Smad7 siRNA inhibit expression of extracellular matrix in trabecular meshwork cells treated with TGF- beta 2

Purpose: Extracellular matrix (ECM) deposits lead to elevated resistance of aqueous humor outflow which play an important role in the development of primary open angle glaucoma (POAG). The TGF- beta 2 (transforming growth factor beta )/Smad (signaling mathers against decapentaplegic) pathway is know...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Molecular vision 2012-07, Vol.18, p.1881-1884
Hauptverfasser:	Su, Y, Yang, C-YC, Li, Z, Xu, F, Zhang, L, Wang, F, Zhao, S
Format:	Artikel
Sprache:	eng
Schlagworte:	Deposits Extracellular matrix Fibronectin Glaucoma Laminin Plasmids Signal transduction siRNA Smad protein Smad7 protein Transfection Transforming growth factor- beta Vision Western blotting
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!