Genotypes of Candida albicans Involved in Development of Candidiasis and Their Distribution in Oral Cavity of Non-Candidiasis Individuals

Genotype characteristics and distribution of commensal Candida albicans should be studied to predict the development of candidiasis, however, extensive genotype analysis of commensal C. albicans has not been made. In this study, 508 C. albicans isolates were collected from patients with/without cand...

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Veröffentlicht in:Medical mycology journal 2011-01, Vol.52 (4), p.315-324
Hauptverfasser: Takagi, Yuki, Hattori, Hisao, Adachi, Hidesada, Takakura, Shunji, Horii, Toshinobu, Chindamporn, Ariya, Kitai, Hiroki, Tanaka, Reiko, Yaguchi, Takashi, Fukano, Hideo, Kawamoto, Fumihiko, Shimozato, Kazuo, Kanbe, Toshio
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container_issue 4
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container_title Medical mycology journal
container_volume 52
creator Takagi, Yuki
Hattori, Hisao
Adachi, Hidesada
Takakura, Shunji
Horii, Toshinobu
Chindamporn, Ariya
Kitai, Hiroki
Tanaka, Reiko
Yaguchi, Takashi
Fukano, Hideo
Kawamoto, Fumihiko
Shimozato, Kazuo
Kanbe, Toshio
description Genotype characteristics and distribution of commensal Candida albicans should be studied to predict the development of candidiasis, however, extensive genotype analysis of commensal C. albicans has not been made. In this study, 508 C. albicans isolates were collected from patients with/without candidiasis and divided into 4 isolate groups (SG-1, oral cavity of non-candidiasis patients; SG-2, patients with cutaneous candidiasis; SG-3, patients with vaginal candidiasis; SG-4, patients with candidemia). These isolates were characterized to study the relationship between genotypes and pathogenicity using microsatellite analysis. Using CDC3 and CAI, 5 genotypes (I, 111: 115/33: 41; II, 115: 119/23: 23; III, 115: 123/18: 27; IV, 115: 123/33: 40; and V, 123: 127/32: 41) were found in 4.2%, 8.9%, 7.1%, 2.2% and 3.1% of the isolates, respectively. Genotypes II and III were commonly found in all isolate groups. These genotypes were further divided into 28 types by additional HIS3 and CAIII microsatellite markers. In this analysis, C. albicans with type 6 and type 23 was widely distributed as a commensal species in the oral cavity of non-candidiasis patients and found to be related with candidiasis development. Additionally, genotypes I and IV were found in SG-2 and/or SG-4, suggesting that the fungus with those genotypes is also involved in this development. In contrast, genotype V was not identified in any infective isolates.
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source J-STAGE (Japan Science & Technology Information Aggregator, Electronic) Freely Available Titles - Japanese; EZB-FREE-00999 freely available EZB journals
subjects Candida albicans
Candidemia
Candidiasis
Commensals
Development
Genetic markers
Genotypes
Microsatellites
Oral cavity
Pathogenicity
Vagina
title Genotypes of Candida albicans Involved in Development of Candidiasis and Their Distribution in Oral Cavity of Non-Candidiasis Individuals
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