The effect of thiocolchicoside on cerebral vasospasm following experimental subarachnoid hemorrhage in the rabbit
Background This study investigated the effects of thiocolchicoside to prevent cerebral vasospasm in a rabbit model of subarachnoid hemorrhage. Methods Twenty-four adult male New Zealand white rabbits were randomly divided into three groups of eight rabbits each: group 1 (control), group 2 (subarachn...
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| Veröffentlicht in: | Acta neurochirurgica 2012-08, Vol.154 (8), p.1431-1436 |
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| container_title | Acta neurochirurgica |
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| creator | Kertmen, Hayri Gürer, Bora Yilmaz, Erdal Resit Arikok, Ata Türker Demirci, Adnan Gökyaprak, Salih Metin Sekerci, Zeki |
| description | Background
This study investigated the effects of thiocolchicoside to prevent cerebral vasospasm in a rabbit model of subarachnoid hemorrhage.
Methods
Twenty-four adult male New Zealand white rabbits were randomly divided into three groups of eight rabbits each: group 1 (control), group 2 (subarachnoid hemorrhage), group 3 (treatment). Thiocolchicoside (4 mg/kg, intraperitoneally) was administered just before intracisternal blood injection and continued for 72 h once a day in the same dose for group 3. Animals were killed 72 h after subarachnoid hemorrhage. Basilar artery cross-sectional areas and arterial wall thicknesses were measured in all groups.
Results
Intraperitoneal administration of thiocolchicoside was found to attenuate cerebral vasospasm after subarachnoid hemorrhage in rabbits. Thiocolchicoside treatment was determined to be effective in increasing the luminal area and reducing the wall thickness of the basilar artery.
Conclusions
Our findings, for the first time, showed that TCC can prevent vasospasm induced by SAH. Our results also showed that GABAergic activity may play an important role in cerebral vasospasm etiopathogenesis. In conclusion, the thiocolchicoside treatment might be beneficial in preventing vasospasm after subarachnoid hemorrhage, thus showing potential for clinical application. |
| doi_str_mv | 10.1007/s00701-012-1420-3 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1069199609</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1030348418</sourcerecordid><originalsourceid>FETCH-LOGICAL-c471t-9f12bd2b0da57696a98d4a9dead94e19faa2d95f49bb00f25557c792287b99153</originalsourceid><addsrcrecordid>eNqNkU1LHTEUhoNU6kf7A7qRQDdupiaZzGTOUkTbguDGrod8nNyJzEyuyYy1_77Rq0UKhW5OEs5z3pA8hHzi7AtnTJ3lUhivGBcVl4JV9R45ZCBFVQp7V_asdFvRdgfkKOe7chJK1u_JgRBKiFrBIbm_HZCi92gXGj1dhhBtHO0QbMzBIY0ztZjQJD3SB51j3uo8UR_HMf4M84bi4xZTmHBeCpBXo5O2wxyDowNOMaVBb5CGuQQjTdqYsHwg-16PGT--rMfkx9Xl7cW36vrm6_eL8-vKSsWXCjwXxgnDnG5UC62GzkkNDrUDiRy81sJB4yUYw5gXTdMoq0CIThkA3tTH5HSXu03xfsW89FPIFsdRzxjX3HPWAgdoGfwHWrNadpJ3Bf38F3oX1zSXhzxTnEPd8ELxHWVTzDmh77flk3T6VaD-SV2_U9cXI_2Tur4uMycvyauZ0P2ZeHVVALEDcmnNG0xvr_5X6m_0KqRF</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1030119351</pqid></control><display><type>article</type><title>The effect of thiocolchicoside on cerebral vasospasm following experimental subarachnoid hemorrhage in the rabbit</title><source>MEDLINE</source><source>SpringerNature Journals</source><creator>Kertmen, Hayri ; Gürer, Bora ; Yilmaz, Erdal Resit ; Arikok, Ata Türker ; Demirci, Adnan ; Gökyaprak, Salih Metin ; Sekerci, Zeki</creator><creatorcontrib>Kertmen, Hayri ; Gürer, Bora ; Yilmaz, Erdal Resit ; Arikok, Ata Türker ; Demirci, Adnan ; Gökyaprak, Salih Metin ; Sekerci, Zeki</creatorcontrib><description>Background
This study investigated the effects of thiocolchicoside to prevent cerebral vasospasm in a rabbit model of subarachnoid hemorrhage.
Methods
Twenty-four adult male New Zealand white rabbits were randomly divided into three groups of eight rabbits each: group 1 (control), group 2 (subarachnoid hemorrhage), group 3 (treatment). Thiocolchicoside (4 mg/kg, intraperitoneally) was administered just before intracisternal blood injection and continued for 72 h once a day in the same dose for group 3. Animals were killed 72 h after subarachnoid hemorrhage. Basilar artery cross-sectional areas and arterial wall thicknesses were measured in all groups.
Results
Intraperitoneal administration of thiocolchicoside was found to attenuate cerebral vasospasm after subarachnoid hemorrhage in rabbits. Thiocolchicoside treatment was determined to be effective in increasing the luminal area and reducing the wall thickness of the basilar artery.
Conclusions
Our findings, for the first time, showed that TCC can prevent vasospasm induced by SAH. Our results also showed that GABAergic activity may play an important role in cerebral vasospasm etiopathogenesis. In conclusion, the thiocolchicoside treatment might be beneficial in preventing vasospasm after subarachnoid hemorrhage, thus showing potential for clinical application.</description><identifier>ISSN: 0001-6268</identifier><identifier>EISSN: 0942-0940</identifier><identifier>DOI: 10.1007/s00701-012-1420-3</identifier><identifier>PMID: 22722379</identifier><language>eng</language><publisher>Vienna: Springer Vienna</publisher><subject>Animal models ; Animals ; Arteries ; Basilar Artery - drug effects ; Basilar Artery - pathology ; Blood ; Colchicine - analogs & derivatives ; Colchicine - therapeutic use ; Disease Models, Animal ; Experimental Research ; gamma -Aminobutyric acid ; Interventional Radiology ; Male ; Medicine ; Medicine & Public Health ; Minimally Invasive Surgery ; Muscle, Smooth, Vascular - drug effects ; Muscle, Smooth, Vascular - pathology ; Neurology ; Neuroradiology ; Neurosurgery ; Rabbits ; subarachnoid hemorrhage ; Subarachnoid Hemorrhage - complications ; Subarachnoid Hemorrhage - pathology ; Surgical Orthopedics ; Therapeutic applications ; Vasoconstriction ; Vasospasm, Intracranial - drug therapy ; Vasospasm, Intracranial - etiology</subject><ispartof>Acta neurochirurgica, 2012-08, Vol.154 (8), p.1431-1436</ispartof><rights>Springer-Verlag 2012</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c471t-9f12bd2b0da57696a98d4a9dead94e19faa2d95f49bb00f25557c792287b99153</citedby><cites>FETCH-LOGICAL-c471t-9f12bd2b0da57696a98d4a9dead94e19faa2d95f49bb00f25557c792287b99153</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00701-012-1420-3$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00701-012-1420-3$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22722379$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kertmen, Hayri</creatorcontrib><creatorcontrib>Gürer, Bora</creatorcontrib><creatorcontrib>Yilmaz, Erdal Resit</creatorcontrib><creatorcontrib>Arikok, Ata Türker</creatorcontrib><creatorcontrib>Demirci, Adnan</creatorcontrib><creatorcontrib>Gökyaprak, Salih Metin</creatorcontrib><creatorcontrib>Sekerci, Zeki</creatorcontrib><title>The effect of thiocolchicoside on cerebral vasospasm following experimental subarachnoid hemorrhage in the rabbit</title><title>Acta neurochirurgica</title><addtitle>Acta Neurochir</addtitle><addtitle>Acta Neurochir (Wien)</addtitle><description>Background
This study investigated the effects of thiocolchicoside to prevent cerebral vasospasm in a rabbit model of subarachnoid hemorrhage.
Methods
Twenty-four adult male New Zealand white rabbits were randomly divided into three groups of eight rabbits each: group 1 (control), group 2 (subarachnoid hemorrhage), group 3 (treatment). Thiocolchicoside (4 mg/kg, intraperitoneally) was administered just before intracisternal blood injection and continued for 72 h once a day in the same dose for group 3. Animals were killed 72 h after subarachnoid hemorrhage. Basilar artery cross-sectional areas and arterial wall thicknesses were measured in all groups.
Results
Intraperitoneal administration of thiocolchicoside was found to attenuate cerebral vasospasm after subarachnoid hemorrhage in rabbits. Thiocolchicoside treatment was determined to be effective in increasing the luminal area and reducing the wall thickness of the basilar artery.
Conclusions
Our findings, for the first time, showed that TCC can prevent vasospasm induced by SAH. Our results also showed that GABAergic activity may play an important role in cerebral vasospasm etiopathogenesis. In conclusion, the thiocolchicoside treatment might be beneficial in preventing vasospasm after subarachnoid hemorrhage, thus showing potential for clinical application.</description><subject>Animal models</subject><subject>Animals</subject><subject>Arteries</subject><subject>Basilar Artery - drug effects</subject><subject>Basilar Artery - pathology</subject><subject>Blood</subject><subject>Colchicine - analogs & derivatives</subject><subject>Colchicine - therapeutic use</subject><subject>Disease Models, Animal</subject><subject>Experimental Research</subject><subject>gamma -Aminobutyric acid</subject><subject>Interventional Radiology</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Minimally Invasive Surgery</subject><subject>Muscle, Smooth, Vascular - drug effects</subject><subject>Muscle, Smooth, Vascular - pathology</subject><subject>Neurology</subject><subject>Neuroradiology</subject><subject>Neurosurgery</subject><subject>Rabbits</subject><subject>subarachnoid hemorrhage</subject><subject>Subarachnoid Hemorrhage - complications</subject><subject>Subarachnoid Hemorrhage - pathology</subject><subject>Surgical Orthopedics</subject><subject>Therapeutic applications</subject><subject>Vasoconstriction</subject><subject>Vasospasm, Intracranial - drug therapy</subject><subject>Vasospasm, Intracranial - etiology</subject><issn>0001-6268</issn><issn>0942-0940</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNqNkU1LHTEUhoNU6kf7A7qRQDdupiaZzGTOUkTbguDGrod8nNyJzEyuyYy1_77Rq0UKhW5OEs5z3pA8hHzi7AtnTJ3lUhivGBcVl4JV9R45ZCBFVQp7V_asdFvRdgfkKOe7chJK1u_JgRBKiFrBIbm_HZCi92gXGj1dhhBtHO0QbMzBIY0ztZjQJD3SB51j3uo8UR_HMf4M84bi4xZTmHBeCpBXo5O2wxyDowNOMaVBb5CGuQQjTdqYsHwg-16PGT--rMfkx9Xl7cW36vrm6_eL8-vKSsWXCjwXxgnDnG5UC62GzkkNDrUDiRy81sJB4yUYw5gXTdMoq0CIThkA3tTH5HSXu03xfsW89FPIFsdRzxjX3HPWAgdoGfwHWrNadpJ3Bf38F3oX1zSXhzxTnEPd8ELxHWVTzDmh77flk3T6VaD-SV2_U9cXI_2Tur4uMycvyauZ0P2ZeHVVALEDcmnNG0xvr_5X6m_0KqRF</recordid><startdate>20120801</startdate><enddate>20120801</enddate><creator>Kertmen, Hayri</creator><creator>Gürer, Bora</creator><creator>Yilmaz, Erdal Resit</creator><creator>Arikok, Ata Türker</creator><creator>Demirci, Adnan</creator><creator>Gökyaprak, Salih Metin</creator><creator>Sekerci, Zeki</creator><general>Springer Vienna</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TK</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20120801</creationdate><title>The effect of thiocolchicoside on cerebral vasospasm following experimental subarachnoid hemorrhage in the rabbit</title><author>Kertmen, Hayri ; Gürer, Bora ; Yilmaz, Erdal Resit ; Arikok, Ata Türker ; Demirci, Adnan ; Gökyaprak, Salih Metin ; Sekerci, Zeki</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c471t-9f12bd2b0da57696a98d4a9dead94e19faa2d95f49bb00f25557c792287b99153</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Animal models</topic><topic>Animals</topic><topic>Arteries</topic><topic>Basilar Artery - drug effects</topic><topic>Basilar Artery - pathology</topic><topic>Blood</topic><topic>Colchicine - analogs & derivatives</topic><topic>Colchicine - therapeutic use</topic><topic>Disease Models, Animal</topic><topic>Experimental Research</topic><topic>gamma -Aminobutyric acid</topic><topic>Interventional Radiology</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Minimally Invasive Surgery</topic><topic>Muscle, Smooth, Vascular - drug effects</topic><topic>Muscle, Smooth, Vascular - pathology</topic><topic>Neurology</topic><topic>Neuroradiology</topic><topic>Neurosurgery</topic><topic>Rabbits</topic><topic>subarachnoid hemorrhage</topic><topic>Subarachnoid Hemorrhage - complications</topic><topic>Subarachnoid Hemorrhage - pathology</topic><topic>Surgical Orthopedics</topic><topic>Therapeutic applications</topic><topic>Vasoconstriction</topic><topic>Vasospasm, Intracranial - drug therapy</topic><topic>Vasospasm, Intracranial - etiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kertmen, Hayri</creatorcontrib><creatorcontrib>Gürer, Bora</creatorcontrib><creatorcontrib>Yilmaz, Erdal Resit</creatorcontrib><creatorcontrib>Arikok, Ata Türker</creatorcontrib><creatorcontrib>Demirci, Adnan</creatorcontrib><creatorcontrib>Gökyaprak, Salih Metin</creatorcontrib><creatorcontrib>Sekerci, Zeki</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Acta neurochirurgica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kertmen, Hayri</au><au>Gürer, Bora</au><au>Yilmaz, Erdal Resit</au><au>Arikok, Ata Türker</au><au>Demirci, Adnan</au><au>Gökyaprak, Salih Metin</au><au>Sekerci, Zeki</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The effect of thiocolchicoside on cerebral vasospasm following experimental subarachnoid hemorrhage in the rabbit</atitle><jtitle>Acta neurochirurgica</jtitle><stitle>Acta Neurochir</stitle><addtitle>Acta Neurochir (Wien)</addtitle><date>2012-08-01</date><risdate>2012</risdate><volume>154</volume><issue>8</issue><spage>1431</spage><epage>1436</epage><pages>1431-1436</pages><issn>0001-6268</issn><eissn>0942-0940</eissn><abstract>Background
This study investigated the effects of thiocolchicoside to prevent cerebral vasospasm in a rabbit model of subarachnoid hemorrhage.
Methods
Twenty-four adult male New Zealand white rabbits were randomly divided into three groups of eight rabbits each: group 1 (control), group 2 (subarachnoid hemorrhage), group 3 (treatment). Thiocolchicoside (4 mg/kg, intraperitoneally) was administered just before intracisternal blood injection and continued for 72 h once a day in the same dose for group 3. Animals were killed 72 h after subarachnoid hemorrhage. Basilar artery cross-sectional areas and arterial wall thicknesses were measured in all groups.
Results
Intraperitoneal administration of thiocolchicoside was found to attenuate cerebral vasospasm after subarachnoid hemorrhage in rabbits. Thiocolchicoside treatment was determined to be effective in increasing the luminal area and reducing the wall thickness of the basilar artery.
Conclusions
Our findings, for the first time, showed that TCC can prevent vasospasm induced by SAH. Our results also showed that GABAergic activity may play an important role in cerebral vasospasm etiopathogenesis. In conclusion, the thiocolchicoside treatment might be beneficial in preventing vasospasm after subarachnoid hemorrhage, thus showing potential for clinical application.</abstract><cop>Vienna</cop><pub>Springer Vienna</pub><pmid>22722379</pmid><doi>10.1007/s00701-012-1420-3</doi><tpages>6</tpages></addata></record> |
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| source | MEDLINE; SpringerNature Journals |
| subjects | Animal models Animals Arteries Basilar Artery - drug effects Basilar Artery - pathology Blood Colchicine - analogs & derivatives Colchicine - therapeutic use Disease Models, Animal Experimental Research gamma -Aminobutyric acid Interventional Radiology Male Medicine Medicine & Public Health Minimally Invasive Surgery Muscle, Smooth, Vascular - drug effects Muscle, Smooth, Vascular - pathology Neurology Neuroradiology Neurosurgery Rabbits subarachnoid hemorrhage Subarachnoid Hemorrhage - complications Subarachnoid Hemorrhage - pathology Surgical Orthopedics Therapeutic applications Vasoconstriction Vasospasm, Intracranial - drug therapy Vasospasm, Intracranial - etiology |
| title | The effect of thiocolchicoside on cerebral vasospasm following experimental subarachnoid hemorrhage in the rabbit |
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