The Effects of N-acetylcysteine on Ifosfamide Efficacy in a Mouse Xenograft Model

Nephrotoxicity is observed in 30% of children treated with ifosfamide. We have shown that n-acetylcysteine (NAC) successfully mitigates nephrotoxicity of ifosfamide in cell and rodent models. However, before this treatment is evaluated clinically, it must be established that NAC does not interfere w...

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Veröffentlicht in:	Anticancer research 2012-09, Vol.32 (9), p.3791-3798
Hauptverfasser:	HANLY, L, FIGUEREDO, R, RIEDER, M. J, KOROPATNICK, J, KOREN, G
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcysteine - pharmacology Animals Antineoplastic Agents, Alkylating - pharmacology Biological and medical sciences Bone Neoplasms - drug therapy Bone Neoplasms - pathology Cell Growth Processes - drug effects Cell Line, Tumor Diseases of the osteoarticular system Drug Interactions Female Humans Ifosfamide - pharmacology Medical sciences Mice Sarcoma, Ewing - drug therapy Sarcoma, Ewing - pathology Treatment Outcome Tumors Tumors of striated muscle and skeleton Xenograft Model Antitumor Assays
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