The new iminothiadiazole derivative VP1.14 ameliorates hippocampal damage after an excitotoxic injury

J. Neurochem. (2012) 122, 1193–1202. Increased levels of glutamate causing excitotoxic damage accompany many neurological disorders. A well‐characterized model of excitotoxic damage involves administration of kainic acid (KA), which causes limbic seizure activity and subsequent neuronal death, parti...

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Veröffentlicht in:	Journal of neurochemistry 2012-09, Vol.122 (6), p.1193-1202
Hauptverfasser:	Susín, Cristina, Morales-Garcia, Jose A., Aguilar-Morante, Diana, Palomo, Valle, Sanz-Sancristobal, Marina, Alonso-Gil, Sandra, Gil, Carmen, Santos, Angel, Martinez, Ana, Perez-Castillo, Ana
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Factors Animals Animals, Newborn Astrocytes Biological and medical sciences Brain damage Brain injury Cell culture Cell Line Cyclic AMP Cytokines Dopamine Enzymes Excitatory Amino Acid Agonists - toxicity Excitotoxicity GSK-3 Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy Hippocampus Hippocampus - drug effects Hippocampus - metabolism Hippocampus - pathology Inflammation Inhibitor drugs Injections, Intralesional Injuries Injuries of the nervous system and the skull. Diseases due to physical agents Kainic acid Kinases Male Medical sciences Mice Nervous system (semeiology, syndromes) Neurochemistry Neurodegenerative diseases neuroinflammation Neurological diseases Neurology Neuronal-glial interactions Neurons Neuroprotection Neuroprotective Agents - pharmacology PDE7 phosphodiesterase Phosphorylation - drug effects Primary Cell Culture Pyramidal cells Rats Rats, Wistar Seizures Thiadiazoles - pharmacology Traumas. Diseases due to physical agents
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