Risk stratification and prognostic assessment by myocardial perfusion-gated SPECT in patients with left bundle-branch block and low-intermediate cardiac risk
Objective In high-risk patients with left bundle-branch block (LBBB), functional but not perfusion parameters yield incremental prognostic information. The aim of our study was to evaluate the prognostic value of gated single photon emission computed tomography (SPECT) in low-intermediate risk LBBB...
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| Veröffentlicht in: | Annals of nuclear medicine 2012-08, Vol.26 (7), p.559-570 |
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| creator | Fovino, Luca Nai Saladini, Giorgio Mormino, Gino Paolo Saladini, Francesca Razzolini, Renato Evangelista, Laura |
| description | Objective
In high-risk patients with left bundle-branch block (LBBB), functional but not perfusion parameters yield incremental prognostic information. The aim of our study was to evaluate the prognostic value of gated single photon emission computed tomography (SPECT) in low-intermediate risk LBBB patients.
Methods
One hundred seventy-six subjects underwent stress-rest dual-day protocol 99mTc sestamibi-gated SPECT and were dichotomized in two groups: without LBBB (Group 1,
n
= 86) and with LBBB (Group 2,
n
= 90). Patients were followed for 32 ± 18 months. Cox regression multivariate analysis was used to determine which variable was the best predictor of cardiac event. Event-free survival curves were computed by Kaplan–Meier method.
Results
Myocardial perfusion scintigraphy was abnormal in 32 and 60 patients for Groups 1 and 2, respectively (37 vs. 67 %,
p
|
| doi_str_mv | 10.1007/s12149-012-0613-4 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1069201578</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2748892371</sourcerecordid><originalsourceid>FETCH-LOGICAL-c458t-d5b088e631876a590db52d1230ad9c4e279c86624693c62cb69bf6e8d55b35f53</originalsourceid><addsrcrecordid>eNqNkU9rFTEUxYMo9rX6AdxIwI2baJLJv1nKo7VCQdG6HjJJ5jXtTOaZm6G8D-N3Nc-pIoLgJlnkd869JwehF4y-YZTqt8A4Ey2hjBOqWEPEI7RhRgmiRNM8RhvaMkE0M_oEnQLcUsqNNPwpOuFcKdpqukHfP0e4w1CyLXGIrp5zwjZ5vM_zLs1QosMWIABMIRXcH_B0mJ3NPtoR70MeFqgKsrMlePzl0_n2GseE99Wn4oDvY7nBYxiqckl-DKTPNrkb3I-zu_s5Z5zvSUwl5ClUzxLwau5wros9Q08GO0J4_nCfoa8X59fbS3L18f2H7bsr4oQ0hXjZU2OCampUZWVLfS-5Z7yh1rdOBK5bZ5TiQrWNU9z1qu0HFYyXsm_kIJsz9Hr1ram_LQFKN0VwYRxtCvMCHaOq5ZRJbf4DbYSSWjNW0Vd_obfzklMNcqQ0N1zJI8VWyuUZIIeh2-c42XyoUHesuVtr7mrN3bHmTlTNywfnpa__9lvxq9cK8BWA-pR2If85-l-uPwDLibQI</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1037282651</pqid></control><display><type>article</type><title>Risk stratification and prognostic assessment by myocardial perfusion-gated SPECT in patients with left bundle-branch block and low-intermediate cardiac risk</title><source>MEDLINE</source><source>Springer Nature - Complete Springer Journals</source><creator>Fovino, Luca Nai ; Saladini, Giorgio ; Mormino, Gino Paolo ; Saladini, Francesca ; Razzolini, Renato ; Evangelista, Laura</creator><creatorcontrib>Fovino, Luca Nai ; Saladini, Giorgio ; Mormino, Gino Paolo ; Saladini, Francesca ; Razzolini, Renato ; Evangelista, Laura</creatorcontrib><description>Objective
In high-risk patients with left bundle-branch block (LBBB), functional but not perfusion parameters yield incremental prognostic information. The aim of our study was to evaluate the prognostic value of gated single photon emission computed tomography (SPECT) in low-intermediate risk LBBB patients.
Methods
One hundred seventy-six subjects underwent stress-rest dual-day protocol 99mTc sestamibi-gated SPECT and were dichotomized in two groups: without LBBB (Group 1,
n
= 86) and with LBBB (Group 2,
n
= 90). Patients were followed for 32 ± 18 months. Cox regression multivariate analysis was used to determine which variable was the best predictor of cardiac event. Event-free survival curves were computed by Kaplan–Meier method.
Results
Myocardial perfusion scintigraphy was abnormal in 32 and 60 patients for Groups 1 and 2, respectively (37 vs. 67 %,
p
< 0.001). In Groups 1 and 2, the mean summed stress score (SSS) was 3.7 ± 5.6 versus 6.7 ± 6.4, while the mean summed difference score (SDS) was 1.6 ± 2.5 versus 2.7 ± 3.3 (both
p
< 0.005); therefore 34 % of patients in Group 1 and 53 % of those in Group 2 presented myocardial ischemia. All functional parameters were significantly different between the two subsets (all
p
< 0.005). Follow-up was completed in 161 patients (92 %); 10 events occurred in Group 1 and 20 in Group 2 (14 vs. 25 %). The event-free survival was significantly higher in patients with normal than in those with abnormal scan (85 vs. 63 %,
p
< 0.005); moreover, the prognosis of patients with LBBB was significantly worse. At multivariate analysis, SDS was found to be the only independent predictor of cardiac events both in all patients and in LBBB population (HR 3.08, and HR 4.99,
p
< 0.05).
Conclusions
This is the first study to assess the prognostic value of gated SPECT in patients with LBBB and low-intermediate cardiac risk. Both perfusion and functional data obtained by gated SPECT are different between patients with and without LBBB. However, SDS is the only predictor of events. Thus, the amount of reversible ischemia at gated SPECT has a discriminative power in stratifying the cardiac risk of LBBB population.</description><identifier>ISSN: 0914-7187</identifier><identifier>EISSN: 1864-6433</identifier><identifier>DOI: 10.1007/s12149-012-0613-4</identifier><identifier>PMID: 22660970</identifier><language>eng</language><publisher>Japan: Springer Japan</publisher><subject>Aged ; Bundle-Branch Block - diagnostic imaging ; Bundle-Branch Block - physiopathology ; Cardiac-Gated Single-Photon Emission Computer-Assisted Tomography ; Computed tomography ; Data processing ; Emissions ; Female ; Heart ; Humans ; Imaging ; Ischemia ; Male ; Medicine ; Medicine & Public Health ; Middle Aged ; Multivariate analysis ; Myocardial ischemia ; Myocardial Perfusion Imaging ; Nuclear Medicine ; Original Article ; Perfusion ; Prognosis ; Radiology ; Regional Blood Flow ; Retrospective Studies ; Risk Assessment ; Risk factors ; Risk groups ; Scintigraphy ; Single photon emission computed tomography ; Sodium lauryl sulfate ; Stratification ; Stress ; Survival</subject><ispartof>Annals of nuclear medicine, 2012-08, Vol.26 (7), p.559-570</ispartof><rights>The Japanese Society of Nuclear Medicine 2012</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c458t-d5b088e631876a590db52d1230ad9c4e279c86624693c62cb69bf6e8d55b35f53</citedby><cites>FETCH-LOGICAL-c458t-d5b088e631876a590db52d1230ad9c4e279c86624693c62cb69bf6e8d55b35f53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s12149-012-0613-4$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s12149-012-0613-4$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22660970$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fovino, Luca Nai</creatorcontrib><creatorcontrib>Saladini, Giorgio</creatorcontrib><creatorcontrib>Mormino, Gino Paolo</creatorcontrib><creatorcontrib>Saladini, Francesca</creatorcontrib><creatorcontrib>Razzolini, Renato</creatorcontrib><creatorcontrib>Evangelista, Laura</creatorcontrib><title>Risk stratification and prognostic assessment by myocardial perfusion-gated SPECT in patients with left bundle-branch block and low-intermediate cardiac risk</title><title>Annals of nuclear medicine</title><addtitle>Ann Nucl Med</addtitle><addtitle>Ann Nucl Med</addtitle><description>Objective
In high-risk patients with left bundle-branch block (LBBB), functional but not perfusion parameters yield incremental prognostic information. The aim of our study was to evaluate the prognostic value of gated single photon emission computed tomography (SPECT) in low-intermediate risk LBBB patients.
Methods
One hundred seventy-six subjects underwent stress-rest dual-day protocol 99mTc sestamibi-gated SPECT and were dichotomized in two groups: without LBBB (Group 1,
n
= 86) and with LBBB (Group 2,
n
= 90). Patients were followed for 32 ± 18 months. Cox regression multivariate analysis was used to determine which variable was the best predictor of cardiac event. Event-free survival curves were computed by Kaplan–Meier method.
Results
Myocardial perfusion scintigraphy was abnormal in 32 and 60 patients for Groups 1 and 2, respectively (37 vs. 67 %,
p
< 0.001). In Groups 1 and 2, the mean summed stress score (SSS) was 3.7 ± 5.6 versus 6.7 ± 6.4, while the mean summed difference score (SDS) was 1.6 ± 2.5 versus 2.7 ± 3.3 (both
p
< 0.005); therefore 34 % of patients in Group 1 and 53 % of those in Group 2 presented myocardial ischemia. All functional parameters were significantly different between the two subsets (all
p
< 0.005). Follow-up was completed in 161 patients (92 %); 10 events occurred in Group 1 and 20 in Group 2 (14 vs. 25 %). The event-free survival was significantly higher in patients with normal than in those with abnormal scan (85 vs. 63 %,
p
< 0.005); moreover, the prognosis of patients with LBBB was significantly worse. At multivariate analysis, SDS was found to be the only independent predictor of cardiac events both in all patients and in LBBB population (HR 3.08, and HR 4.99,
p
< 0.05).
Conclusions
This is the first study to assess the prognostic value of gated SPECT in patients with LBBB and low-intermediate cardiac risk. Both perfusion and functional data obtained by gated SPECT are different between patients with and without LBBB. However, SDS is the only predictor of events. Thus, the amount of reversible ischemia at gated SPECT has a discriminative power in stratifying the cardiac risk of LBBB population.</description><subject>Aged</subject><subject>Bundle-Branch Block - diagnostic imaging</subject><subject>Bundle-Branch Block - physiopathology</subject><subject>Cardiac-Gated Single-Photon Emission Computer-Assisted Tomography</subject><subject>Computed tomography</subject><subject>Data processing</subject><subject>Emissions</subject><subject>Female</subject><subject>Heart</subject><subject>Humans</subject><subject>Imaging</subject><subject>Ischemia</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Multivariate analysis</subject><subject>Myocardial ischemia</subject><subject>Myocardial Perfusion Imaging</subject><subject>Nuclear Medicine</subject><subject>Original Article</subject><subject>Perfusion</subject><subject>Prognosis</subject><subject>Radiology</subject><subject>Regional Blood Flow</subject><subject>Retrospective Studies</subject><subject>Risk Assessment</subject><subject>Risk factors</subject><subject>Risk groups</subject><subject>Scintigraphy</subject><subject>Single photon emission computed tomography</subject><subject>Sodium lauryl sulfate</subject><subject>Stratification</subject><subject>Stress</subject><subject>Survival</subject><issn>0914-7187</issn><issn>1864-6433</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqNkU9rFTEUxYMo9rX6AdxIwI2baJLJv1nKo7VCQdG6HjJJ5jXtTOaZm6G8D-N3Nc-pIoLgJlnkd869JwehF4y-YZTqt8A4Ey2hjBOqWEPEI7RhRgmiRNM8RhvaMkE0M_oEnQLcUsqNNPwpOuFcKdpqukHfP0e4w1CyLXGIrp5zwjZ5vM_zLs1QosMWIABMIRXcH_B0mJ3NPtoR70MeFqgKsrMlePzl0_n2GseE99Wn4oDvY7nBYxiqckl-DKTPNrkb3I-zu_s5Z5zvSUwl5ClUzxLwau5wros9Q08GO0J4_nCfoa8X59fbS3L18f2H7bsr4oQ0hXjZU2OCampUZWVLfS-5Z7yh1rdOBK5bZ5TiQrWNU9z1qu0HFYyXsm_kIJsz9Hr1ram_LQFKN0VwYRxtCvMCHaOq5ZRJbf4DbYSSWjNW0Vd_obfzklMNcqQ0N1zJI8VWyuUZIIeh2-c42XyoUHesuVtr7mrN3bHmTlTNywfnpa__9lvxq9cK8BWA-pR2If85-l-uPwDLibQI</recordid><startdate>20120801</startdate><enddate>20120801</enddate><creator>Fovino, Luca Nai</creator><creator>Saladini, Giorgio</creator><creator>Mormino, Gino Paolo</creator><creator>Saladini, Francesca</creator><creator>Razzolini, Renato</creator><creator>Evangelista, Laura</creator><general>Springer Japan</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7RV</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>M7P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>PHGZM</scope><scope>PHGZT</scope><scope>PJZUB</scope><scope>PKEHL</scope><scope>PPXIY</scope><scope>PQEST</scope><scope>PQGLB</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>7QO</scope><scope>7U1</scope><scope>7U2</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope></search><sort><creationdate>20120801</creationdate><title>Risk stratification and prognostic assessment by myocardial perfusion-gated SPECT in patients with left bundle-branch block and low-intermediate cardiac risk</title><author>Fovino, Luca Nai ; Saladini, Giorgio ; Mormino, Gino Paolo ; Saladini, Francesca ; Razzolini, Renato ; Evangelista, Laura</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c458t-d5b088e631876a590db52d1230ad9c4e279c86624693c62cb69bf6e8d55b35f53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Aged</topic><topic>Bundle-Branch Block - diagnostic imaging</topic><topic>Bundle-Branch Block - physiopathology</topic><topic>Cardiac-Gated Single-Photon Emission Computer-Assisted Tomography</topic><topic>Computed tomography</topic><topic>Data processing</topic><topic>Emissions</topic><topic>Female</topic><topic>Heart</topic><topic>Humans</topic><topic>Imaging</topic><topic>Ischemia</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Multivariate analysis</topic><topic>Myocardial ischemia</topic><topic>Myocardial Perfusion Imaging</topic><topic>Nuclear Medicine</topic><topic>Original Article</topic><topic>Perfusion</topic><topic>Prognosis</topic><topic>Radiology</topic><topic>Regional Blood Flow</topic><topic>Retrospective Studies</topic><topic>Risk Assessment</topic><topic>Risk factors</topic><topic>Risk groups</topic><topic>Scintigraphy</topic><topic>Single photon emission computed tomography</topic><topic>Sodium lauryl sulfate</topic><topic>Stratification</topic><topic>Stress</topic><topic>Survival</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fovino, Luca Nai</creatorcontrib><creatorcontrib>Saladini, Giorgio</creatorcontrib><creatorcontrib>Mormino, Gino Paolo</creatorcontrib><creatorcontrib>Saladini, Francesca</creatorcontrib><creatorcontrib>Razzolini, Renato</creatorcontrib><creatorcontrib>Evangelista, Laura</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>ProQuest Central (New)</collection><collection>ProQuest One Academic (New)</collection><collection>ProQuest Health & Medical Research Collection</collection><collection>ProQuest One Academic Middle East (New)</collection><collection>ProQuest One Health & Nursing</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Applied & Life Sciences</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>Biotechnology Research Abstracts</collection><collection>Risk Abstracts</collection><collection>Safety Science and Risk</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Annals of nuclear medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fovino, Luca Nai</au><au>Saladini, Giorgio</au><au>Mormino, Gino Paolo</au><au>Saladini, Francesca</au><au>Razzolini, Renato</au><au>Evangelista, Laura</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Risk stratification and prognostic assessment by myocardial perfusion-gated SPECT in patients with left bundle-branch block and low-intermediate cardiac risk</atitle><jtitle>Annals of nuclear medicine</jtitle><stitle>Ann Nucl Med</stitle><addtitle>Ann Nucl Med</addtitle><date>2012-08-01</date><risdate>2012</risdate><volume>26</volume><issue>7</issue><spage>559</spage><epage>570</epage><pages>559-570</pages><issn>0914-7187</issn><eissn>1864-6433</eissn><abstract>Objective
In high-risk patients with left bundle-branch block (LBBB), functional but not perfusion parameters yield incremental prognostic information. The aim of our study was to evaluate the prognostic value of gated single photon emission computed tomography (SPECT) in low-intermediate risk LBBB patients.
Methods
One hundred seventy-six subjects underwent stress-rest dual-day protocol 99mTc sestamibi-gated SPECT and were dichotomized in two groups: without LBBB (Group 1,
n
= 86) and with LBBB (Group 2,
n
= 90). Patients were followed for 32 ± 18 months. Cox regression multivariate analysis was used to determine which variable was the best predictor of cardiac event. Event-free survival curves were computed by Kaplan–Meier method.
Results
Myocardial perfusion scintigraphy was abnormal in 32 and 60 patients for Groups 1 and 2, respectively (37 vs. 67 %,
p
< 0.001). In Groups 1 and 2, the mean summed stress score (SSS) was 3.7 ± 5.6 versus 6.7 ± 6.4, while the mean summed difference score (SDS) was 1.6 ± 2.5 versus 2.7 ± 3.3 (both
p
< 0.005); therefore 34 % of patients in Group 1 and 53 % of those in Group 2 presented myocardial ischemia. All functional parameters were significantly different between the two subsets (all
p
< 0.005). Follow-up was completed in 161 patients (92 %); 10 events occurred in Group 1 and 20 in Group 2 (14 vs. 25 %). The event-free survival was significantly higher in patients with normal than in those with abnormal scan (85 vs. 63 %,
p
< 0.005); moreover, the prognosis of patients with LBBB was significantly worse. At multivariate analysis, SDS was found to be the only independent predictor of cardiac events both in all patients and in LBBB population (HR 3.08, and HR 4.99,
p
< 0.05).
Conclusions
This is the first study to assess the prognostic value of gated SPECT in patients with LBBB and low-intermediate cardiac risk. Both perfusion and functional data obtained by gated SPECT are different between patients with and without LBBB. However, SDS is the only predictor of events. Thus, the amount of reversible ischemia at gated SPECT has a discriminative power in stratifying the cardiac risk of LBBB population.</abstract><cop>Japan</cop><pub>Springer Japan</pub><pmid>22660970</pmid><doi>10.1007/s12149-012-0613-4</doi><tpages>12</tpages></addata></record> |
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| ispartof | Annals of nuclear medicine, 2012-08, Vol.26 (7), p.559-570 |
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| language | eng |
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| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Aged Bundle-Branch Block - diagnostic imaging Bundle-Branch Block - physiopathology Cardiac-Gated Single-Photon Emission Computer-Assisted Tomography Computed tomography Data processing Emissions Female Heart Humans Imaging Ischemia Male Medicine Medicine & Public Health Middle Aged Multivariate analysis Myocardial ischemia Myocardial Perfusion Imaging Nuclear Medicine Original Article Perfusion Prognosis Radiology Regional Blood Flow Retrospective Studies Risk Assessment Risk factors Risk groups Scintigraphy Single photon emission computed tomography Sodium lauryl sulfate Stratification Stress Survival |
| title | Risk stratification and prognostic assessment by myocardial perfusion-gated SPECT in patients with left bundle-branch block and low-intermediate cardiac risk |
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