cell lung cancer and its poor survival prognosis</title><source>MEDLINE</source><source>Springer Nature - Complete Springer Journals</source><creator>Song, Zhengbo ; Lin, Baochai ; Shao, Lan ; Zhang, Yiping</creator><creatorcontrib>Song, Zhengbo ; Lin, Baochai ; Shao, Lan ; Zhang, Yiping</creatorcontrib><description>Aim
Cutaneous metastases in primary advanced non-small cell lung cancer (NSCLC) rarely occur in comparison with other site involvement. The incidence of cutaneous metastases and its prognosis is not well known. Data from a 2,130 patients with advanced NSCLC were analyzed, in order to assess the incidence and survival prognosis of cutaneous metastases in primary advanced NSCLC.
Methods
The clinical data of 2,130 patients with advanced NSCLC who were admitted to Zhejiang cancer Hospital from January 1998 to December 2007 were retrospectively analyzed. Data pertaining to their presentation, diagnosis treatment, pathology, follow–up, and clinical course were documented. Clinical characteristics were investigated based on the clinical and pathologic records. All of the cutaneous metastases were confirmed by cytology or biopsy. Survival analysis was made by Kaplan–Meier method. The Cox regression model was performed to analyze the relationship between the influential factors and the overall survival.
Results
Among the 2,130 advanced NSCLC patients as initial diagnosis, 60 (2.8 %) demonstrated abnormally cutaneous metastases. Fifteen patients with only cutaneous metastases, forty-five subjects combined with other site metastasis. There were 56 patients who received chemotherapy, and the first-line disease control rate was 33.9 %, the median free progression survival time was 1.9 months. There were significant differences in overall survival between cutaneous metastases and non-cutaneous metastases arms (3.9 vs. 10.0 months,
P
< 0.001). Multivariate analyses revealed that performance status and chemotherapy efficacy statistically associated with overall survival.
Conclusions
This retrospective study indicated that 2.8 % of advanced NSCLC patients showed cutaneous metastases as an initial presentation. Cutaneous metastases of lung cancer are of poor prognosis.</description><identifier>ISSN: 0171-5216</identifier><identifier>EISSN: 1432-1335</identifier><identifier>DOI: 10.1007/s00432-012-1239-6</identifier><identifier>PMID: 22581263</identifier><identifier>CODEN: JCROD7</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer-Verlag</publisher><subject>Adult ; Aged ; Antineoplastic agents ; Biological and medical sciences ; Biopsy ; Cancer Research ; Carcinoma, Non-Small-Cell Lung - diagnosis ; Carcinoma, Non-Small-Cell Lung - drug therapy ; Carcinoma, Non-Small-Cell Lung - epidemiology ; Carcinoma, Non-Small-Cell Lung - pathology ; Chemotherapy ; China - epidemiology ; Dermatology ; Disease-Free Survival ; Female ; Follow-Up Studies ; Hematology ; Humans ; Incidence ; Internal Medicine ; Lung cancer ; Lung Neoplasms - diagnosis ; Lung Neoplasms - drug therapy ; Lung Neoplasms - epidemiology ; Lung Neoplasms - pathology ; Male ; Medical prognosis ; Medical sciences ; Medicine ; Medicine & Public Health ; Metastasis ; Middle Aged ; Oncology ; Original Paper ; Pharmacology. Drug treatments ; Pneumology ; Prognosis ; Retrospective Studies ; Skin cancer ; Skin Neoplasms - diagnosis ; Skin Neoplasms - drug therapy ; Skin Neoplasms - epidemiology ; Skin Neoplasms - pathology ; Skin Neoplasms - secondary ; Survival Analysis ; Tumors of the respiratory system and mediastinum ; Tumors of the skin and soft tissue. Premalignant lesions ; Young Adult</subject><ispartof>Journal of cancer research and clinical oncology, 2012-10, Vol.138 (10), p.1613-1617</ispartof><rights>Springer-Verlag 2012</rights><rights>2015 INIST-CNRS</rights><rights>Springer-Verlag Berlin Heidelberg 2012</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c402t-5a596a58964011b830147cc662dc3e4849de41b13162431ebce2e54b7fb623c83</citedby><cites>FETCH-LOGICAL-c402t-5a596a58964011b830147cc662dc3e4849de41b13162431ebce2e54b7fb623c83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00432-012-1239-6$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00432-012-1239-6$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=26414325$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22581263$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Song, Zhengbo</creatorcontrib><creatorcontrib>Lin, Baochai</creatorcontrib><creatorcontrib>Shao, Lan</creatorcontrib><creatorcontrib>Zhang, Yiping</creatorcontrib><title>Cutaneous metastasis as a initial presentation in advanced non-small cell lung cancer and its poor survival prognosis</title><title>Journal of cancer research and clinical oncology</title><addtitle>J Cancer Res Clin Oncol</addtitle><addtitle>J Cancer Res Clin Oncol</addtitle><description>Aim
Cutaneous metastases in primary advanced non-small cell lung cancer (NSCLC) rarely occur in comparison with other site involvement. The incidence of cutaneous metastases and its prognosis is not well known. Data from a 2,130 patients with advanced NSCLC were analyzed, in order to assess the incidence and survival prognosis of cutaneous metastases in primary advanced NSCLC.
Methods
The clinical data of 2,130 patients with advanced NSCLC who were admitted to Zhejiang cancer Hospital from January 1998 to December 2007 were retrospectively analyzed. Data pertaining to their presentation, diagnosis treatment, pathology, follow–up, and clinical course were documented. Clinical characteristics were investigated based on the clinical and pathologic records. All of the cutaneous metastases were confirmed by cytology or biopsy. Survival analysis was made by Kaplan–Meier method. The Cox regression model was performed to analyze the relationship between the influential factors and the overall survival.
Results
Among the 2,130 advanced NSCLC patients as initial diagnosis, 60 (2.8 %) demonstrated abnormally cutaneous metastases. Fifteen patients with only cutaneous metastases, forty-five subjects combined with other site metastasis. There were 56 patients who received chemotherapy, and the first-line disease control rate was 33.9 %, the median free progression survival time was 1.9 months. There were significant differences in overall survival between cutaneous metastases and non-cutaneous metastases arms (3.9 vs. 10.0 months,
P
< 0.001). Multivariate analyses revealed that performance status and chemotherapy efficacy statistically associated with overall survival.
Conclusions
This retrospective study indicated that 2.8 % of advanced NSCLC patients showed cutaneous metastases as an initial presentation. Cutaneous metastases of lung cancer are of poor prognosis.</description><subject>Adult</subject><subject>Aged</subject><subject>Antineoplastic agents</subject><subject>Biological and medical sciences</subject><subject>Biopsy</subject><subject>Cancer Research</subject><subject>Carcinoma, Non-Small-Cell Lung - diagnosis</subject><subject>Carcinoma, Non-Small-Cell Lung - drug therapy</subject><subject>Carcinoma, Non-Small-Cell Lung - epidemiology</subject><subject>Carcinoma, Non-Small-Cell Lung - pathology</subject><subject>Chemotherapy</subject><subject>China - epidemiology</subject><subject>Dermatology</subject><subject>Disease-Free Survival</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Hematology</subject><subject>Humans</subject><subject>Incidence</subject><subject>Internal Medicine</subject><subject>Lung cancer</subject><subject>Lung Neoplasms - diagnosis</subject><subject>Lung Neoplasms - drug therapy</subject><subject>Lung Neoplasms - epidemiology</subject><subject>Lung Neoplasms - pathology</subject><subject>Male</subject><subject>Medical prognosis</subject><subject>Medical sciences</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Metastasis</subject><subject>Middle Aged</subject><subject>Oncology</subject><subject>Original Paper</subject><subject>Pharmacology. Drug treatments</subject><subject>Pneumology</subject><subject>Prognosis</subject><subject>Retrospective Studies</subject><subject>Skin cancer</subject><subject>Skin Neoplasms - diagnosis</subject><subject>Skin Neoplasms - drug therapy</subject><subject>Skin Neoplasms - epidemiology</subject><subject>Skin Neoplasms - pathology</subject><subject>Skin Neoplasms - secondary</subject><subject>Survival Analysis</subject><subject>Tumors of the respiratory system and mediastinum</subject><subject>Tumors of the skin and soft tissue. Premalignant lesions</subject><subject>Young Adult</subject><issn>0171-5216</issn><issn>1432-1335</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp1kV2L1TAQhoMo7tnVH-CNBETYm2omX20v5eAXLHij1yVNcw5Z2uSYaQ_473dqjx8IwpCQyTPzTvIy9gLEGxCifotCaCUrAbICqdrKPmI7WDOglHnMdgJqqIwEe8WuEe8FnU0tn7IrKU0D0qodW_bL7FLIC_IpzA4pInJHwWOKc3QjP5WAIc1ujjlRkrvh7JIPA085VTi5ceQ-0DIu6cj9elW4SwOPM_JTzoXjUs7x_LNTPqZMAs_Yk4MbMTy_7Dfs24f3X_efqrsvHz_v391VXgs5V8aZ1jrTtFYLgL5RAnTtvbVy8CroRrdD0NCDAiu1gtD7IIPRfX3orVS-UTfsdutLyt-XgHM3RVyH3Z7cgbCtFI0WLaGv_kHv81ISTUeUJgndtjVRsFG-ZMQSDt2pxMmVHwR1qyfd5klHnnSrJ52lmpeXzks_heF3xS8TCHh9ARx6Nx4K_WHEP5zVq6mGOLlxSFfpGMrfI_5P_QHSj6OU</recordid><startdate>20121001</startdate><enddate>20121001</enddate><creator>Song, Zhengbo</creator><creator>Lin, Baochai</creator><creator>Shao, Lan</creator><creator>Zhang, Yiping</creator><general>Springer-Verlag</general><general>Springer</general><general>Springer Nature B.V</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TO</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>PHGZM</scope><scope>PHGZT</scope><scope>PJZUB</scope><scope>PKEHL</scope><scope>PPXIY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20121001</creationdate><title>Cutaneous metastasis as a initial presentation in advanced non-small cell lung cancer and its poor survival prognosis</title><author>Song, Zhengbo ; Lin, Baochai ; Shao, Lan ; Zhang, Yiping</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c402t-5a596a58964011b830147cc662dc3e4849de41b13162431ebce2e54b7fb623c83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Antineoplastic agents</topic><topic>Biological and medical sciences</topic><topic>Biopsy</topic><topic>Cancer Research</topic><topic>Carcinoma, Non-Small-Cell Lung - diagnosis</topic><topic>Carcinoma, Non-Small-Cell Lung - drug therapy</topic><topic>Carcinoma, Non-Small-Cell Lung - epidemiology</topic><topic>Carcinoma, Non-Small-Cell Lung - pathology</topic><topic>Chemotherapy</topic><topic>China - epidemiology</topic><topic>Dermatology</topic><topic>Disease-Free Survival</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Hematology</topic><topic>Humans</topic><topic>Incidence</topic><topic>Internal Medicine</topic><topic>Lung cancer</topic><topic>Lung Neoplasms - diagnosis</topic><topic>Lung Neoplasms - drug therapy</topic><topic>Lung Neoplasms - epidemiology</topic><topic>Lung Neoplasms - pathology</topic><topic>Male</topic><topic>Medical prognosis</topic><topic>Medical sciences</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Metastasis</topic><topic>Middle Aged</topic><topic>Oncology</topic><topic>Original Paper</topic><topic>Pharmacology. Drug treatments</topic><topic>Pneumology</topic><topic>Prognosis</topic><topic>Retrospective Studies</topic><topic>Skin cancer</topic><topic>Skin Neoplasms - diagnosis</topic><topic>Skin Neoplasms - drug therapy</topic><topic>Skin Neoplasms - epidemiology</topic><topic>Skin Neoplasms - pathology</topic><topic>Skin Neoplasms - secondary</topic><topic>Survival Analysis</topic><topic>Tumors of the respiratory system and mediastinum</topic><topic>Tumors of the skin and soft tissue. Premalignant lesions</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Song, Zhengbo</creatorcontrib><creatorcontrib>Lin, Baochai</creatorcontrib><creatorcontrib>Shao, Lan</creatorcontrib><creatorcontrib>Zhang, Yiping</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>ProQuest Central (New)</collection><collection>ProQuest One Academic (New)</collection><collection>ProQuest Health & Medical Research Collection</collection><collection>ProQuest One Academic Middle East (New)</collection><collection>ProQuest One Health & Nursing</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of cancer research and clinical oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Song, Zhengbo</au><au>Lin, Baochai</au><au>Shao, Lan</au><au>Zhang, Yiping</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cutaneous metastasis as a initial presentation in advanced non-small cell lung cancer and its poor survival prognosis</atitle><jtitle>Journal of cancer research and clinical oncology</jtitle><stitle>J Cancer Res Clin Oncol</stitle><addtitle>J Cancer Res Clin Oncol</addtitle><date>2012-10-01</date><risdate>2012</risdate><volume>138</volume><issue>10</issue><spage>1613</spage><epage>1617</epage><pages>1613-1617</pages><issn>0171-5216</issn><eissn>1432-1335</eissn><coden>JCROD7</coden><abstract>Aim
Cutaneous metastases in primary advanced non-small cell lung cancer (NSCLC) rarely occur in comparison with other site involvement. The incidence of cutaneous metastases and its prognosis is not well known. Data from a 2,130 patients with advanced NSCLC were analyzed, in order to assess the incidence and survival prognosis of cutaneous metastases in primary advanced NSCLC.
Methods
The clinical data of 2,130 patients with advanced NSCLC who were admitted to Zhejiang cancer Hospital from January 1998 to December 2007 were retrospectively analyzed. Data pertaining to their presentation, diagnosis treatment, pathology, follow–up, and clinical course were documented. Clinical characteristics were investigated based on the clinical and pathologic records. All of the cutaneous metastases were confirmed by cytology or biopsy. Survival analysis was made by Kaplan–Meier method. The Cox regression model was performed to analyze the relationship between the influential factors and the overall survival.
Results
Among the 2,130 advanced NSCLC patients as initial diagnosis, 60 (2.8 %) demonstrated abnormally cutaneous metastases. Fifteen patients with only cutaneous metastases, forty-five subjects combined with other site metastasis. There were 56 patients who received chemotherapy, and the first-line disease control rate was 33.9 %, the median free progression survival time was 1.9 months. There were significant differences in overall survival between cutaneous metastases and non-cutaneous metastases arms (3.9 vs. 10.0 months,
P
< 0.001). Multivariate analyses revealed that performance status and chemotherapy efficacy statistically associated with overall survival.
Conclusions
This retrospective study indicated that 2.8 % of advanced NSCLC patients showed cutaneous metastases as an initial presentation. Cutaneous metastases of lung cancer are of poor prognosis.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer-Verlag</pub><pmid>22581263</pmid><doi>10.1007/s00432-012-1239-6</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0171-5216 |
| ispartof | Journal of cancer research and clinical oncology, 2012-10, Vol.138 (10), p.1613-1617 |
| issn | 0171-5216 1432-1335 |
| language | eng |
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| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Adult Aged Antineoplastic agents Biological and medical sciences Biopsy Cancer Research Carcinoma, Non-Small-Cell Lung - diagnosis Carcinoma, Non-Small-Cell Lung - drug therapy Carcinoma, Non-Small-Cell Lung - epidemiology Carcinoma, Non-Small-Cell Lung - pathology Chemotherapy China - epidemiology Dermatology Disease-Free Survival Female Follow-Up Studies Hematology Humans Incidence Internal Medicine Lung cancer Lung Neoplasms - diagnosis Lung Neoplasms - drug therapy Lung Neoplasms - epidemiology Lung Neoplasms - pathology Male Medical prognosis Medical sciences Medicine Medicine & Public Health Metastasis Middle Aged Oncology Original Paper Pharmacology. Drug treatments Pneumology Prognosis Retrospective Studies Skin cancer Skin Neoplasms - diagnosis Skin Neoplasms - drug therapy Skin Neoplasms - epidemiology Skin Neoplasms - pathology Skin Neoplasms - secondary Survival Analysis Tumors of the respiratory system and mediastinum Tumors of the skin and soft tissue. Premalignant lesions Young Adult |
| title | Cutaneous metastasis as a initial presentation in advanced non-small cell lung cancer and its poor survival prognosis |
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