Severe cochlear inflammation and vestibular syndrome in an experimental model of Streptococcus suis infection in mice
Hearing impairment is a common and frequently permanent sequel of Streptococcus suis meningitis in humans. Nevertheless, mechanisms underlying the development of cochlear damage have not been addressed so far. In the present work, we characterized a mouse model of suppurative labyrinthitis and menin...
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| Veröffentlicht in: | European journal of clinical microbiology & infectious diseases 2012-09, Vol.31 (9), p.2391-2400 |
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| container_title | European journal of clinical microbiology & infectious diseases |
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| creator | Domínguez-Punaro, M. C. Koedel, U. Hoegen, T. Demel, C. Klein, M. Gottschalk, M. |
| description | Hearing impairment is a common and frequently permanent sequel of
Streptococcus suis
meningitis in humans. Nevertheless, mechanisms underlying the development of cochlear damage have not been addressed so far. In the present work, we characterized a mouse model of suppurative labyrinthitis and meningitis induced by a systemic infection with
S. suis
and studied the impact of the injected bacterial dosage on the progression of such inflammatory events. We observed that high infection doses of bacteria lead to sustained bacteremia, with an increase in the permeability of the blood–labyrinth and blood–brain barriers, causing suppurative labyrinthitis and meningitis, respectively. However, in mice infected with a low dose of
S. suis
, bacteria disappeared quickly from blood, hence, cochlear inflammation and meningitis were not consistent features. This model of
S. suis
infection seems ideal to evaluate novel drugs that may help alleviate the negative consequences of such important sequelae of
S. suis
-induced meningitis and labyrinthitis. |
| doi_str_mv | 10.1007/s10096-012-1581-2 |
| format | Article |
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Streptococcus suis
meningitis in humans. Nevertheless, mechanisms underlying the development of cochlear damage have not been addressed so far. In the present work, we characterized a mouse model of suppurative labyrinthitis and meningitis induced by a systemic infection with
S. suis
and studied the impact of the injected bacterial dosage on the progression of such inflammatory events. We observed that high infection doses of bacteria lead to sustained bacteremia, with an increase in the permeability of the blood–labyrinth and blood–brain barriers, causing suppurative labyrinthitis and meningitis, respectively. However, in mice infected with a low dose of
S. suis
, bacteria disappeared quickly from blood, hence, cochlear inflammation and meningitis were not consistent features. This model of
S. suis
infection seems ideal to evaluate novel drugs that may help alleviate the negative consequences of such important sequelae of
S. suis
-induced meningitis and labyrinthitis.</description><identifier>ISSN: 0934-9723</identifier><identifier>EISSN: 1435-4373</identifier><identifier>DOI: 10.1007/s10096-012-1581-2</identifier><identifier>PMID: 22382820</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer-Verlag</publisher><subject>Animal models ; Animals ; Bacteremia ; Bacteremia - microbiology ; Bacteremia - pathology ; Bacteria ; Biological and medical sciences ; Biomedical and Life Sciences ; Biomedicine ; Blood - microbiology ; Blood-brain barrier ; Cochlea ; Complications ; Disease Models, Animal ; Disseminated infection ; Drug development ; Endocarditis ; Female ; Hearing ; Hearing loss ; Hogs ; Infections ; Infectious diseases ; Inflammation ; Internal Medicine ; Laboratory animals ; Labyrinthitis - complications ; Labyrinthitis - microbiology ; Labyrinthitis - pathology ; Medical Microbiology ; Medical sciences ; Membrane permeability ; Meningitis ; Meningitis, Bacterial - complications ; Meningitis, Bacterial - microbiology ; Meningitis, Bacterial - pathology ; Mice ; Nervous system (semeiology, syndromes) ; Nervous system as a whole ; Neurology ; Otitis interna ; Pathogens ; Sepsis ; Streptococcal Infections - complications ; Streptococcal Infections - microbiology ; Streptococcal Infections - pathology ; Streptococcus suis ; Streptococcus suis - pathogenicity ; Time Factors ; Tumor necrosis factor-TNF ; Vestibular Diseases - complications ; Vestibular Diseases - microbiology ; Vestibular Diseases - pathology ; Vestibular system ; Virulence</subject><ispartof>European journal of clinical microbiology & infectious diseases, 2012-09, Vol.31 (9), p.2391-2400</ispartof><rights>Springer-Verlag 2012</rights><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c435t-1ae52deadca56038a99209e79d41c304c5ab97c3b30ac439a1aef98b7f551db23</citedby><cites>FETCH-LOGICAL-c435t-1ae52deadca56038a99209e79d41c304c5ab97c3b30ac439a1aef98b7f551db23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10096-012-1581-2$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10096-012-1581-2$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,777,781,27905,27906,41469,42538,51300</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=26255106$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22382820$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Domínguez-Punaro, M. C.</creatorcontrib><creatorcontrib>Koedel, U.</creatorcontrib><creatorcontrib>Hoegen, T.</creatorcontrib><creatorcontrib>Demel, C.</creatorcontrib><creatorcontrib>Klein, M.</creatorcontrib><creatorcontrib>Gottschalk, M.</creatorcontrib><title>Severe cochlear inflammation and vestibular syndrome in an experimental model of Streptococcus suis infection in mice</title><title>European journal of clinical microbiology & infectious diseases</title><addtitle>Eur J Clin Microbiol Infect Dis</addtitle><addtitle>Eur J Clin Microbiol Infect Dis</addtitle><description>Hearing impairment is a common and frequently permanent sequel of
Streptococcus suis
meningitis in humans. Nevertheless, mechanisms underlying the development of cochlear damage have not been addressed so far. In the present work, we characterized a mouse model of suppurative labyrinthitis and meningitis induced by a systemic infection with
S. suis
and studied the impact of the injected bacterial dosage on the progression of such inflammatory events. We observed that high infection doses of bacteria lead to sustained bacteremia, with an increase in the permeability of the blood–labyrinth and blood–brain barriers, causing suppurative labyrinthitis and meningitis, respectively. However, in mice infected with a low dose of
S. suis
, bacteria disappeared quickly from blood, hence, cochlear inflammation and meningitis were not consistent features. This model of
S. suis
infection seems ideal to evaluate novel drugs that may help alleviate the negative consequences of such important sequelae of
S. suis
-induced meningitis and labyrinthitis.</description><subject>Animal models</subject><subject>Animals</subject><subject>Bacteremia</subject><subject>Bacteremia - microbiology</subject><subject>Bacteremia - pathology</subject><subject>Bacteria</subject><subject>Biological and medical sciences</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Blood - microbiology</subject><subject>Blood-brain barrier</subject><subject>Cochlea</subject><subject>Complications</subject><subject>Disease Models, Animal</subject><subject>Disseminated infection</subject><subject>Drug development</subject><subject>Endocarditis</subject><subject>Female</subject><subject>Hearing</subject><subject>Hearing loss</subject><subject>Hogs</subject><subject>Infections</subject><subject>Infectious diseases</subject><subject>Inflammation</subject><subject>Internal Medicine</subject><subject>Laboratory animals</subject><subject>Labyrinthitis - complications</subject><subject>Labyrinthitis - microbiology</subject><subject>Labyrinthitis - pathology</subject><subject>Medical Microbiology</subject><subject>Medical sciences</subject><subject>Membrane permeability</subject><subject>Meningitis</subject><subject>Meningitis, Bacterial - complications</subject><subject>Meningitis, Bacterial - microbiology</subject><subject>Meningitis, Bacterial - pathology</subject><subject>Mice</subject><subject>Nervous system (semeiology, syndromes)</subject><subject>Nervous system as a whole</subject><subject>Neurology</subject><subject>Otitis interna</subject><subject>Pathogens</subject><subject>Sepsis</subject><subject>Streptococcal Infections - complications</subject><subject>Streptococcal Infections - microbiology</subject><subject>Streptococcal Infections - pathology</subject><subject>Streptococcus suis</subject><subject>Streptococcus suis - pathogenicity</subject><subject>Time Factors</subject><subject>Tumor necrosis factor-TNF</subject><subject>Vestibular Diseases - complications</subject><subject>Vestibular Diseases - microbiology</subject><subject>Vestibular Diseases - pathology</subject><subject>Vestibular system</subject><subject>Virulence</subject><issn>0934-9723</issn><issn>1435-4373</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqFkUtv1TAQhS1ERS-FH8AGWUJIbFL8iON4iSpeUqUuCuto4kwglWNf7KSi_54J9_IQEurGXsx3juf4MPZMinMphH1d6HRNJaSqpGllpR6wnay1qWpt9UO2E07XlbNKn7LHpdwI0rTWPmKnSulWtUrs2HqNt5iR--S_BoTMpzgGmGdYphQ5xIHfYlmmfg00K3dxyGlGgmjE8fse8zRjXCDwOQ0YeBr59ZJxvyQy9GvhZZ3K5on-pyEJ58njE3YyQij49Hifsc_v3n66-FBdXr3_ePHmsvKUYqkkoFEDwuDBNEK34JwSDq0baum1qL2B3lmvey2AFA5IMLq2t6MxcuiVPmOvDr77nL6tFKSbp-IxBIiY1tJJ0TjpjKVPux_V2ui6aTWhL_5Bb9KaIwXZKKuskK0kSh4on1MpGcduT58F-Y6gbquvO9TXUX3dVl-37fv86Lz2Mw6_Fb_6IuDlEYDiIYwZop_KH65RlFw0xKkDV2gUv2D-e8X_vf4DtJGy9g</recordid><startdate>20120901</startdate><enddate>20120901</enddate><creator>Domínguez-Punaro, M. 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C.</au><au>Koedel, U.</au><au>Hoegen, T.</au><au>Demel, C.</au><au>Klein, M.</au><au>Gottschalk, M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Severe cochlear inflammation and vestibular syndrome in an experimental model of Streptococcus suis infection in mice</atitle><jtitle>European journal of clinical microbiology & infectious diseases</jtitle><stitle>Eur J Clin Microbiol Infect Dis</stitle><addtitle>Eur J Clin Microbiol Infect Dis</addtitle><date>2012-09-01</date><risdate>2012</risdate><volume>31</volume><issue>9</issue><spage>2391</spage><epage>2400</epage><pages>2391-2400</pages><issn>0934-9723</issn><eissn>1435-4373</eissn><abstract>Hearing impairment is a common and frequently permanent sequel of
Streptococcus suis
meningitis in humans. Nevertheless, mechanisms underlying the development of cochlear damage have not been addressed so far. In the present work, we characterized a mouse model of suppurative labyrinthitis and meningitis induced by a systemic infection with
S. suis
and studied the impact of the injected bacterial dosage on the progression of such inflammatory events. We observed that high infection doses of bacteria lead to sustained bacteremia, with an increase in the permeability of the blood–labyrinth and blood–brain barriers, causing suppurative labyrinthitis and meningitis, respectively. However, in mice infected with a low dose of
S. suis
, bacteria disappeared quickly from blood, hence, cochlear inflammation and meningitis were not consistent features. This model of
S. suis
infection seems ideal to evaluate novel drugs that may help alleviate the negative consequences of such important sequelae of
S. suis
-induced meningitis and labyrinthitis.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer-Verlag</pub><pmid>22382820</pmid><doi>10.1007/s10096-012-1581-2</doi><tpages>10</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0934-9723 |
| ispartof | European journal of clinical microbiology & infectious diseases, 2012-09, Vol.31 (9), p.2391-2400 |
| issn | 0934-9723 1435-4373 |
| language | eng |
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| subjects | Animal models Animals Bacteremia Bacteremia - microbiology Bacteremia - pathology Bacteria Biological and medical sciences Biomedical and Life Sciences Biomedicine Blood - microbiology Blood-brain barrier Cochlea Complications Disease Models, Animal Disseminated infection Drug development Endocarditis Female Hearing Hearing loss Hogs Infections Infectious diseases Inflammation Internal Medicine Laboratory animals Labyrinthitis - complications Labyrinthitis - microbiology Labyrinthitis - pathology Medical Microbiology Medical sciences Membrane permeability Meningitis Meningitis, Bacterial - complications Meningitis, Bacterial - microbiology Meningitis, Bacterial - pathology Mice Nervous system (semeiology, syndromes) Nervous system as a whole Neurology Otitis interna Pathogens Sepsis Streptococcal Infections - complications Streptococcal Infections - microbiology Streptococcal Infections - pathology Streptococcus suis Streptococcus suis - pathogenicity Time Factors Tumor necrosis factor-TNF Vestibular Diseases - complications Vestibular Diseases - microbiology Vestibular Diseases - pathology Vestibular system Virulence |
| title | Severe cochlear inflammation and vestibular syndrome in an experimental model of Streptococcus suis infection in mice |
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