Influence of Environmental and Genetic Factors on CYP1A2 Activity in Individuals of South Asian and European Ancestry
The drug‐metabolizing enzyme CYP1A2 contributes to the metabolism of a number of commonly used medicines and displays wide interindividual variability. The aim of this study was to investigate CYP1A2 activity in a population of South Asian ancestry and compare it with a population of European ancest...
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| Veröffentlicht in: | Clinical pharmacology and therapeutics 2012-10, Vol.92 (4), p.511-519 |
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| creator | Perera, V Gross, A S McLachlan, A J |
| description | The drug‐metabolizing enzyme CYP1A2 contributes to the metabolism of a number of commonly used medicines and displays wide interindividual variability. The aim of this study was to investigate CYP1A2 activity in a population of South Asian ancestry and compare it with a population of European ancestry. CYP1A2 activity was determined using the 4 h paraxanthine/caffeine saliva concentration ratio following a 100‐mg oral dose of caffeine in healthy individuals of South Asian (n = 166) and European (n = 166) ancestry. Participants were surveyed for extrinsic ethnic factors and genotyped for polymorphisms in CYP1A2 and related genes. Significantly lower CYP1A2 activity was observed in South Asian participants (median: 0.42; range: 0.10–1.06) as compared with European participants (0.54; 0.12–1.64) (P < 0.01). Multiple linear regression indicated that 41% of the variability in CYP1A2 activity could be explained by the diet, lifestyle, and genetic factors studied.
Clinical Pharmacology & Therapeutics (2012); 92 4, 511–519. doi:10.1038/clpt.2012.139 |
| doi_str_mv | 10.1038/clpt.2012.139 |
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Clinical Pharmacology & Therapeutics (2012); 92 4, 511–519. doi:10.1038/clpt.2012.139</description><subject>Adolescent</subject><subject>Adult</subject><subject>Asia, Western - ethnology</subject><subject>Asian Continental Ancestry Group - ethnology</subject><subject>Asian Continental Ancestry Group - genetics</subject><subject>Australia - ethnology</subject><subject>Cross-Sectional Studies</subject><subject>Cytochrome P-450 CYP1A2 - genetics</subject><subject>Cytochrome P-450 CYP1A2 - metabolism</subject><subject>Environment</subject><subject>Enzyme Activation - physiology</subject><subject>European Continental Ancestry Group - ethnology</subject><subject>European Continental Ancestry Group - genetics</subject><subject>Female</subject><subject>Humans</subject><subject>India - ethnology</subject><subject>Life Style - ethnology</subject><subject>Male</subject><subject>Prospective Studies</subject><subject>Sri Lanka - ethnology</subject><subject>Young Adult</subject><issn>0009-9236</issn><issn>1532-6535</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kM9v0zAYhi3ExLrBkSvykUuKfySOfYyirquoWBFFwMlyHFcYUruznW3973Fo2ZGT_UqP3-_zA8BbjOYYUf5BD4c0JwiTOabiBZjhipKCVbR6CWYIIVEIQtkluIrxV46l4PwVuCRElJwLMgPjyu2G0ThtoN_BhXuwwbu9cUkNULkeLo0zyWp4o3TyIULvYPtjgxsCG53sg01HaB1cuT7f-1ENcar54sf0EzbRKve3ZDEGfzA5NHlOTOH4GlzsMmvenM9r8PVmsW1vi_XdctU260KXZS0KLjhmNWWKVlgZYRCtGdWYm05wRTirREmw4bTvqir_EnPdlR0rSZ1hxruSXoP3p95D8PdjHi33NmozDMoZP0aJERMEZRU8o8UJ1cHHGMxOHoLdq3DMkJxMy8m0nEzLbDrz787VY7c3_TP9T20GxAl4tIM5_r9Ntpttu95sp3wqPy9jYzJPz29V-C2zj7qS3z4tJaWMfMYfkfxO_wBkIpkZ</recordid><startdate>201210</startdate><enddate>201210</enddate><creator>Perera, V</creator><creator>Gross, A S</creator><creator>McLachlan, A J</creator><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201210</creationdate><title>Influence of Environmental and Genetic Factors on CYP1A2 Activity in Individuals of South Asian and European Ancestry</title><author>Perera, V ; Gross, A S ; McLachlan, A J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4479-89816736a351ae9e03763c18eb98a28659421e83db5523618cb4b6427ae968b43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Asia, Western - ethnology</topic><topic>Asian Continental Ancestry Group - ethnology</topic><topic>Asian Continental Ancestry Group - genetics</topic><topic>Australia - ethnology</topic><topic>Cross-Sectional Studies</topic><topic>Cytochrome P-450 CYP1A2 - genetics</topic><topic>Cytochrome P-450 CYP1A2 - metabolism</topic><topic>Environment</topic><topic>Enzyme Activation - physiology</topic><topic>European Continental Ancestry Group - ethnology</topic><topic>European Continental Ancestry Group - genetics</topic><topic>Female</topic><topic>Humans</topic><topic>India - ethnology</topic><topic>Life Style - ethnology</topic><topic>Male</topic><topic>Prospective Studies</topic><topic>Sri Lanka - ethnology</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Perera, V</creatorcontrib><creatorcontrib>Gross, A S</creatorcontrib><creatorcontrib>McLachlan, A J</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical pharmacology and therapeutics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Perera, V</au><au>Gross, A S</au><au>McLachlan, A J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Influence of Environmental and Genetic Factors on CYP1A2 Activity in Individuals of South Asian and European Ancestry</atitle><jtitle>Clinical pharmacology and therapeutics</jtitle><addtitle>Clinical Pharmacology & Therapeutics</addtitle><date>2012-10</date><risdate>2012</risdate><volume>92</volume><issue>4</issue><spage>511</spage><epage>519</epage><pages>511-519</pages><issn>0009-9236</issn><eissn>1532-6535</eissn><abstract>The drug‐metabolizing enzyme CYP1A2 contributes to the metabolism of a number of commonly used medicines and displays wide interindividual variability. 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| subjects | Adolescent Adult Asia, Western - ethnology Asian Continental Ancestry Group - ethnology Asian Continental Ancestry Group - genetics Australia - ethnology Cross-Sectional Studies Cytochrome P-450 CYP1A2 - genetics Cytochrome P-450 CYP1A2 - metabolism Environment Enzyme Activation - physiology European Continental Ancestry Group - ethnology European Continental Ancestry Group - genetics Female Humans India - ethnology Life Style - ethnology Male Prospective Studies Sri Lanka - ethnology Young Adult |
| title | Influence of Environmental and Genetic Factors on CYP1A2 Activity in Individuals of South Asian and European Ancestry |
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