Severe cochlear inflammation and vestibular syndrome in an experimental model of Streptococcus suis infection in mice

Hearing impairment is a common and frequently permanent sequel of Streptococcus suis meningitis in humans. Nevertheless, mechanisms underlying the development of cochlear damage have not been addressed so far. In the present work, we characterized a mouse model of suppurative labyrinthitis and menin...

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Veröffentlicht in:	European journal of clinical microbiology & infectious diseases 2012-09, Vol.31 (9), p.2391-2400
Hauptverfasser:	Domínguez-Punaro, M. C., Koedel, U., Hoegen, T., Demel, C., Klein, M., Gottschalk, M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal models Animals Bacteremia Bacteremia - microbiology Bacteremia - pathology Bacteria Biological and medical sciences Biomedical and Life Sciences Biomedicine Blood - microbiology Blood-brain barrier Cochlea Complications Disease Models, Animal Disseminated infection Drug development Endocarditis Female Hearing Hearing loss Hogs Infections Infectious diseases Inflammation Internal Medicine Laboratory animals Labyrinthitis - complications Labyrinthitis - microbiology Labyrinthitis - pathology Medical Microbiology Medical sciences Membrane permeability Meningitis Meningitis, Bacterial - complications Meningitis, Bacterial - microbiology Meningitis, Bacterial - pathology Mice Nervous system (semeiology, syndromes) Nervous system as a whole Neurology Otitis interna Pathogens Sepsis Streptococcal Infections - complications Streptococcal Infections - microbiology Streptococcal Infections - pathology Streptococcus suis Streptococcus suis - pathogenicity Time Factors Tumor necrosis factor-TNF Vestibular Diseases - complications Vestibular Diseases - microbiology Vestibular Diseases - pathology Vestibular system Virulence
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