Spinal Cord Injury: One-Year Evolution of Motor-Evoked Potentials and Recovery of Leg Motor Function in 255 Patients
Background. The description of the natural course of recovery from a spinal cord injury (SCI) with spontaneous improvement of neurological, neurophysiological, and functional measures is an important prerequisite in appraising effects of upcoming interventional therapies. Objective. To describe the...
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| Veröffentlicht in: | Neurorehabilitation and neural repair 2012-10, Vol.26 (8), p.939-948 |
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| container_title | Neurorehabilitation and neural repair |
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| creator | Petersen, Jens A. Spiess, Martina Curt, Armin Dietz, Volker Schubert, Martin |
| description | Background. The description of the natural course of recovery from a spinal cord injury (SCI) with spontaneous improvement of neurological, neurophysiological, and functional measures is an important prerequisite in appraising effects of upcoming interventional therapies. Objective. To describe the spontaneous evolution of motor-evoked potentials of the anterior tibial muscle (TA-MEP) and their relation to outcomes of lower extremity motor scores (LEMS) and walking function in patients recovering from an acute SCI. Methods. TA-MEPs were assessed in 255 SCI subjects within 5 time intervals throughout the first year after SCI with combined neurological and functional measures. Tibial nerve conduction studies were performed to screen for peripheral nerve damage. Results. TA-MEP allowed stratification of SCI according to lesion severity and outcome. As MEP amplitudes increased over 12 months after SCI, this was paralleled by a significant improvement of LEMS and walking function. TA-MEP latencies remained usually stable. Conclusion. Clinical outcome and walking function after SCI can be predicted independent of clinical measures by assessment of TA-MEP reflecting corticospinal tract integrity. |
| doi_str_mv | 10.1177/1545968312438437 |
| format | Article |
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The description of the natural course of recovery from a spinal cord injury (SCI) with spontaneous improvement of neurological, neurophysiological, and functional measures is an important prerequisite in appraising effects of upcoming interventional therapies. Objective. To describe the spontaneous evolution of motor-evoked potentials of the anterior tibial muscle (TA-MEP) and their relation to outcomes of lower extremity motor scores (LEMS) and walking function in patients recovering from an acute SCI. Methods. TA-MEPs were assessed in 255 SCI subjects within 5 time intervals throughout the first year after SCI with combined neurological and functional measures. Tibial nerve conduction studies were performed to screen for peripheral nerve damage. Results. TA-MEP allowed stratification of SCI according to lesion severity and outcome. As MEP amplitudes increased over 12 months after SCI, this was paralleled by a significant improvement of LEMS and walking function. TA-MEP latencies remained usually stable. Conclusion. Clinical outcome and walking function after SCI can be predicted independent of clinical measures by assessment of TA-MEP reflecting corticospinal tract integrity.</description><identifier>ISSN: 1545-9683</identifier><identifier>EISSN: 1552-6844</identifier><identifier>DOI: 10.1177/1545968312438437</identifier><identifier>PMID: 22460611</identifier><language>eng</language><publisher>Los Angeles, CA: SAGE Publications</publisher><subject>Adult ; Electromyography ; Evoked Potentials, Motor - physiology ; Evolution ; Female ; Humans ; Leg ; Leg - innervation ; Linear Models ; Longitudinal Studies ; Male ; Middle Aged ; Motor evoked potentials ; Muscle, Skeletal - physiopathology ; Muscles ; Nerve conduction ; Neural Conduction - physiology ; Neurology ; Peripheral nerves ; Prospective Studies ; Pyramidal tracts ; Reaction Time - physiology ; Recovery of Function - physiology ; Rehabilitation ; Retrospective Studies ; Spinal Cord Injuries - physiopathology ; Spinal cord injury ; tibial nerve ; Tibial Nerve - physiopathology ; Transcranial Magnetic Stimulation ; Walking ; Walking - physiology</subject><ispartof>Neurorehabilitation and neural repair, 2012-10, Vol.26 (8), p.939-948</ispartof><rights>The Author(s) 2012</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c323t-6bebd0af5601f9c919a35f99505989c509643d57322f6bec04b81ceffc253d1e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.1177/1545968312438437$$EPDF$$P50$$Gsage$$H</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.1177/1545968312438437$$EHTML$$P50$$Gsage$$H</linktohtml><link.rule.ids>314,780,784,21819,27924,27925,43621,43622</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22460611$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Petersen, Jens A.</creatorcontrib><creatorcontrib>Spiess, Martina</creatorcontrib><creatorcontrib>Curt, Armin</creatorcontrib><creatorcontrib>Dietz, Volker</creatorcontrib><creatorcontrib>Schubert, Martin</creatorcontrib><creatorcontrib>EM-SCI Study Group</creatorcontrib><creatorcontrib>EM-SCI Study Group</creatorcontrib><title>Spinal Cord Injury: One-Year Evolution of Motor-Evoked Potentials and Recovery of Leg Motor Function in 255 Patients</title><title>Neurorehabilitation and neural repair</title><addtitle>Neurorehabil Neural Repair</addtitle><description>Background. The description of the natural course of recovery from a spinal cord injury (SCI) with spontaneous improvement of neurological, neurophysiological, and functional measures is an important prerequisite in appraising effects of upcoming interventional therapies. Objective. To describe the spontaneous evolution of motor-evoked potentials of the anterior tibial muscle (TA-MEP) and their relation to outcomes of lower extremity motor scores (LEMS) and walking function in patients recovering from an acute SCI. Methods. TA-MEPs were assessed in 255 SCI subjects within 5 time intervals throughout the first year after SCI with combined neurological and functional measures. Tibial nerve conduction studies were performed to screen for peripheral nerve damage. Results. TA-MEP allowed stratification of SCI according to lesion severity and outcome. As MEP amplitudes increased over 12 months after SCI, this was paralleled by a significant improvement of LEMS and walking function. TA-MEP latencies remained usually stable. Conclusion. Clinical outcome and walking function after SCI can be predicted independent of clinical measures by assessment of TA-MEP reflecting corticospinal tract integrity.</description><subject>Adult</subject><subject>Electromyography</subject><subject>Evoked Potentials, Motor - physiology</subject><subject>Evolution</subject><subject>Female</subject><subject>Humans</subject><subject>Leg</subject><subject>Leg - innervation</subject><subject>Linear Models</subject><subject>Longitudinal Studies</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Motor evoked potentials</subject><subject>Muscle, Skeletal - physiopathology</subject><subject>Muscles</subject><subject>Nerve conduction</subject><subject>Neural Conduction - physiology</subject><subject>Neurology</subject><subject>Peripheral nerves</subject><subject>Prospective Studies</subject><subject>Pyramidal tracts</subject><subject>Reaction Time - physiology</subject><subject>Recovery of Function - physiology</subject><subject>Rehabilitation</subject><subject>Retrospective Studies</subject><subject>Spinal Cord Injuries - physiopathology</subject><subject>Spinal cord injury</subject><subject>tibial nerve</subject><subject>Tibial Nerve - physiopathology</subject><subject>Transcranial Magnetic Stimulation</subject><subject>Walking</subject><subject>Walking - physiology</subject><issn>1545-9683</issn><issn>1552-6844</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkE1LAzEQhoMotlYvnjxJj15WZ5JMdnOU4keh4EE9L9lsIrtsuzXpHvrvTWn1IAjCwAzM8z6Hl7ErhFvEPL9DkqRVIZBLUUiRH7ExEvFMFVIe725J2e4_YmcxtgBcFBpO2YhzqUAhjtnl67pZmW4660M9na_aIWzP2Yk3XXQXhz1h748Pb7PnbPHyNJ_dLzIruNhkqnJVDcaTAvTaatRGkNeagHShLYFWUtSUC859Yi3IqkDrvLecRI1OTNjN3rsO_efg4qZcNtG6rjMr1w-xRFBJmiPxf6BCp9EgEwp71IY-xuB8uQ7N0oRtgspdaeXv0lLk-mAfqqWrfwLfLSUg2wPRfLiy7YeQKot_C78AOIlwSQ</recordid><startdate>201210</startdate><enddate>201210</enddate><creator>Petersen, Jens A.</creator><creator>Spiess, Martina</creator><creator>Curt, Armin</creator><creator>Dietz, Volker</creator><creator>Schubert, Martin</creator><general>SAGE Publications</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7TK</scope></search><sort><creationdate>201210</creationdate><title>Spinal Cord Injury</title><author>Petersen, Jens A. ; Spiess, Martina ; Curt, Armin ; Dietz, Volker ; Schubert, Martin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c323t-6bebd0af5601f9c919a35f99505989c509643d57322f6bec04b81ceffc253d1e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Adult</topic><topic>Electromyography</topic><topic>Evoked Potentials, Motor - physiology</topic><topic>Evolution</topic><topic>Female</topic><topic>Humans</topic><topic>Leg</topic><topic>Leg - innervation</topic><topic>Linear Models</topic><topic>Longitudinal Studies</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Motor evoked potentials</topic><topic>Muscle, Skeletal - physiopathology</topic><topic>Muscles</topic><topic>Nerve conduction</topic><topic>Neural Conduction - physiology</topic><topic>Neurology</topic><topic>Peripheral nerves</topic><topic>Prospective Studies</topic><topic>Pyramidal tracts</topic><topic>Reaction Time - physiology</topic><topic>Recovery of Function - physiology</topic><topic>Rehabilitation</topic><topic>Retrospective Studies</topic><topic>Spinal Cord Injuries - physiopathology</topic><topic>Spinal cord injury</topic><topic>tibial nerve</topic><topic>Tibial Nerve - physiopathology</topic><topic>Transcranial Magnetic Stimulation</topic><topic>Walking</topic><topic>Walking - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Petersen, Jens A.</creatorcontrib><creatorcontrib>Spiess, Martina</creatorcontrib><creatorcontrib>Curt, Armin</creatorcontrib><creatorcontrib>Dietz, Volker</creatorcontrib><creatorcontrib>Schubert, Martin</creatorcontrib><creatorcontrib>EM-SCI Study Group</creatorcontrib><creatorcontrib>EM-SCI Study Group</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Neurosciences Abstracts</collection><jtitle>Neurorehabilitation and neural repair</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Petersen, Jens A.</au><au>Spiess, Martina</au><au>Curt, Armin</au><au>Dietz, Volker</au><au>Schubert, Martin</au><aucorp>EM-SCI Study Group</aucorp><aucorp>EM-SCI Study Group</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Spinal Cord Injury: One-Year Evolution of Motor-Evoked Potentials and Recovery of Leg Motor Function in 255 Patients</atitle><jtitle>Neurorehabilitation and neural repair</jtitle><addtitle>Neurorehabil Neural Repair</addtitle><date>2012-10</date><risdate>2012</risdate><volume>26</volume><issue>8</issue><spage>939</spage><epage>948</epage><pages>939-948</pages><issn>1545-9683</issn><eissn>1552-6844</eissn><abstract>Background. The description of the natural course of recovery from a spinal cord injury (SCI) with spontaneous improvement of neurological, neurophysiological, and functional measures is an important prerequisite in appraising effects of upcoming interventional therapies. Objective. To describe the spontaneous evolution of motor-evoked potentials of the anterior tibial muscle (TA-MEP) and their relation to outcomes of lower extremity motor scores (LEMS) and walking function in patients recovering from an acute SCI. Methods. TA-MEPs were assessed in 255 SCI subjects within 5 time intervals throughout the first year after SCI with combined neurological and functional measures. Tibial nerve conduction studies were performed to screen for peripheral nerve damage. Results. TA-MEP allowed stratification of SCI according to lesion severity and outcome. As MEP amplitudes increased over 12 months after SCI, this was paralleled by a significant improvement of LEMS and walking function. TA-MEP latencies remained usually stable. Conclusion. Clinical outcome and walking function after SCI can be predicted independent of clinical measures by assessment of TA-MEP reflecting corticospinal tract integrity.</abstract><cop>Los Angeles, CA</cop><pub>SAGE Publications</pub><pmid>22460611</pmid><doi>10.1177/1545968312438437</doi><tpages>10</tpages></addata></record> |
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| subjects | Adult Electromyography Evoked Potentials, Motor - physiology Evolution Female Humans Leg Leg - innervation Linear Models Longitudinal Studies Male Middle Aged Motor evoked potentials Muscle, Skeletal - physiopathology Muscles Nerve conduction Neural Conduction - physiology Neurology Peripheral nerves Prospective Studies Pyramidal tracts Reaction Time - physiology Recovery of Function - physiology Rehabilitation Retrospective Studies Spinal Cord Injuries - physiopathology Spinal cord injury tibial nerve Tibial Nerve - physiopathology Transcranial Magnetic Stimulation Walking Walking - physiology |
| title | Spinal Cord Injury: One-Year Evolution of Motor-Evoked Potentials and Recovery of Leg Motor Function in 255 Patients |
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