Feasibility, Safety, and Therapeutic Efficacy of Human Induced Pluripotent Stem Cell-Derived Cardiomyocyte Sheets in a Porcine Ischemic Cardiomyopathy Model

Human induced pluripotent stem cell-derived cardiomyocytes (hiPS-CMs) are a promising source of cells for regenerating myocardium. However, several issues, especially the large-scale preparation of hiPS-CMs and elimination of undifferentiated iPS cells, must be resolved before hiPS cells can be used...

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Veröffentlicht in:	Circulation (New York, N.Y.) N.Y.), 2012-09, Vol.126 (11), p.S29-S37
Hauptverfasser:	KAWAMURA, Masashi, MIYAGAWA, Shigeru, OKANO, Teruo, SAWA, Yoshiki, MIKI, Kenji, SAITO, Atsuhiro, FUKUSHIMA, Satsuki, HIGUCHI, Takahiro, KAWAMURA, Takuji, KURATANI, Toru, DAIMON, Takashi, SHIMIZU, Tatsuya
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Blood and lymphatic vessels Cardiology. Vascular system Cardiovascular system Cell Culture Techniques - instrumentation Cell Differentiation - drug effects Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous Electrocardiography, Ambulatory Feasibility Studies Female Graft Survival Humans Induced Pluripotent Stem Cells - drug effects Induced Pluripotent Stem Cells - transplantation Medical sciences Myocardial Infarction - diagnostic imaging Myocardial Infarction - pathology Myocardial Infarction - surgery Myocytes, Cardiac - transplantation Pharmacology. Drug treatments Recombinant Fusion Proteins - genetics Recombinant Fusion Proteins - physiology Recovery of Function Retroviridae - genetics Swine Swine, Miniature Temperature Tissue Engineering - methods Transcription Factors - genetics Transcription Factors - physiology Transplantation, Heterologous Ultrasonography Vascular wall Wnt Proteins - pharmacology
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