Increase of 20-HETE synthase after brain ischemia in rats revealed by PET study with super(11)C-labeled 20-HETE synthase-specific inhibitor

20-Hydroxyeicosatetraenoic acid (20-HETE), an arachidonic acid metabolite known to be produced after cerebral ischemia, has been implicated in ischemic and reperfusion injury by mediating vasoconstriction. To develop a positron emission tomography (PET) probe for 20-HETE synthase imaging, which migh...

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Veröffentlicht in:	Journal of cerebral blood flow and metabolism 2012-09, Vol.32 (9), p.1737-1746
Hauptverfasser:	Kawasaki, Toshiyuki, Marumo, Toshiyuki, Shirakami, Keiko, Mori, Tomoko, Doi, Hisashi, Suzuki, Masaaki, Watanabe, Yasuyoshi, Chaki, Shigeyuki, Nakazato, Atsuro, Ago, Yukio, Hashimoto, Hitoshi, Matsuda, Toshio, Baba, Akemichi, Onoe, Hirotaka
Format:	Artikel
Sprache:	eng
Schlagworte:	Arachidonic acid Brain Cerebral blood flow imidazole Injuries Ischemia Kidney Liver Metabolites Neuroimaging Polymerase chain reaction Positron emission tomography Probes Reperfusion Vasoconstriction
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