The role of eis mutations in the development of kanamycin resistance in Mycobacterium tuberculosis isolates from the Moscow region

Kanamycin is an important second-line drug used to treat multidrug-resistant (MDR) tuberculosis (TB). Molecular analysis of the rrs gene seems to be not enough to identify every case of kanamycin resistance. In the present study we evaluated the incidence of eis mutations in kanamycin-resistant Myco...

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Veröffentlicht in:	Journal of antimicrobial chemotherapy 2012-09, Vol.67 (9), p.2107-2109
Hauptverfasser:	Gikalo, Marina B, Nosova, Elena Y, Krylova, Ludmila Y, Moroz, Arkadyi M
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetyltransferases Antigens, Bacterial - genetics Antigens, Bacterial - metabolism Bacterial Proteins - genetics Bacterial Proteins - metabolism Clinical isolates Drug resistance Genetics Genotype & phenotype Gram-positive bacteria Humans Kanamycin Kanamycin Resistance Microbial Sensitivity Tests Moscow Mutant Proteins - genetics Mutant Proteins - metabolism Mutation Mycobacterium tuberculosis Mycobacterium tuberculosis - drug effects Mycobacterium tuberculosis - genetics Mycobacterium tuberculosis - isolation & purification Polymorphism, Single-Stranded Conformational Promoter Regions, Genetic Promoters rrs gene Sequence Analysis, DNA Single strand conformation polymorphism Tuberculosis Tuberculosis, Multidrug-Resistant - microbiology
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