How useful is preoperative imaging for tumor, node, metastasis (TNM) staging of gastric cancer? A meta-analysis
Background Surgery is the fundamental curative option for gastric cancer patients. Imaging scans are routinely prescribed in an attempt to stage the disease prior to surgery. Consequently, the correlation between radiology exams and pathology is crucial for appropriate treatment planning. Methods Sy...
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| Veröffentlicht in: | Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association 2012-09, Vol.15 (Suppl 1), p.3-18 |
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| container_title | Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association |
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| creator | Seevaratnam, Rajini Cardoso, Roberta Mcgregor, Caitlin Lourenco, Laercio Mahar, Alyson Sutradhar, Rinku Law, Calvin Paszat, Lawrence Coburn, Natalie |
| description | Background
Surgery is the fundamental curative option for gastric cancer patients. Imaging scans are routinely prescribed in an attempt to stage the disease prior to surgery. Consequently, the correlation between radiology exams and pathology is crucial for appropriate treatment planning.
Methods
Systematic searches were conducted using Medline, Embase, and the Cochrane Central Register of Controlled Trials from January 1, 1998 to December 1, 2009. We calculated the accuracy, overstaging rate, understaging rate, Kappa statistic, sensitivity, and specificity for abdominal ultrasound (AUS), computed tomography (CT), magnetic resonance imaging (MRI), and positron emission tomography (PET) with respect to the gold standard (pathology). We also compared the performance of CT by detector number and image type. A meta-analysis was performed.
Results
For pre
-
operative T staging
MRI scans had better performance accuracy than CT and AUS; CT scanners using ≥4 detectors and multi-planar reformatted (MPR) images had higher staging performances than scanners with |
| doi_str_mv | 10.1007/s10120-011-0069-6 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1069206408</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2760099101</sourcerecordid><originalsourceid>FETCH-LOGICAL-c508t-37eb02d3682f66c89894a21898c50c1a576546c19b16c4655e2bee069e3499933</originalsourceid><addsrcrecordid>eNp1kV1LwzAUhoMozq8f4I0EvJlgNadps-ZKhqgT_LiZ1yXLTkdH28ykVfbvPXObiCAEknCe9z2H8zJ2CuIKhBhcBxAQi0gAREIoHakddgCJVJGUIt3dvmMNPXYYwlwISDWofdaLIZODJM0OmBu5T94FLLqKl4EvPLoFetOWH8jL2szKZsYL53nb1c5f8sZN8ZLX2JpAhwT98cvzBafPN-kKPqOKLy23prHob_jwm45MY6olCY7ZXmGqgCeb-4i93d-Nb0fR0-vD4-3wKbKpyNpIDnAi4qlUWVwoZTOd6cTQ1DqjugWTDlSaKAt6AsomKk0xniDSDlAmWmspj1h_7bvw7r3D0OZ1GSxWlWnQdSEHYmOhEpERev4HnbvO07wrSpKXALkyhDVlvQvBY5EvPC3ILwnKV2nk6zRySiNfpZEr0pxtnLtJjdMfxXb9BMRrIFCpmaH_3fo_1y8t-ZKD</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1039330133</pqid></control><display><type>article</type><title>How useful is preoperative imaging for tumor, node, metastasis (TNM) staging of gastric cancer? A meta-analysis</title><source>MEDLINE</source><source>SpringerNature Journals</source><source>EZB-FREE-00999 freely available EZB journals</source><creator>Seevaratnam, Rajini ; Cardoso, Roberta ; Mcgregor, Caitlin ; Lourenco, Laercio ; Mahar, Alyson ; Sutradhar, Rinku ; Law, Calvin ; Paszat, Lawrence ; Coburn, Natalie</creator><creatorcontrib>Seevaratnam, Rajini ; Cardoso, Roberta ; Mcgregor, Caitlin ; Lourenco, Laercio ; Mahar, Alyson ; Sutradhar, Rinku ; Law, Calvin ; Paszat, Lawrence ; Coburn, Natalie</creatorcontrib><description>Background
Surgery is the fundamental curative option for gastric cancer patients. Imaging scans are routinely prescribed in an attempt to stage the disease prior to surgery. Consequently, the correlation between radiology exams and pathology is crucial for appropriate treatment planning.
Methods
Systematic searches were conducted using Medline, Embase, and the Cochrane Central Register of Controlled Trials from January 1, 1998 to December 1, 2009. We calculated the accuracy, overstaging rate, understaging rate, Kappa statistic, sensitivity, and specificity for abdominal ultrasound (AUS), computed tomography (CT), magnetic resonance imaging (MRI), and positron emission tomography (PET) with respect to the gold standard (pathology). We also compared the performance of CT by detector number and image type. A meta-analysis was performed.
Results
For pre
-
operative T staging
MRI scans had better performance accuracy than CT and AUS; CT scanners using ≥4 detectors and multi-planar reformatted (MPR) images had higher staging performances than scanners with <4 detectors and axial images only.
For pre
-
operative N staging
PET had the lowest sensitivity, but the highest specificity among modalities; CT performance did not significantly differ by detector number or addition of MPR images.
For pre
-
operative M staging
performance did not significantly differ by modality, detector number, or MPR images.
Conclusions
The agreement between pre-operative TNM staging by imaging scans and post-operative staging by pathology is not perfect and may affect treatment decisions. Operator dependence and heterogeneity of data may account for the variations in staging performance. Physicians should consider this discrepancy when creating their treatment plans.</description><identifier>ISSN: 1436-3291</identifier><identifier>EISSN: 1436-3305</identifier><identifier>DOI: 10.1007/s10120-011-0069-6</identifier><identifier>PMID: 21837458</identifier><language>eng</language><publisher>Japan: Springer Japan</publisher><subject>Abdominal Surgery ; Cancer Research ; Decision Making ; Diagnostic Imaging - methods ; Gastric cancer ; Gastroenterology ; Humans ; Lymphatic Metastasis ; Medicine ; Medicine & Public Health ; Neoplasm Staging ; Oncology ; Preoperative Care - methods ; Review Article ; Sensitivity and Specificity ; Stomach Neoplasms - diagnosis ; Stomach Neoplasms - pathology ; Stomach Neoplasms - surgery ; Surgical Oncology ; Tomography, X-Ray Computed - methods</subject><ispartof>Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association, 2012-09, Vol.15 (Suppl 1), p.3-18</ispartof><rights>The International Gastric Cancer Association and The Japanese Gastric Cancer Association 2011</rights><rights>The International Gastric Cancer Association and The Japanese Gastric Cancer Association 2012</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c508t-37eb02d3682f66c89894a21898c50c1a576546c19b16c4655e2bee069e3499933</citedby><cites>FETCH-LOGICAL-c508t-37eb02d3682f66c89894a21898c50c1a576546c19b16c4655e2bee069e3499933</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10120-011-0069-6$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10120-011-0069-6$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21837458$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Seevaratnam, Rajini</creatorcontrib><creatorcontrib>Cardoso, Roberta</creatorcontrib><creatorcontrib>Mcgregor, Caitlin</creatorcontrib><creatorcontrib>Lourenco, Laercio</creatorcontrib><creatorcontrib>Mahar, Alyson</creatorcontrib><creatorcontrib>Sutradhar, Rinku</creatorcontrib><creatorcontrib>Law, Calvin</creatorcontrib><creatorcontrib>Paszat, Lawrence</creatorcontrib><creatorcontrib>Coburn, Natalie</creatorcontrib><title>How useful is preoperative imaging for tumor, node, metastasis (TNM) staging of gastric cancer? A meta-analysis</title><title>Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association</title><addtitle>Gastric Cancer</addtitle><addtitle>Gastric Cancer</addtitle><description>Background
Surgery is the fundamental curative option for gastric cancer patients. Imaging scans are routinely prescribed in an attempt to stage the disease prior to surgery. Consequently, the correlation between radiology exams and pathology is crucial for appropriate treatment planning.
Methods
Systematic searches were conducted using Medline, Embase, and the Cochrane Central Register of Controlled Trials from January 1, 1998 to December 1, 2009. We calculated the accuracy, overstaging rate, understaging rate, Kappa statistic, sensitivity, and specificity for abdominal ultrasound (AUS), computed tomography (CT), magnetic resonance imaging (MRI), and positron emission tomography (PET) with respect to the gold standard (pathology). We also compared the performance of CT by detector number and image type. A meta-analysis was performed.
Results
For pre
-
operative T staging
MRI scans had better performance accuracy than CT and AUS; CT scanners using ≥4 detectors and multi-planar reformatted (MPR) images had higher staging performances than scanners with <4 detectors and axial images only.
For pre
-
operative N staging
PET had the lowest sensitivity, but the highest specificity among modalities; CT performance did not significantly differ by detector number or addition of MPR images.
For pre
-
operative M staging
performance did not significantly differ by modality, detector number, or MPR images.
Conclusions
The agreement between pre-operative TNM staging by imaging scans and post-operative staging by pathology is not perfect and may affect treatment decisions. Operator dependence and heterogeneity of data may account for the variations in staging performance. Physicians should consider this discrepancy when creating their treatment plans.</description><subject>Abdominal Surgery</subject><subject>Cancer Research</subject><subject>Decision Making</subject><subject>Diagnostic Imaging - methods</subject><subject>Gastric cancer</subject><subject>Gastroenterology</subject><subject>Humans</subject><subject>Lymphatic Metastasis</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Neoplasm Staging</subject><subject>Oncology</subject><subject>Preoperative Care - methods</subject><subject>Review Article</subject><subject>Sensitivity and Specificity</subject><subject>Stomach Neoplasms - diagnosis</subject><subject>Stomach Neoplasms - pathology</subject><subject>Stomach Neoplasms - surgery</subject><subject>Surgical Oncology</subject><subject>Tomography, X-Ray Computed - methods</subject><issn>1436-3291</issn><issn>1436-3305</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp1kV1LwzAUhoMozq8f4I0EvJlgNadps-ZKhqgT_LiZ1yXLTkdH28ykVfbvPXObiCAEknCe9z2H8zJ2CuIKhBhcBxAQi0gAREIoHakddgCJVJGUIt3dvmMNPXYYwlwISDWofdaLIZODJM0OmBu5T94FLLqKl4EvPLoFetOWH8jL2szKZsYL53nb1c5f8sZN8ZLX2JpAhwT98cvzBafPN-kKPqOKLy23prHob_jwm45MY6olCY7ZXmGqgCeb-4i93d-Nb0fR0-vD4-3wKbKpyNpIDnAi4qlUWVwoZTOd6cTQ1DqjugWTDlSaKAt6AsomKk0xniDSDlAmWmspj1h_7bvw7r3D0OZ1GSxWlWnQdSEHYmOhEpERev4HnbvO07wrSpKXALkyhDVlvQvBY5EvPC3ILwnKV2nk6zRySiNfpZEr0pxtnLtJjdMfxXb9BMRrIFCpmaH_3fo_1y8t-ZKD</recordid><startdate>20120901</startdate><enddate>20120901</enddate><creator>Seevaratnam, Rajini</creator><creator>Cardoso, Roberta</creator><creator>Mcgregor, Caitlin</creator><creator>Lourenco, Laercio</creator><creator>Mahar, Alyson</creator><creator>Sutradhar, Rinku</creator><creator>Law, Calvin</creator><creator>Paszat, Lawrence</creator><creator>Coburn, Natalie</creator><general>Springer Japan</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T5</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20120901</creationdate><title>How useful is preoperative imaging for tumor, node, metastasis (TNM) staging of gastric cancer? A meta-analysis</title><author>Seevaratnam, Rajini ; Cardoso, Roberta ; Mcgregor, Caitlin ; Lourenco, Laercio ; Mahar, Alyson ; Sutradhar, Rinku ; Law, Calvin ; Paszat, Lawrence ; Coburn, Natalie</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c508t-37eb02d3682f66c89894a21898c50c1a576546c19b16c4655e2bee069e3499933</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Abdominal Surgery</topic><topic>Cancer Research</topic><topic>Decision Making</topic><topic>Diagnostic Imaging - methods</topic><topic>Gastric cancer</topic><topic>Gastroenterology</topic><topic>Humans</topic><topic>Lymphatic Metastasis</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Neoplasm Staging</topic><topic>Oncology</topic><topic>Preoperative Care - methods</topic><topic>Review Article</topic><topic>Sensitivity and Specificity</topic><topic>Stomach Neoplasms - diagnosis</topic><topic>Stomach Neoplasms - pathology</topic><topic>Stomach Neoplasms - surgery</topic><topic>Surgical Oncology</topic><topic>Tomography, X-Ray Computed - methods</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Seevaratnam, Rajini</creatorcontrib><creatorcontrib>Cardoso, Roberta</creatorcontrib><creatorcontrib>Mcgregor, Caitlin</creatorcontrib><creatorcontrib>Lourenco, Laercio</creatorcontrib><creatorcontrib>Mahar, Alyson</creatorcontrib><creatorcontrib>Sutradhar, Rinku</creatorcontrib><creatorcontrib>Law, Calvin</creatorcontrib><creatorcontrib>Paszat, Lawrence</creatorcontrib><creatorcontrib>Coburn, Natalie</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Immunology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Seevaratnam, Rajini</au><au>Cardoso, Roberta</au><au>Mcgregor, Caitlin</au><au>Lourenco, Laercio</au><au>Mahar, Alyson</au><au>Sutradhar, Rinku</au><au>Law, Calvin</au><au>Paszat, Lawrence</au><au>Coburn, Natalie</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>How useful is preoperative imaging for tumor, node, metastasis (TNM) staging of gastric cancer? A meta-analysis</atitle><jtitle>Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association</jtitle><stitle>Gastric Cancer</stitle><addtitle>Gastric Cancer</addtitle><date>2012-09-01</date><risdate>2012</risdate><volume>15</volume><issue>Suppl 1</issue><spage>3</spage><epage>18</epage><pages>3-18</pages><issn>1436-3291</issn><eissn>1436-3305</eissn><abstract>Background
Surgery is the fundamental curative option for gastric cancer patients. Imaging scans are routinely prescribed in an attempt to stage the disease prior to surgery. Consequently, the correlation between radiology exams and pathology is crucial for appropriate treatment planning.
Methods
Systematic searches were conducted using Medline, Embase, and the Cochrane Central Register of Controlled Trials from January 1, 1998 to December 1, 2009. We calculated the accuracy, overstaging rate, understaging rate, Kappa statistic, sensitivity, and specificity for abdominal ultrasound (AUS), computed tomography (CT), magnetic resonance imaging (MRI), and positron emission tomography (PET) with respect to the gold standard (pathology). We also compared the performance of CT by detector number and image type. A meta-analysis was performed.
Results
For pre
-
operative T staging
MRI scans had better performance accuracy than CT and AUS; CT scanners using ≥4 detectors and multi-planar reformatted (MPR) images had higher staging performances than scanners with <4 detectors and axial images only.
For pre
-
operative N staging
PET had the lowest sensitivity, but the highest specificity among modalities; CT performance did not significantly differ by detector number or addition of MPR images.
For pre
-
operative M staging
performance did not significantly differ by modality, detector number, or MPR images.
Conclusions
The agreement between pre-operative TNM staging by imaging scans and post-operative staging by pathology is not perfect and may affect treatment decisions. Operator dependence and heterogeneity of data may account for the variations in staging performance. Physicians should consider this discrepancy when creating their treatment plans.</abstract><cop>Japan</cop><pub>Springer Japan</pub><pmid>21837458</pmid><doi>10.1007/s10120-011-0069-6</doi><tpages>16</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 1436-3291 |
| ispartof | Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association, 2012-09, Vol.15 (Suppl 1), p.3-18 |
| issn | 1436-3291 1436-3305 |
| language | eng |
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| source | MEDLINE; SpringerNature Journals; EZB-FREE-00999 freely available EZB journals |
| subjects | Abdominal Surgery Cancer Research Decision Making Diagnostic Imaging - methods Gastric cancer Gastroenterology Humans Lymphatic Metastasis Medicine Medicine & Public Health Neoplasm Staging Oncology Preoperative Care - methods Review Article Sensitivity and Specificity Stomach Neoplasms - diagnosis Stomach Neoplasms - pathology Stomach Neoplasms - surgery Surgical Oncology Tomography, X-Ray Computed - methods |
| title | How useful is preoperative imaging for tumor, node, metastasis (TNM) staging of gastric cancer? A meta-analysis |
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