Perampanel Study 207: long-term open-label evaluation in patients with epilepsy

Objectives Evaluate interim long‐term tolerability, safety and efficacy of adjunctive perampanel, a novel α‐amino‐3‐hydroxy‐5‐methyl‐5‐isoxazolepropionic acid (AMPA)‐receptor antagonist, in patients with refractory partial‐onset seizures. Materials and methods Study 207, an open‐label extension (OLE...

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Veröffentlicht in:	Acta neurologica Scandinavica 2012-10, Vol.126 (4), p.263-269
Hauptverfasser:	Rektor, I., Krauss, G. L., Bar, M., Biton, V., Klapper, J. A., Vaiciene-Magistris, N., Kuba, R., Squillacote, D., Gee, M., Kumar, D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aged Anticonvulsants - therapeutic use antiepileptic drugs Biological and medical sciences Data processing Dose-Response Relationship, Drug Double-Blind Method Drug Administration Schedule Drug Therapy, Combination Epilepsy Epilepsy - drug therapy Female glutamate Headache Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy Humans long-term safety Longitudinal Studies Male Medical sciences Middle Aged Nervous system (semeiology, syndromes) Neurology open-label extension perampanel post-synaptic Pyridones - therapeutic use Seizures Standard deviation Titration Treatment Outcome Young Adult α-amino-3-hydroxy-5-methyl-5-isoxazolepropionic acid
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