Specific transcriptional response of four blockers of estrogen receptors on estradiol-modulated genes in the mouse mammary gland

Novel agents for the endocrine therapy of breast cancer are needed, especially in order to take advantage of the multiple consecutive responses observed in metastatic progressing breast cancer following previous hormone therapy, thus delaying the use of cytotoxic chemotherapy with its frequent poor...

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Veröffentlicht in:	Breast cancer research and treatment 2012-07, Vol.134 (2), p.625-647
Hauptverfasser:	Calvo, Ezequiel, Luu-The, Van, Belleau, Pascal, Martel, Céline, Labrie, Fernand
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Animals Antagonists Antiestrogens Biological and medical sciences Breast cancer Cancer Cancer research Cancer therapies Chemotherapy Cluster Analysis Cytotoxicity Endocrine therapy Estradiol Estradiol - analogs & derivatives Estradiol - pharmacology Estradiol - physiology Estrogen Antagonists - pharmacology Estrogen receptors Estrogens - pharmacology Estrogens - physiology Female Fulvestrant Gene Expression Regulation Genes Genes, Neoplasm Genetic aspects Genetic transcription genomics Gynecology. Andrology. Obstetrics Health aspects Hormones Mammary gland Mammary gland diseases Mammary Glands, Animal - drug effects Mammary Glands, Animal - metabolism Medical sciences Medicine Medicine & Public Health Metastases Mice Mice, Inbred C57BL Oligonucleotide Array Sequence Analysis Oncology Ovariectomy Phenols Piperidines - pharmacology Polymerase chain reaction Preclinical Study Raloxifene Raloxifene Hydrochloride - pharmacology Receptors, Estrogen - antagonists & inhibitors Receptors, Estrogen - metabolism Rodents Side effects Tamoxifen Tamoxifen - pharmacology Transcription Transcription, Genetic - drug effects Transcriptome Tumorigenesis Tumors Uterus
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